Interleukin-10 Associates With Adiponectin Predominantly in Subjects With Metabolic Syndrome

Abstract

Background Inflammation and the metabolic syndrome (MetS) are important risk factors in cardiovascular disease. There is accumulating evidence that decreased adiponectin levels are associated with MetS. Recently, it was shown that adiponectin induces the expression of a potent anti-inflammatory cytokine, interleukin (IL)-10, in vitro. The aim of this study is to investigate the association of IL-10 levels with other pro-inflammatory and anti-inflammatory factors including adiponectin levels in vivo. Methods and Results MetS components were assessed in 117 drug-naïve middle-aged men. Serum levels of high-sensitive C-reactive protein (hs-CRP), IL-6, adiponectin, IL-10 and tumor necrosis factor-(TNF-) were measured in these subjects. A significant decrease in adiponectin (5.15±1.79 g/ml vs 6.87±3.55 g/ml, p<0.02) and an increase in IL-6 (1.50±1.50 pg/ml vs 1.06±0.78 pg/ml, p<0.05) levels were associated with MetS. The serum IL-10 level exhibited a significant positive correlation with IL-6, hs-CRP, and TNF-levels, but not with adiponectin in healthy individuals. However, IL-10 exhibited a significant correlation with adiponectin, especially in the subjects with MetS. Conclusions Serum IL-10 levels correlated with inflammatory proteins, but not with adiponectin. However, IL-10 positively associated with adiponectin especially in the subjects with MetS. IL-10 might be involved in the inflammatory network of MetS in relation to adiponectin. (Circ J 2007; 71: 1234 -1238

Pro12Ala Polymorphism of the Peroxisome ProliferatorActivated Receptor-.GAMMA. Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men Interaction With Smoking Status

“…37 Contrary to the evidence showing antiinflammatory properties of smoking in monocytemacrophages, most 38,39 but not all studies 40 have reported a negative correlation between cigarette smoking and adiponectinemia, a well-known antiinflammatory adipokine that increases PPARG and insulin sensitivity. However, the negative correlation between adiponectinemia and IR (and/or MetS) [41][42][43] has not always been observed. [44][45][46] In addition, it remains unclear whether hypoadiponectinemia is a consequence or cause of obesity, IR and MetS.…”

Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men

“…In the present study, we measured carotid artery inti-tudinal images (anterior oblique, lateral, and posterior oblique) of the left common carotid artery (CCA) of a 1.0-1.5 cm section at the distal end of the CCA proximal to the carotid bulb was obtained as described previously [15,16]. Mean IMT was obtained using computer software (IntimaScope, SoftMedical Co., Ltd, Tokyo, Japan) that automatically traces the intima-media edge of the far wall [17].…”

Small Dense LDL-Cholesterol Relative to LDL-Cholesterol is a Strong Independent Determinant of Hypoadiponectinemia in Metabolic Syndrome

“…However, the cause and effect relationship between the adiponection level and the ratio sd-LDL-C/LDL-C remains to be elucidated. 24 Interestingly, Jang et al reported that the presence of a G allele in the adiponectin gene at SNP 276 is correlated with greater oxidative stress, higher sd-LDL-C concentrations and smaller LDL particle size. 25 One of the mechanisms that link hypoadiponectinemia with the increase in the ratio sd-LDL-C/LDL-C might be insulin resistance caused by low adiponectin levels in MS patients.…”