Interleukin‐10 and transforming growth factor‐β1 in cord blood: relationship with paternal allergy and cesarean section

Balossini, Veronica; Monzani, Alice; Rapa, Anna; Vivenza, Daniela; Caristo, E.; Oderda, Giuseppina

doi:10.1111/j.1651-2227.2008.01194.x

Cited by 7 publications

(5 citation statements)

References 30 publications

(33 reference statements)

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“…However, TGFb1 levels of cord blood were not consistent and very different in the past reports [6][7][8][9]. To our knowledge, there has been no previous report of identification of a relationship between the serum level of TGFb in cord blood and the prevalence of neonatal complications.…”

Section: Introductioncontrasting

confidence: 66%

“…Briana et al reported that the 50th percentile of TGFb1 was around 5000 pg/ml in both appropriate for gestational age and intrauterine growth restriction infants [7]. Balossini et al reported an interquartile range of 29,500-55,100 pg/ml of TGFb1 in cord blood [8], and Hrd et al reported an interquartile range of 24,512 and 103,040 pg/ml of TGFb in cord blood from newborns of healthy mothers [9]. The variety of these results might be influenced by the method used to measure the serum level of TGFb.…”

Section: Constitutively Extremely High Level Of Tgfb1 and Tgfb2 Exprementioning

confidence: 96%

See 1 more Smart Citation

Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings

Takahashi

Kobayashi

et al. 2015

Cytokine

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Section: Introductioncontrasting

confidence: 66%

Section: Constitutively Extremely High Level Of Tgfb1 and Tgfb2 Exprementioning

confidence: 96%

Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings

Takahashi

Kobayashi

et al. 2015

Cytokine

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“…In a genome wide scan of ADHD subjects [34], 2 SNPs were associated with the inattentive phenotype. While IL-16 levels did not differ between the groups studied, they correlated positively and IL-10 levels correlated negatively with the experience of allergy across all subjects: (see [91] on low IL-10 transmission reflecting paternal allergy). Exactly paralleling this were similar correlations with S100B.…”

Section: Discussionmentioning

confidence: 99%

Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism - effects of medication

et al. 2010

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BackgroundChildren with attention-deficit/hyperactivity disorder (ADHD) show a marked temporal variability in their display of symptoms and neuropsychological performance. This could be explained in terms of an impaired glial supply of energy to support neuronal activity.MethodWe pursued one test of the idea with measures of a neurotrophin reflecting glial integrity (S100B) and the influences of 8 cytokines on the metabolism of amino-acids, and of tryptophan/kynurenine to neuroprotective or potentially toxic products that could modulate glial function. Serum samples from 21 medication-naïve children with ADHD, 21 typically-developing controls, 14 medicated children with ADHD and 7 healthy siblings were analysed in this preliminary exploration of group differences and associations.ResultsThere were no marked group differences in levels of S100B, no major imbalance in the ratios of pro- to anti-inflammatory interleukins nor in the metabolism of kynurenine to toxic metabolites in ADHD. However, four trends are described that may be worthy of closer examination in a more extensive study. First, S100B levels tended to be lower in ADHD children that did not show oppositional/conduct problems. Second, in medicated children raised interleukin levels showed a trend to normalisation. Third, while across all children the sensitivity to allergy reflected increased levels of IL-16 and IL-10, the latter showed a significant inverse relationship to measures of S100B in the ADHD group. Fourthly, against expectations healthy controls tended to show higher levels of toxic 3-hydroxykynurenine (3 HK) than those with ADHD.ConclusionsThus, there were no clear signs (S100B) that the glial functions were compromised in ADHD. However, other markers of glial function require examination. Nonetheless there is preliminary evidence that a minor imbalance of the immunological system was improved on medication. Finally, if lower levels of the potentially toxic 3 HK in ADHD children were confirmed this could reflect a reduction of normal pruning processes in the brain that would be consistent with delayed maturation (supported here by associations with amino-acid metabolism) and a reduced metabolic source of energy.

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“…Cesarean section was associated with reduced pro-inflammatory cytokine responses to TLR1/2 stimulation, followed by an increased abundance of bacterial colonization in the airway during late infancy, therefore increasing the risk of infantile wheezing (48). Levels of transforming growth factor (TGF)-β1 were lower in newborns following cesarean section (49). Hence, newborns born through vaginal delivery and exposed to higher levels of TGF-β1 may exhibit more protection toward atopy at later life, potentially reflecting the capacities of TGF-β1 to skew the production of IgE toward non-inflammatory isotypes IgG4 and IgA (50).…”

Section: Maternal Protective Influences Over Offspring Allergymentioning

confidence: 99%

Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy

et al. 2019

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The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. The first known ingestion of foods often causes allergic reaction, suggesting that sensitization of offspring with food allergens may occur during pregnancy and/or through breastfeeding. This creates a milieu that shapes the neonatal immune responses to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances from human data in our understanding of how maternal factors, namely, food allergens, allergen-specific immunoglobulins, cytokines, genetics, and environmental factors transferred during pregnancy or breastfeeding influence offspring allergies and how such effects may be applicable to food allergy. Based on information obtained from mouse models of asthma and food allergy, the review also dissects the mechanisms by which maternal factors, including the impact of immune complexes, transforming growth factor-β, vitamin A, and regulatory T-cell responses, contribute to the induction of neonatal tolerance vs. development of allergic responses to maternally transferred allergens.

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Interleukin‐10 and transforming growth factor‐β1 in cord blood: relationship with paternal allergy and cesarean section

Abstract: Paternal allergy and cesarean section are associated to decreased TGF-beta1, which might be the mediator of the increased risk of atopy development. Cord blood IL-10 and TGF-beta1 levels of our newborn series could be used as reference values for further studies on these relationships.

Cited by 7 publications

References 30 publications

Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings

Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings

Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism - effects of medication

Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy

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