Interleukin‐1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity

Swellam, Menha; Gabal, Khadiga M. Abu; Youssef, Samar Samir

doi:10.1002/iub.1205

Cited by 11 publications

(9 citation statements)

References 26 publications

(31 reference statements)

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“…15 It is found that experimental hepcidin increase in humans, induced by IL-6 infusion, is accompanied by a decrease in serum iron levels. 20 Swellam et al 24 found that hepcidin is significantly correlated with laboratory anemia profile indicating that hepcidin binds to, and degrades ferroportin, thus reduces intestinal absorption of iron and blocks mobilization of iron from macrophages and hepatocytes, causing low serum iron and anemia through decreased iron reutilization.…”

Section: Discussionmentioning

confidence: 99%

Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin

Khalaf¹,

Al-Rubaie

Shihab

2019

Hematology Reports

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Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most important types of anemia in rheumatoid arthritis (RA). Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis. The aim is to investigate the role of circulating hepcidin and to uncover the frequency of IDA in RA. The study included 51 patients with RA. Complete blood counts, serum iron, total iron binding capacity, ferritin, and hepcidin- 25 were assessed. ACD was found in 37.3% of patients, IDA in 11.8%, and combined (ACD/IDA) in 17.6%. Serum hepcidin was higher in ACD than in control and the other groups (P≤0.001). It was strongly and positively correlated with ferritin (P<0.001), while hemoglobin, serum iron, and total iron binding capacity were negatively correlated with hepcidin (P=0.016, 0.022 and <0.001, respectively). High serum hepcidin was significantly associated with ACD in RA. IDA alone or combined with ACD was encountered in about a third of patients.

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Section: Discussionmentioning

confidence: 99%

Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin

Khalaf¹,

Al-Rubaie

Shihab

2019

Hematology Reports

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“…A few studies have consistently pointed out the role of IL-Ra gene polymorphism in the disease activity of RA. For instance, RA patients with persistent active disease, had significantly increased expression of IL-1RN*1 and IL-1RN*2 [ 25 ]. Apart from that, another study which involved Spanish RA patients also found a significant association between homozygosity for IL1RN*2 with increased number of affected joints [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of Interleukin–1 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis

et al. 2016

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ObjectiveInterleukin-1 receptor antagonist (IL-1Ra) acts as an inhibitor of IL-1; which is one of the culprit cytokines in rheumatoid arthritis (RA). Although +2018 polymorphism of IL-1Ra has been implicated in the pathogenesis of RA, its importance remains poorly understood. Hence, the purpose of this study was to determine the clinical significance of interleukin-1 receptor antagonist (IL-1Ra) +2018 polymorphism in RA.MethodsPolymerase chain reaction (PCR) and sequencing were used to determine the genotypes of the IL-1Ra +2018 for 77 RA patients and 18 healthy controls. All RA patients were assessed for the disease activity score that includes 28 joints (DAS28) and radiographic disease damage based on Modified Sharp Score (MSS).ResultsThe frequency of the T/T and C/T genotypes did not differ significantly (p = 0.893) between the RA patients and the controls. The C/T genotype had significantly higher mean disease activity (DAS 28) and disease damage (MSS) scores with p values of 0.017 and 0.004, respectively. Additionally, the ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), the number of swollen and tender joints were higher for the C/T individuals. On multivariate analysis the CRP, swollen joint count and MSS remained significant with the following p values i.e. 0.045, 0.046 and less than 0.05.ConclusionsC/T genotype of IL-1Ra +2018 prognosticates more aggressive disease in RA.

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“…In prostate cancer patients, the serum concentrations of Follistatin have been shown to significantly correlate with the presence of bone metastases (P = 0.0005) [29]. Five of the 29 proteins have been reported to be associated with orthopedic disease: 1) The hepcidin gene showed a significant correlation with the RA disease activity parameters [30]. 2) Thioredoxin was a biomarker for oxidative stress in patients with rheumatoid arthritis [31].…”

Section: Results Of Go Analysis Of the Differentially Proteinsmentioning

confidence: 99%

Early urine proteome changes in an implanted bone cancer rat model

Wang

Qin

et al. 2019

Preprint

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In this study, Walker 256 cells were implanted into rat tibiae. Urine samples were then collected on days 3, 5, 7, and 13 and were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins were found to change significantly in the urine of the tumor group mice compared with the proteins in the urine of the control group mice; this was even the case when there were no significant lesions identified in the Computed Tomography(CT) examination. Among these differentially proteins, 7 were reported to be associated with tumor bone metastasis. GO analysis shows that the differential proteins on day 3 were involved in several responses, including the acute phase response, the adaptive immune response and the innate immune response. The differentially proteins on day 7 were involved in the mineral absorption pathway. The differentially proteins on day 13 were involved in vitamin D binding and calcium ion binding. These processes may be associated with bone metastasis. Our results demonstrate that urine could sensitively reflect the changes in the early stage of implanted bone cancer; this provides valuable clues for future studies of urine biomarkers for tumor bone metastasis.

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Interleukin‐1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity

Abstract: Rheumatoid arthritis (RA)

Cited by 11 publications

References 26 publications

Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin

Studying Anemia of Chronic Disease and Iron Deficiency in Patients with Rheumatoid Arthritis by Iron Status and Circulating Hepcidin

The Clinical Significance of Interleukin–1 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis

Early urine proteome changes in an implanted bone cancer rat model

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