Interleukin‐1 receptor‐associated kinase 1 correlates with metastasis and invasion in endometrial carcinoma

Wang, Yilin; Wang, Yanyan; Duan, Xiaohui; Wang, Yinuo; Zhang, Zhenyu

doi:10.1002/jcb.26416

Cited by 24 publications

(18 citation statements)

References 19 publications

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“…AURKB plays a central role in mitosis and participates in the division of cells from G2 phase to M phase [ 25 , 26 ]. The expression of the mitotic cell cycle (CDK1) was significantly suppressed by IRAK1 knockdown [ 27 ]. In UCEC, ZBTB7A may regulate cell cycle progression via interacted kinases.…”

Section: Disscusionmentioning

confidence: 99%

ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments

et al. 2020

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Backgroud ZBTB protein is an important member of the C2H2 zinc finger protein family. As a transcription factor, it is widely involved in the transcriptional regulation of genes, cell proliferation, differentiation, and apoptosis. The ZBTB7A has been largely linked to different kinds of tumors due to its diverse function. However, the value for ZBTB7A in uterine corpus endometrial carcinoma (UCEC) is unclear. Methods In our work, we assessed the importance of ZBTB7A in UCEC. Firstly, Using Oncomine and Tumor Immunoassay Resource (TIMER) databases to evaluate the expression of ZBTB7A. Secondly, we explored the co-expression network of ZBTB7A through the cBioPortal online tool, Metascape, and LinkedOmics. TIMER was also used to explore the relationship between ZBTB7A and tumor immune invasion, and to detect the correlation between the ZBTB7A and the marker genes related to immune infiltration. Finally, CCK8, migration, ChIP assays were introduced to partly validate ZBTB7A function in endometrial cancer cells. Results We found the ZBTB7A expression in TIMER was associated with various cancers, especially UCEC. The decreased expression of ZBTB7A was markedly related to the stage and prognosis of UCEC. Furthermore, ZBTB7A was also related to the expression of various immune markers such as Neutrophils, Dendritic cell, T cell (general), Th1, Th2, and Treg. Finally, we verified that ZBTB7A repressed E2F4 transcription and inhibited cells proliferation and migration. These results indicate that ZBTB7A may play a vital role in regulating immune cell infiltration in UCEC, and is a valuable prognostic marker. Conclusions In summary, we demonstrate that ZBTB7A is notably downregulated in UCEC, plays a vital role in regulating immune cell infiltration, possesses diagnostic and prognostic values and attenuates E2F4 transcription and cell proliferation, migration in vitro.

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Section: Disscusionmentioning

confidence: 99%

ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments

et al. 2020

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“…IL-1 involvement is also implicated in some gynecologic cancers; in endometrial cancer (EC) IL-1R-associated kinase 1 (IRAK1) expression was shown to be elevated in EC compared with normal tissues, correlating with worse staging, metastasis, invasiveness, and low survival rate [ 74 ]. IL-1β/IL-1RI expression was found to be elevated in both cancer epithelial and stromal cells in samples from ovarian cancer patients, leading to repression of p53 tumor suppressor and correlated with reduced overall survival [ 75 ].…”

Section: Il-1 Dysregulation and Its Contribution To Cancer And Tumorimentioning

confidence: 99%

The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice

2018

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Interleukin-1 (IL-1) has long been known to be a key mediator of immunity and inflammation. Its dysregulation has been implicated in recent years in tumorigenesis and tumor progression, and its upregulation is thought to be associated with many tumors. Overexpression of the IL-1 agonists IL-1a and IL-1b has been shown to promote tumor invasiveness and metastasis by inducing the expression of angiogenic genes and growth factors. IL-1 blockers such as anakinra and canakinumab are already approved and widely used for the treatment of some autoimmune and autoinflammatory diseases and are currently being tested in preclinical and human clinical trials for cancer therapy. In this paper we review the most recent discoveries regarding the association between IL-1 dysregulation and cancer and present the novel IL-1 blockers currently being tested in cancer therapy and their corresponding clinical trials.

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“…A panel of cell-cycle-associated genes was derived from the KEGG pathway database ( http://www.kegg.jp/kegg/ ), as previously described [ 14 ]. In total, 124 genes were listed; however, mRNA expression data of genes MYC and CCND1 were unobtainable, and the remaining 122 candidate genes were analyzed (Additional file 1 : Table S1).…”

Section: Methodsmentioning

confidence: 99%

Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma

et al. 2018

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BackgroundGastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) is the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on the clinical significance of gene clusters of the cell cycle.MethodsWe investigated the genetic profile of cell-cycle-associated genes in a GAC cohort. The mRNA expression and clinical data were downloaded from TCGA, according to cBioportal. We conducted a series of analyses to detect the relationships between these genes and GAC.ResultsFrom all the patients, 5 clusters were identified based on mRNA expression of 122 cell-cycle-associated genes. Cluster 1 showed the worst prognosis and is characterized by extremely high expression of WEE2 and CCNE1. Comparison of the gene patterns showed that 16 genes expressed were distinctly varied between each cluster. In addition, investigations into the prognostic role of the 16 genes suggested that high expression of ESPL1 and MCM5 were significantly correlated with favorable outcomes. Moreover, we detected that ESPL1 and MCM5 gene expression were negatively correlated with GAC pathologic stage progression.ConclusionsThis study revealed a gene expression pattern of the cell cycle in different GAC subgroups, and suggested individual genes were associated with the clinical outcome and AJCC stages. These results suggest a novel prognostic strategy for GAC and provide information for patient stratification and trials of targeted therapies.Electronic supplementary materialThe online version of this article (10.1186/s12876-018-0811-1) contains supplementary material, which is available to authorized users.

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Interleukin‐1 receptor‐associated kinase 1 correlates with metastasis and invasion in endometrial carcinoma

Cited by 24 publications

References 19 publications

ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments

ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments

The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice

Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma

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