2004
DOI: 10.1097/01.mco.0000134373.16557.92
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Interleukin-1?? system in anorectic catabolic tumor-bearing rats

Abstract: This suggests that IL-1beta and its receptor may play a significant role in this model of cancer-associated anorexia. In vivo, the characterization of cytokine components in the brain may provide data for potential pharmacological interventions to ameliorate the anorexia of disease.

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Cited by 44 publications
(28 citation statements)
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References 37 publications
(43 reference statements)
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“…Elevations in proinflammatory cytokines (IL-1␤, IL-6, and TNF-␣) have been associated with experimental and clinical anorexia (26,35,43,60) and with increased resting energy expenditure in patients with end-stage renal disease and human immunodeficiency virus infection (27,50). Ghrelin has been used with success to treat both animals and humans with conditions that are associated with elevated cytokine levels, such as cancer cachexia (9,22,42), cardiac cachexia (14, 38 -41), lipopolysaccharide injection (63), sepsis (69), renal failure (55), and chronic kidney disease (8).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Elevations in proinflammatory cytokines (IL-1␤, IL-6, and TNF-␣) have been associated with experimental and clinical anorexia (26,35,43,60) and with increased resting energy expenditure in patients with end-stage renal disease and human immunodeficiency virus infection (27,50). Ghrelin has been used with success to treat both animals and humans with conditions that are associated with elevated cytokine levels, such as cancer cachexia (9,22,42), cardiac cachexia (14, 38 -41), lipopolysaccharide injection (63), sepsis (69), renal failure (55), and chronic kidney disease (8).…”
Section: Discussionmentioning
confidence: 99%
“…Elevated levels of proinflammatory cytokines are associated with anorexia in humans and animals (26,27,35,43,50,60). Ghrelin has been shown to decrease both proinflammatory cytokine levels in the plasma of an arthritic rat model as well as the chronic kidney failure model, and in proinflammatory cytokine production by cultured human cells (8,12,28,63).…”
mentioning
confidence: 99%
“…In patients with OGC, a number of primary and secondary causes of reduced dietary intake are at work simultaneously, including dysphagia (McKernan et al, 2008), early satiety (Davis et al, 2006), chronic nausea (McKernan et al, 2008), alterations in circulating neuroendocrine hormones (e.g., ghrelin (Isomoto et al, 2005) and leptin (Huang et al, 2005;Zhao et al, 2007)), hypogeusia/hyposmia (Plata-Salaman, 2000), and cytokine-induced central anorexia (Plata-Salaman, 2001;Turrin et al, 2004). Assuming that MIC-1 may be a modulator of appetite in humans, the complex constellation of additional factors also controlling food intake may explain why plasma MIC-1 concentrations did not correlate with nutritional status in this study.…”
Section: Crp (Mg Lmentioning
confidence: 99%
“…IL-1b and leptin (98) decrease the expression of ghrelin mRNA in the stomach, whereas IL-6 produced in various cells, including adipocytes, regulates leptin production (99). These findings suggest that cytokines have an important role in energy balance through the persistent activation of the leptin system and the inhibition of the ghrelin-NPY/agouti-related peptide orexigenic network in tumor-bearing rats (87).…”
Section: Rikkunshito As An Activator Of Ghrelin Signalingmentioning
confidence: 60%