Interleukin-1 receptor antagonist prevents embryonic implantation by a direct effect on the endometrial epithelium

Simón, Carlos; Valbuena, Diana; Krüssel, Jan-Steffen; Bernal, A.; Murphy, Christopher R.; Shaw, Tim; Pellicer, A.; Polan, Mary Lake

doi:10.1016/s0015-0282(98)00275-1

Cited by 115 publications

(78 citation statements)

References 28 publications

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“…In addition, the in vitro culture of human embryos in GM-CSF demonstrated that GM-CSF has a positive effect on the development of embryos to the blastocyst stage by increasing the number of cells in the inner cell mass and in the trophectoderm (Sjöblom et al 1999). Many other cytokines have been studied extensively in mice and other mammalian species, including IL-1, , colony-stimulating factor 1 (CSF1) and anti-inflammatory cytokines of the transforming growth factor b family, because there is strong evidence that some of them are directly involved in the production of male and female gametes, embryo implantation and development (Sharkey 1998;Simón et al 1998;Hedger and Meinhardt 2003;Robertson et al 2007).…”

Section: Cytokine-cytokine Receptor Interactionmentioning

confidence: 99%

Implication of transcriptome profiling of spermatozoa for stallion fertility

Suliman

Becker

Wimmers

2018

Reprod. Fertil. Dev.

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Abstract. Poor fertility of breeding stallions is a recognised problem in the equine industry. The aim of the present study was to detect molecular pathways using two groups of stallions that differed in pregnancy rates as well as in the proportion of normal and motile spermatozoa. RNA was isolated from spermatozoa of each stallion and microarray data were analysed to obtain a list of genes for which transcript abundance differed between the groups (P #0.05, fold change $1.2). In all, there were 437 differentially expressed (DE) genes between the two groups (P # 0.05, fold change $1.2). Next, the DE genes were analysed using Database for Annotation, Visualisation, and Integrated Discovery (DAVID). Finally, ingenuity pathways analysis (IPA) was used to identify top biological functions and significant canonical pathways associated with the DE genes. Analysis using the DAVID database showed significant enrichment in the gene ontology (GO) term 'RNA binding' (P ¼ 0.05) and in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway cytokinecytokine receptor interaction (P ¼ 0.02). Furthermore, IPA analysis showed interconnected biological functions and canonical pathways involved in the regulation of spermatogenesis and male fertility. In addition, significantly enriched metabolic pathways were identified. In conclusion, the present study has identified, for the first time, molecular processes in stallion spermatozoa that could be associated with stallion fertility.

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Section: Cytokine-cytokine Receptor Interactionmentioning

confidence: 99%

Implication of transcriptome profiling of spermatozoa for stallion fertility

Suliman

Becker

Wimmers

2018

Reprod. Fertil. Dev.

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“…15 The IL-1 system may be involved in the regulation of Th1/Th2 cytokine production, since IL-1 can function as a costimulator for Th2 cell generation in both rodents and humans [16][17][18][19] and may influence IFN-␥ production mediated by natural killer (NK) and T cells. 20,21 Moreover, IL-1 has been implicated in implantation, 22 and trophoblast growth and invasion. 23 It was recently reported that levels of IL-1␤ mRNA were decreased in the endometrium of women with a history of recurrent pregnancy loss.…”

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confidence: 99%

T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region

et al. 2002

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Recurrent pregnancy loss (RPL) is a common disorder during early gestation. Recent evidence suggests that T helper 1 (Th1)-type immunity is associated with unsuccessful pregnancy especially in women with RPL of otherwise unknown etiology, while Th2-type immunity is associated with pregnancy success. Interleukin (IL)-1 may influence Th1/Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. In the present study, we investigated polymorphism of the IL-1␤ gene (IL1B) in women with a history of RPL. Significant increases in the frequencies of IL1B promoter region variants IL1-511C and IL1B-31T were found in women with a history of RPL. Increased frequencies of these two variants and their homozygotes were found only in cases having evidence of Th1 immunity to trophoblast as determined by IFN-␥ production of peripheral blood mononuclear cells (PBMCs) stimulated with a trophoblast cell-line extract. Significantly higher IFN-␥ production by PBMCs in response to trophoblast correlated with variant IL1B-511C and its homozygocity in women with RPL. These results suggest that variants −511C and −31T in the IL1B promoter region confer risk for RPL associated with Th1 immunity to trophoblast antigens.

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“…In addition, IL1β is expressed within the placenta of mammalian and non-mammalian vertebrates such as squamite reptiles (Paulesu et al 2005). In some placental mammals, including primates, rodents, and pigs, considerable IL1 cross talk occurs between the conceptus and endometrium during implantation (Simón et al 1998, Ross et al 2003a, Mathew et al 2015.…”

Section: Il1 and Reproductionmentioning

confidence: 99%

“…They also mediate communication between the early conceptus and endometrium, promoting implantation and establishment of pregnancy (Simón et al 1998, Ross et al 2003a, Granot et al 2012. Recent clinical observations made during human embryo transfer may reflect the importance of a proinflammatory environment at the site of embryo implantation.…”

Section: Introductionmentioning

confidence: 99%

“…Studies on primates and rodents indicate that the early embryo releases interleukin-1 beta (IL1β), increasing adhesion molecule expression within the endometrium and invasive characteristics of the cytotrophoblast (Librach et al 1994, Simón et al 1998. The pig is unique in that the IL1B gene is duplicated, resulting in a novel gene and conceptus form of IL1β (interleukin-1 beta 2; IL1β2) (Vandenbroeck et al 1993, Groenen et al 2012, Mathew et al 2015.…”

Section: Introductionmentioning

confidence: 99%

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Interleukins, interferons, and establishment of pregnancy in pigs

Mathew¹,

Lucy²,

Geisert³

2016

Reproduction

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Early pregnancy in mammals requires complex and highly orchestrated cellular and molecular interactions between specialized cells within the endometrium and the conceptus. Proinflammatory cytokines are small signaling proteins released by leukocytes that augment innate and adaptive immune responses. They are also released by the mammalian trophectoderm as the conceptus apposes the uterine surface for implantation. On approximately day 12 of development in pigs, the conceptus undergoes a rapid morphological transformation referred to as elongation while simultaneously releasing estrogens and a novel conceptus form of interleukin-1 beta (IL1β). Following elongation, pig conceptuses express interferon gamma (IFNγ) and, in lesser amounts, interferon delta (IFNδ). Significant IFN signaling takes place within the endometrium between day 14 and 18 of pregnancy as the conceptus intimately associates with the uterine epithelium. Based on studies carried out in pigs and other mammals, the combined spacio-temporal activities of conceptus estrogens, IL1β, and IFN set in motion a series of coordinated events that promote establishment of pregnancy. This is achieved through enhancement of conceptus development, uterine receptivity, maternal-fetal hemotropic exchange, and endometrial leukocyte function. These events require activation of specific signaling pathways within the uterine luminal epithelium, glandular epithelium, and stroma. Here, we review proinflammatory cytokine expression by pig conceptuses and the hypothesized actions of these molecules during establishment of pregnancy.Reproduction (2016) 151 R111-R122

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Interleukin-1 receptor antagonist prevents embryonic implantation by a direct effect on the endometrial epithelium

Cited by 115 publications

References 28 publications

Implication of transcriptome profiling of spermatozoa for stallion fertility

Implication of transcriptome profiling of spermatozoa for stallion fertility

T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region

Interleukins, interferons, and establishment of pregnancy in pigs

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