Interleukin-10 rs1800871 (−819C/T) and ATA haplotype are associated with preeclampsia in a Tunisian population

Raguema, Nozha; Gannoun, Marwa Ben Ali; Zitouni, Hédia; Meddeb, S.; Benletaifa, Dhafer; Lavoie, Julie L.; Almawi, Wassim Y.; Mahjoub, Touhami

doi:10.1016/j.preghy.2018.01.011

Cited by 14 publications

(13 citation statements)

References 44 publications

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“…[ 28 ] Moreover, it was reported that IL-10 -819C/T are associated with PE in different populations. [ 25 , 29 ] On the contrary, some studies have demonstrated that there was no correlation between IL-10 -819C/T and -592A/C polymorphisms and PE risk. [ 22 ] Due to the limitation of sample size and the genetic characteristics of different ethnicity, the conclusion is contradictory.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Che

Liu

et al. 2021

Medicine

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Objective: The purpose of our study was to investigate whether IL-10 -819C/T, -592A/C polymorphisms were associated with preeclampsia (PE) susceptibility.Methods: A comprehensive and systematic literature search was performed through online databases, including Web of Science, PubMed, EMBASE, and Chinese databases. Then eligible literatures were included according to inclusion criteria and exclusion criteria. Statistical data analysis was performed using Stata 10.0 software. Odds ratios (OR) and 95% confidence interval were applied to evaluated the association between IL-10 -819C/T, -592A/C polymorphisms and PE susceptibility.Results: According to inclusion and exclusion criteria, 9 case-control studies, including 1423 cases and 2031 controls, were included in this meta-analysis. Our meta-analysis revealed that no association was found between IL-10 -819C/T, -592A/C polymorphisms and the risk of PE in our study. Conclusion:Our meta-analysis suggested that IL-10 -819C/T and -592A/C polymorphisms had no association with PE susceptibility, but had a significant association with PE susceptibility in Asian and Caucasian.

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Section: Discussionmentioning

confidence: 99%

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Che

Liu

et al. 2021

Medicine

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“…Consistent with others' findings, we confirmed that MLB functions as an inhibitor against inflammation in both the serum and placenta of PIH rats ( Figure 2 ). All the inflammatory markers were significantly increased in PIH, indicating that women who developed PIH later had an inflammatory milieu from the beginning of pregnancy [ 26 ]. Inhibition of inflammatory response has been suggested to relieve PIH [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Magnesium Lithospermate B Downregulates the Levels of Blood Pressure, Inflammation, and Oxidative Stress in Pregnant Rats with Hypertension

Zang

Peng³

et al. 2020

International Journal of Hypertension

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Background. Magnesium lithospermate B (MLB) was shown to suppress oxidative stress and reduce hypertension, but the role of MLB in pregnancy-induced hypertension (PIH) remains unknown. The objective of this study was to demonstrate the effects of MLB on rats with PIH. Methods. A total of 40 pregnant SD rats were selected, and 30 rats were orally given NG-nitro-L-arginine methyl ester (L-NAME, 60 mg/kg/day) to establish PIH rat models. Rats were equally divided into four groups: control, PIH, 5 mg/kg MLB, and 10 mg/kg MLB. MLB was consecutively administered into PIH rats for one week. The effects of MLB on mean arterial blood pressure (MAP), urine protein level, inflammation, and oxidative stress together with angiogenesis were analyzed. Results. MLB prevented the elevation in MAP and urine protein levels induced by L-NAME. The activities of inflammatory cytokines were highly increased in serum and placental tissues of PIH rats, while cotreatment with MLB partially reversed the activities of these cytokines. MLB also recovered the expression of reactive oxygen species (ROS) in plasma of PIH rats together with levels of oxidative stress and antioxidant capacity in the placenta of PIH rats. The decreased expressions of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and NO observed in PIH rats were increased by MLB. In addition, 10 mg/kg MLB exhibited higher protective effects as compared to lower doses of 5 mg/kg. Conclusion. This study demonstrated that pretreatment with MLB decreased MAP, inflammation, and oxidative stress in rats with gestational hypertension.

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“…A meta‐analysis by Veisian et al found that IL10 /rs1800896 AA genotype was associated with PE risk in several populations, especially in Asians 45 . Additionally, other studies elicited that the rs1800872 C allele and rs1800871 T allele might be associated with susceptibility to PE in Chinese and Tunisian women, respectively 46,47 …”

Section: Genetic Polymorphisms Of Pihmentioning

confidence: 99%

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

et al. 2022

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Pregnancy‐induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre‐existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH‐induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case‐control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin‐angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.

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Interleukin-10 rs1800871 (−819C/T) and ATA haplotype are associated with preeclampsia in a Tunisian population

Cited by 14 publications

References 44 publications

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Magnesium Lithospermate B Downregulates the Levels of Blood Pressure, Inflammation, and Oxidative Stress in Pregnant Rats with Hypertension

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

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