Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis

Abstract

ObjectiveAs an update to other recent meta-analyses, the purpose of this study was to explore whether interleukin-10 (IL-10) polymorphisms and their haplotypes contribute to tuberculosis (TB) susceptibility.MethodsWe searched for published case-control studies examining IL-10 polymorphisms and TB in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wanfang databases and the Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strengths of the associations.ResultsA total of 28 studies comprising 8,242 TB patients and 9,666 controls were included in the present study. There were no significant associations between the -1082G/A, -819C/T, and -592A/C polymorphisms and TB in the pooled samples. Subgroup analyses revealed that the -819T allele was associated with an increased TB risk in Asians in all genetic models (T vs. C: OR=1.17, 95% CI=1.05-1.29, P=0.003; TT vs. CC: OR=1.37, 95% CI=1.09-1.72, P=0.006; CT+TT vs. CC: OR=1.33, 95% CI=1.09-1.63, P=0.006; TT vs. CT+CC: OR=1.17, 95% CI=1.02-1.35, P=0.03) and that the -592A/C polymorphism was significantly associated with TB in Europeans under two genetic models (A vs. C: OR=0.77, 95% CI=0.60-0.98, P=0.03; AA vs. CC: OR=0.53, 95% CI=0.30-0.95, P=0.03). Furthermore, the GCC IL-10 promoter haplotype was associated with an increased risk of TB (GCC vs. others: P=1.42, 95% CI=1.02-1.97, P=0.04). Subgroup analyses based on ethnicity revealed that the GCC haplotype was associated with a higher risk of TB in Europeans, whereas the ACC haplotype was associated with a lower TB risk in both Asians and Europeans.ConclusionsThis meta-analysis suggests that the IL-10-819T/C polymorphism is associated with the risk of TB in Asians and that the IL-10-592A/C polymorphism may be a risk factor for TB in Europeans. Furthermore, these data indicate that IL-10 promoter haplotypes play a vital role in the susceptibility to or protection against the development of TB.

Identification of compounds that decrease numbers of Mycobacteria in human macrophages in the presence of serum amyloid P

“…M2 appear to be more associated with tuberculosis than M1 [43][44][45][46][47]. In agreement with this, we observed that compared with unpolarized human Mfs, human Mfs polarized to an M1 phenotype with IFN-g [48] showed decreased numbers of intracellular M. smegmatis at 48 h after infection and a decreased percentage of cells infected with M. tuberculosis at 5 d after infection (Fig.…”

Interleukin10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population

“…However, it is also involved in SLE pathogenesis, and several studies have reported the elevated levels of IL10 in exacerbated disorders (Godsell et al, ). It has been suggested that certain SNPs in the promoter region of IL10 could be associated with the elevated expression of its cytokine and increased susceptibility to various inflammatory and autoimmune disorders such as asthma (Gao et al, ), rheumatoid arthritis (RA) (Gambhir et al, ; Nemec et al, ) and SLE (Liu et al, ; Palafox‐Sánchez et al, ). In the present study, we evaluated the association of genotype and haplotype frequencies of three distinct IL10 gene promoter polymorphisms including −1082 (rs1800896), −819 (rs1800871) and −592 (rs1800872) with susceptibility to SLE, IL10 expression and disease activity of patients in an Iranian population.…”

Correlation between polymorphism (-1082) of interleukin-10 and the injury of development cancer of skin

“…(21,22) Os fatores genéticos do indivíduo também apresentam uma importância vital na patogênese de certas doenças, dentre ela os carcinomas, por afetarem a expressão dos níveis de citocinas e quimiocinas. (23) No presente estudo foi observada uma diferença significativa em relação à frequência do SNP IL-10 (-1082) entre as amostras controle e com carcinomas epitelial. Houve uma maior prevalência do alelo G e genótipos AG, GG nas amostras neoplásicas tanto basocelular, quanto espinocelular, enquanto que nas amostras controle houve um maior predomínio do genótipo AA.…”