Interleukin-10 Inhibits Spontaneous Sleep in Rabbits

Kushikata, Tetsuya; Fang, Jidong; Krueger, James M.

doi:10.1089/107999099313244

Cited by 53 publications

(45 citation statements)

References 29 publications

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“…Experimental evidence exists to support the notion of a cytokine/sleep network in which proinflammatory cytokines induce sleep and anti-inflammatory cytokines disturb sleep (13,14). The existence of this immunological homeostatic system controlling sleep led us to generate an alternative hypothesis to the proinflammatory one as a cause of CFS, namely, that disturbances in this cytokine/sleep network could lead to disturbed sleep with resulting fatigue.…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesized that CFS might result from an imbalance of this network in favor of the anti-inflammatory cytokines which are sleep disrupting (14). Supporting this possibility is the result of a recent study (28) in which we sampled blood for cytokines every 20 min across a 24-h day in patients with fibromyalgia (FM) (28), a medically unexplained, diffuse pain syndrome that has substantial overlap with CFS (5).…”

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confidence: 99%

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Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

Nakamura

Schwander

Donnelly

et al. 2010

Clin Vaccine Immunol

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The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an antiinflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.Chronic fatigue syndrome (CFS) is a medically unexplained illness lasting at least 6 months and characterized by severe fatigue that produces a substantial reduction in activity accompanied by at least four of the following symptoms: sore throat, tender lymph nodes, headache, myalgia, arthralgia, unrefreshing sleep, difficulty concentrating, and the report of syndromic exacerbation following mild exertion (7). One major hypothesis for the cause of CFS is an immune dysregulation of unknown etiology with high levels of proinflammatory cytokines producing the CFS symptom complex. Two findings fostered this idea: first, approximately a third of CFS patients report a sudden, influenza-like onset of their illness (37), and second, administration of proinflammatory cytokines leads to many of the same symptoms seen in CFS (26). However, we recently reviewed the literature on this hypothesis and found relatively little empirical data to support it (20); a more recent small study did report higher levels of one such cytokine, serum transforming growth factor ␤, in patients than in controls (35); however, another group did not confirm this result (30). Other work extending the research to cellular production of proinflammatory cytokines was also negative (1).However, a very different and alternative hypothesis focuses on the common complaint in CFS of unrefreshing sleep (4).Recent work suggests that sleep is under the control of a cytokine/sleep network where normal sleep follows a balanced secretion of pro-and anti-inflammatory cytokines (13). We hypothesized that CFS might result from an imbalance of this network in favor of the anti-inflammatory cytokines which are sleep disrupting (14). Supporting this possibility is the result of a recent study (28) in which we sampled blood for cytokines every 20 min across a 24-h day in patients with fibromyalgia (FM) (28), a medically unexplained, diffuse pain syndrome that has substantial overlap with CFS (5). Of several pro-and anti-inflammatory cytokines studied, the only one to show differences from controls, i.e., increases, was the anti-inflammatory cytokine interleukin-10 (IL-10), and that was true only for nocturnal dat...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

Nakamura

Schwander

Donnelly

et al. 2010

Clin Vaccine Immunol

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“…However, this was mostly concluded by the impact on sleep duration and sleep stage fractions in animal models [17,18,23]. In these, the administration of IL-10 and IL-13 reduced time spent asleep, probably by limiting the production of sleep-inducing TNF-α and IL-1 as well as interfering with transcription factor NF-κB [24,25,26,27,28]. Wake-promoting cytokines further peak in concentrations during daytime [29], levels of IL-10 reduce during sleep [30], sleep restriction leads to an increase in the IL-4 to IL-2 ratio [31] and insomniac men show higher levels of IL-4 than noninsomniac men [32].…”

Section: Introductionmentioning

confidence: 99%

Impact of Serum Cytokine Levels on EEG-Measured Arousal Regulation in Patients with Major Depressive Disorder and Healthy Controls

et al. 2016

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Background: In major depressive disorder (MDD), findings include hyperstable regulation of brain arousal measured by electroencephalography (EEG) vigilance analysis and alterations in serum levels of cytokines. It is also known that cytokines affect sleep-wake regulation. This study investigated the relationship between cytokines and EEG vigilance in participants with MDD and nondepressed controls, and the influence of cytokines on differences in vigilance between the two groups. Methods: In 60 patients with MDD and 129 controls, 15-min resting-state EEG recordings were performed and vigilance was automatically assessed with the VIGALL 2.0 (Vigilance Algorithm Leipzig). Serum levels of the wakefulness-promoting cytokines interleukin (IL)-4, IL-10, IL-13 and somnogenic cytokines tumor necrosis factor-α, interferon-γ and IL-2 were measured prior to the EEG. Results: Summed wakefulness-promoting cytokines, but not somnogenic cytokines, were significantly associated with the time course of EEG vigilance in the MDD group only. In both groups, IL-13 was significantly associated with the course of EEG vigilance. In MDD compared to controls, a hyperstable EEG vigilance regulation was found, significant for group and group × time course interaction. After controlling for wakefulness-promoting cytokines, differences in vigilance regulation between groups remained significant. Conclusions: The present study demonstrated a relationship between wakefulness-promoting cytokines and objectively measured EEG vigilance as an indicator for brain arousal. Altered brain arousal regulation in MDD gives support for future evaluation of vigilance measures as a biomarker in MDD. Since interactions between cytokines and EEG vigilance only moderately differed between the groups and cytokine levels could not explain the group differences in EEG vigilance regulation, cytokines and brain arousal regulation are likely to be associated with MDD in independent ways.

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“…Hypothalamische GHRH und CRH Neurone projizieren zur eminentia mediana (Larsen et al 1991), die zu den circumventriculären Organen gehört, die keine dichte Bluthirnschranke besitzen (Weindl 1973). Weiterhin sind in der eminentia mediana Rezeptoren für GHRH und CRH beschrieben worden (Takahashi et al 1995;Wong et al 1994 (Kushikata et al 1999;Opp et al 1995), das einerseits IL-1 hemmt und andererseits die hypothalamische CRH Sekretion stimuliert (Smith et al 1999). Somit scheinen pro-inflammatorische Zytokine, unter Einbeziehung von GHRH, Schlaf zu fördern, während anti-inflammatorische Zytokine über eine Stimulierung der CRH Sekretion gegenteilige Effekte ausüben können.…”

Section: Rem Schlaf Parameter Bei Patienten Mit Major Depression Auchunclassified

Geschlechtsspezifische Unterschiede der schlafendokrinen Regulation und deren Bedeutung für die Pathophysiologie der Major Depression

Antonijevic¹

2004

Monographien Aus Dem Gesamtgebiete Der Psychiatrie

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Interleukin-10 Inhibits Spontaneous Sleep in Rabbits

Cited by 53 publications

References 29 publications

Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

Impact of Serum Cytokine Levels on EEG-Measured Arousal Regulation in Patients with Major Depressive Disorder and Healthy Controls

Geschlechtsspezifische Unterschiede der schlafendokrinen Regulation und deren Bedeutung für die Pathophysiologie der Major Depression

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