Interleukin 10: the critical role of a pleiotropic cytokine in food allergy

Nedelkopoulou, Natalia; Dhawan, Anil; Xinias, Ioannis; Gidaris, Dimos; Farmaki, Evangelia

doi:10.1016/j.aller.2019.10.003

Cited by 14 publications

(5 citation statements)

References 75 publications

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“…Related studies have shown that significant IL-6 immune reactivity is found in tonsil tissues around actinomycetes colonies [32]. IL-10, as a key immunomodulatory cytokine, may affect T cell and dendritic cell (DC) production, and regulate DC function by reducing the secretion of surface markers and inflammatory cytokines [33].…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis for alterations of intestinal flora in hepatocellular carcinoma patients: combinatorial detection of Coriobacterium, Atopobium, Coprococcus and Veillonella dispar may be a new method for HCC diagnosis

Jiang

Tao³

et al. 2023

Journal of Medical Microbiology

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Introduction. Hepatocellular carcinoma (HCC) is one of the most common malignant tumours in the world. Due to the characteristics of low early diagnosis rate, high malignancy and rapid progression, the majority of diagnosed patients are in the middle or late stage. Accumulating evidence reveals that intestinal flora imbalance will aggravate HCC by disturbing immune regulation, especially interleukin expression. Therefore, intestinal flora-based methods have the potential to be new diagnostic or therapeutic methods for HCC. Hypothesis. Compositions of intestinal florae were different between HCC patients and healthy people. Further, intestinal florae may alleviate or aggravate HCCs. Methods. To determine which intestinal florae and interleukin aggravate HCCs, we studied the differences in intestinal florae composition and interleukin (IL) indices between HCC patients and healthy people. A total of 64 HCC patients and 24 healthy people were recruited, and their fresh stool samples and serum samples were collected for 16S rRNA sequencing and metabolite index measurement. Results. Data showed that 484 operational taxonomic units (OTUs) and 476 OTUs were detected in the HCC and control groups, respectively. From the phylum level to the species level, 5, 6, 10, 15, 23 and 19 colonies showed differential abundance between the HCC group and healthy people. Moreover, interleukin-6 expression and interleukin-10 expression were significantly different between two groups. Of note, differences of Coriobacterium , Atopobium and Coprococcus at genus level and Veillonella dispar at species level in two groups were significantly related to IL-6 and IL-10. Conclusion. The abundance of intestinal florae in the HCC group was different from the control group. Additionally, combinatorial detection of Coriobacterium , Atopobium and Coprococcus at genus level and V. dispar at species level may be a new method for HCC diagnosis.

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Section: Discussionmentioning

confidence: 99%

Correlation analysis for alterations of intestinal flora in hepatocellular carcinoma patients: combinatorial detection of Coriobacterium, Atopobium, Coprococcus and Veillonella dispar may be a new method for HCC diagnosis

Jiang

Tao³

et al. 2023

Journal of Medical Microbiology

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“…One important aspect is the development of allergen-specific CD4 + CD25 + T-reg-cells secreting IL-10 in the AIT of FA diseases. Moreover, butyrate influences intestinal CD103 + DC by stimulating the GPR109a cell surface receptor, which enables this tolerogenic DC subpopulation to induce proliferation and expansion of Treg cells in MLN [82,[86][87][88]. This expansion of intestinal Treg cells is owing to butyrate promoting the acetylation of histones at the FOXP3 gene inhibiting lysine deacetylase, protecting at the same time the FOXP3 protein from degradation through enhancing its acetylation, and this suppresses inflammation and untoward immune responses in intestinal tissues [89].…”

Section: Butyratementioning

confidence: 99%

Epigenetics in Food Allergy and Immunomodulation

et al. 2021

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Food allergy (FA) is an increasing problem worldwide and, over recent years, its prevalence is rising in developed countries. Nowadays, the immunological and cellular processes that occur in the allergic reactions are not fully understood, which hampers the development of in vitro diagnostic tools and further treatment options. Moreover, allergic diseases could be reinforced by environmental exposure and genetic modifications. Gene expression can be controlled by different epigenetic mechanisms like DNA methylation, histone modifications, and microRNAs. In addition, several environmental factors such as dietary components (vitamin D, butyrate, folic acid) are able to regulate this epigenetic mechanism. All these factors produce modifications in immune genes that could alter the development and function of immune cells, and therefore the etiology of the disease. Furthermore, these epigenetic mechanisms have also an influence on immunomodulation, which could explain sustained responsiveness or unresponsiveness during immunotherapy due to epigenetic modifications in key genes that induce tolerance in several FA. Thus, in this review we focus on the different epigenetic mechanisms that occur in FA and on the influence of several dietary components in these gene modifications.

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“…Tr1 cells can be induced by DC-derived IL -10 [8]. Dysfunctional Tr1 cells have been noted in individuals with FA [9,10]. Factors and mechanisms that affect the functional status of Tr1 cells are not fully understood yet.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway

Zeng,

Xu,

Liu

et al. 2024

Preprint

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The pathogenesis of food allergy (FA) is still not fully understood. Telomerases are involved in the regulation of immune responses. The aim of this study is to understand the contribution of telomerase reverse transcriptase (TERT) to the pathogenesis of FA. A murine FA model was established with ovalbumin as the specific antigen. This murine model was used to test the role of TERT in the regulation of dendritic cell (DC) immune tolerogenic functions. We observed that the Tert promoter was at demethylation status and the Tert expression was elevated in DCs of FA mice. The FA response was positively correlated with the Tert expression in DCs. Induction of Il10 expression in DCs was hindered by TERT. TERT hindered the immune tolerogenic functions of DCs. The immune tolerogenic functions of DC were restored by CpG by boosting the Tert promoter methylation. Administration of CpG promoted the therapeutic effects of allergen specific immunotherapy in FA mice. In conclusion, low levels of Il10 expression and high levels of Tert expression were observed in intestinal DCs of FA mice. CpG exposure restored the expression of Il10 and increased the therapeutic benefits of allergen-specific immunotherapy.

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Interleukin 10: the critical role of a pleiotropic cytokine in food allergy

Cited by 14 publications

References 75 publications

Correlation analysis for alterations of intestinal flora in hepatocellular carcinoma patients: combinatorial detection of Coriobacterium, Atopobium, Coprococcus and Veillonella dispar may be a new method for HCC diagnosis

Correlation analysis for alterations of intestinal flora in hepatocellular carcinoma patients: combinatorial detection of Coriobacterium, Atopobium, Coprococcus and Veillonella dispar may be a new method for HCC diagnosis

Epigenetics in Food Allergy and Immunomodulation

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway

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