Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese

Kamei, Hidehiko; Ishihara, Yuichi; Fuma, Daisuke; Niwa, Takafumi; Kamiya, Yosuke; Yokoi, Takamasa; Suzuki, Masataka; Izawa, Ario; Mizutani, Hiroki; Hayashi, Jun-ichiro; Sakaki, Yoshiyuki; Noguchi, Toshihide; Kojima, Toshio

doi:10.1016/j.archoralbio.2014.04.006

Cited by 11 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…) and IL1R1 (Kamei et al. ). In addition, LIF had earlier been shown to be down‐regulated in periodontitis (Becerik et al.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, numerous genes had also previously been recognized being involved in periodontal disease, including, e.g. HGF (Ohshima et al 2001, 2002, Ohnishi & Daikuhara 2003, WNT5A (Divaris et al 2013), MMP-3 (Ohshima et al 2010), regulator of G-protein signalling 4 (RGS4) (Davanian et al 2012, Kebschull et al 2014) and IL1R1 (Kamei et al 2014). In addition, LIF had earlier been shown to be downregulated in periodontitis (Becerik et al 2012, Souza et al 2012, being in line with our results, whichtaken togethersuggests that reliable material had been yielded.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fibroblast VEGF‐receptor 1 expression as molecular target in periodontitis

Ohshima

Yamaguchi

Ambe

et al. 2016

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…) and IL1R1 (Kamei et al. ). In addition, LIF had earlier been shown to be down‐regulated in periodontitis (Becerik et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fibroblast VEGF‐receptor 1 expression as molecular target in periodontitis

Ohshima

Yamaguchi

Ambe

et al. 2016

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…Therefore, IL-1R2 gene was selected as the candidate gene in our study. Some studies reported the relation of IL-1R2 genetic variants to various in ammatory diseases, such as rheumatoid arthritis and aggressive periodontitis [25,26], but not osteoporosis. Here, our study rstly explored the correlation of IL-1R2 variants with osteoporosis susceptibility.…”

Section: Discussionmentioning

confidence: 99%

IL-1R2 Polymorphisms and its Interaction Associates With Osteoporosis Susceptibility in Chinese Han Population

Rong¹,

Liang

Xiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: IL-1R2, serves as a negative regulator of IL-1 signaling, is involved in the pathogenesis of osteoporosis. This study aimed to determine the correlation between IL-1R2 polymorphism and osteoporosis susceptibility among the Chinese Han population.Methods: We recruited 594 osteoporosis patients and 599 healthy controls. Six single nucleotide polymorphisms (SNPs) in IL-1R2 were selected for genotyping using Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) was calculated through logistic regression analysis with adjustment for age and sex. Linkage disequilibrium analysis was plotted by Haploview v4.2. Multifactor dimension reduction (MDR) was performed to estimate the SNP-SNP interaction of IL-1R2 variants.Results: Our result revealed that rs11674595 (OR = 1.86, p = 0.020), rs2072472 (OR = 1.26, p = 0.019) and rs4851527 (OR = 0.78, p = 0.007) were related to the risk of osteoporosis. Moreover, the contribution of IL-1R2 polymorphisms to osteoporosis risk presented age, sex and BMI difference. We found the relationship of Trs11674595Ars4851527 (OR = 0.80, p = 0.015), Crs11674595Grs4851527 (OR = 1.22, p = 0.043) and Ars3218977Grs2072472 (OR = 1.25, p = 0.022) haplotypes to osteoporosis occurrence, and a potential accumulated effect of IL-1R2 SNPs (testing accuracy = 0.5783 and CVC = 10/10) on osteoporosis susceptibility.Conclusion: IL-1R2 polymorphisms (rs11674595, rs4851527, rs2072472 and rs3218977) might contribute to osteoporosis risk among the Chinese Han population. Our finding may increase our understanding of the effects of IL-1R2 polymorphisms on the predisposition of osteoporosis.

show abstract

“…Previous study reported that rs3218977 was found to be associated with a 0.71‐fold decrease risk of IgA nephropathy in the dominant model (GA‐GG vs. AA) (Xie et al, ). A case‐control association study found that the SNP rs3218977 was associated with an increased risk of aggressive periodontitis in the additive model in the Japanese (Kamei et al, ). However, rs3218977 was associated with an increased risk of tuberculosis in the dominant model (Ren et al, ).…”

Section: Discussionmentioning

confidence: 99%

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Zhang

Cai

et al. 2019

Molec Gen & Gen Med

View full text Add to dashboard Cite

Background Recently, many studies have identified that genetic factor plays a crucial role in endometrial cancer development. The purpose of this study is to investigate the influence of single nucleotide polymorphisms (SNPs) of IL‐1R2 on endometrial cancer susceptibility. Methods We performed a case‐control study that included 293 patients with endometrial cancer and 579 healthy controls. Six SNPs in the IL‐1R2 gene were genotyped using the Agena MassARRAY platform. Genetic models and haplotype analyses were used to assess the association between SNPs and endometrial cancer risk by computing odds ratios (ORs) and 95% confidence intervals (CIs). Results Overall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk. Stratified analysis by age showed that rs2072472 was associated with endometrial cancer risk in age >54 subgroup. Conclusions These findings suggested that IL‐1R2 polymorphisms may contribute to the development of endometrial cancer. Further studies are required to confirm the results.

show abstract

Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese

Cited by 11 publications

References 25 publications

Fibroblast VEGF‐receptor 1 expression as molecular target in periodontitis

Fibroblast VEGF‐receptor 1 expression as molecular target in periodontitis

IL-1R2 Polymorphisms and its Interaction Associates With Osteoporosis Susceptibility in Chinese Han Population

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Contact Info

Product

Resources

About