Interleukin-10

Abstract

In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector functions of macrophages, T cells, and NK cells. In addition, IL-10 likely contributes to regulating proliferation and differentiation of B cells, mast cells, and thymocytes. The Epstein-Barr virus genome encodes a homolog of IL-10 (BCFR1, viral IL-10, vIL-10) which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction. This article reviews current studies of IL-10's biological activities and discusses its possible roles in regulation of immune responses.

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

“…At high power (i), some of the epithelioid macrophages can be seen to contain acidfast bacilli (arrows). 374,213,156,19,181,415,493,218,196,265,396,425,D11Mit226,19,20,349,194,39,67,224,103 109,145,206,541,150,361,221,209 D12Mit12,153,34,14,118,233,20 D2Mit1,32,367,61,91,436,164,401,225,311,200 D13Mit271,60,139,250,145,293,35 D3Mit176,306,69,241,51,72,156,106,17,128 D14Mit207, …”

Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins

“…To contrast with this potential for enhancement of the immune response, we selected IL-10 due to its known capacity to suppress host immune responses. 32 As noted in the Introduction, the expectation was that if the cytokines were not expressed or if the immune system played little or no role in tumor progression, the median survival of tumor-bearing mice treated with cytokine-expressing virus would be similar to that of mice treated with noncytokine expressing virus.…”

Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

“…IL-10 is a cytokine synthesis inhibitory factor that balances the TH1 and TH2 immune response, and is involved in many aspects of human disease. 22,23 There is strong evidence for a substantial genetic component in IL-10 production. 24,25 The IL10 gene has been implicated in the response to a number of diseases such as hepatitis B, pulmonary tuberculosis, herpes zoster, cutaneous malignant melanoma, hepatocellular carcinoma fibrosis, gastric carcinoma, squamous cell carcinoma, inflammatory bowel disease, and HIV.…”