Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility

Abstract

The A allele of the -1082 polymorphism in the interleukin-10 gene promoter is associated with sepsis susceptibility, whereas G allele is associated with higher stimulated interleukin-10 production and increased mortality in severe sepsis.

The influence of genetic variation on innate immune activation in an environment with high infectious pressure

“…12 Heterogeneity between studies regarding stimulants used, incubation times, and whether wholeblood samples or peripheral blood mononuclear cells were stimulated, hampers comparisons between studies. However, in general, our results are in line with most previous studies suggesting an increased IL-10 production with rs1800896G and a decreased IL-10 production with rs1800871T and rs1800872A, [13][14][15][16][17][18][19][20][21][22] although there are also studies reporting on opposite results. [23][24][25] Taking into account the 2-year interval between measurements and the field conditions in which samples were collected and the stimulation assay was performed, we consider the repeated measurements to correlate well, especially for IL-10.…”

Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients

“…More interestingly, a decrease in liver fibrosis has been observed in chronic hepatitis C patients treated with recombined IL-10 [19,20]. Polymorphism at position -1082 of IL-10 gene was reported to have an independent influence on IL-10 production [59][60][61][62]. The -1082AA genotype was associated with a low IL-10 production and with a higher risk of a worse clinical progression of HCV or HBV infection [29,31].…”

Polymorphisms in TNFA and IL10 gene promoters and risk of rheumatoid arthritis in Bulgarian population

“…PCR amplification was performed in a GeneAmp PCR System 9700 (Applied Biosystems) as described by Stanilova et al (12). PCR products were visualized on a 2 % agarose gel stained with ethidium bromide (0.5 mg/ml).…”