Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects

Kok, Yung-Yean; Ong, Hing-Huat; Say, Yee‐How

doi:10.1155/2017/4104137

Cited by 10 publications

(11 citation statements)

References 41 publications

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“…It was recently discovered that IL‐22 is associated with obesity and type 2 diabetes . Variants in the gene encoding IL‐1RA have also been linked to adiposity …”

Section: Discussionmentioning

confidence: 99%

Serum cytokine measurements and biological therapy of psoriasis – Prospects for personalized treatment?

Solberg

Sandvik

et al. 2018

Scand J Immunol

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Psoriasis is an immune-mediated disease where the IL-23/Th17 axis as well as TNF comprise main targets of biological therapy. Immune profiling has so far not been embraced as a clinical tool. We aimed to investigate relationships between individual serum cytokine levels in 40 psoriasis patients before and after receiving biological therapy and Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI). Serum concentration of 25 cytokines was determined by Luminex technology. Mean PASI and DLQI decreased by 71% and 65%, respectively. Increase of IL-2 positively correlated with improvement of PASI and DLQI. Moreover, increase of IL-5, IL-10, IL-12, IL-22 and GM-CSF correlated with treatment effect. Notably, logistic regression revealed four times higher risk of having severe psoriasis when IL-17A increased by 1 pg/mL (OR: 4.06, P < 0.05). Selected serum cytokines might constitute useful biomarkers for monitoring disease activity and optimizing therapeutic strategies in psoriasis patients.

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“…It was recently discovered that IL‐22 is associated with obesity and type 2 diabetes . Variants in the gene encoding IL‐1RA have also been linked to adiposity …”

Section: Discussionmentioning

confidence: 99%

Serum cytokine measurements and biological therapy of psoriasis – Prospects for personalized treatment?

Solberg

Sandvik

et al. 2018

Scand J Immunol

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“…Another study of CLOCK SNPs reported that three SNPs were associated with plasma cytokine levels, especially IL-6, adiponectin, and CCL2/MCP-1 [86]. Separately, variable number tandem repeats (VNTRs), such as 86 bp repeats in IL-1 receptor antagonist (IL-1RA) intron 2 and 70 bp in IL-4 intron 3, were reported to be associated with obesity and adiposity in a Malaysian study [87]. Apolipoprotein ApoA-IV, found on high-density lipoproteins (HDL) cholesterol in serum, as well as in circulation, is known to have anti-inflammatory effects.…”

Section: Circadian Rhythm In Allergymentioning

confidence: 99%

Crosstalk Among Circadian Rhythm, Obesity and Allergy

Orihara

Haraguchi

Shibata

2020

IJMS

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The circadian clock system works not only as a cellular time-keeper but also as a coordinator for almost all physiological functions essential to maintaining human health. Therefore, disruptions or malfunctions of this system can cause many diseases and pre-symptomatic conditions. Indeed, previous studies have indicated that disrupted clock gene expression rhythm is closely related to obesity, and that allergic diseases can be regulated by controlling peripheral clocks in organs and tissues. Moreover, recent studies have found that obesity can lead to immune disorders. Accordingly, in this review, we assess the connection between obesity and allergy from the point of view of the circadian clock system anew and summarize the relationships among the circadian clock system, obesity, and allergy.

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“…With regard to obesity, two previous Asian studies with relatively small sample sizes found no significant association between IL1RA VNTR and BMI in Koreans [ 200 ] and North Indians [ 201 ]. Similarly, our study found no association with BMI value or overall obesity status, but IL1RA II allele VNTR was associated with higher TBF value and higher risk for overall adiposity [ 202 ].…”

Section: Main Textmentioning

confidence: 78%

“…With regard to obesity, there are limited studies on this VNTR, where two studies showed no association [ 215 , 216 ]. Our study showed that this VNTR was associated with overall adiposity status (TBF class), but not with TBF value after adjustment for ethnicity [ 202 ]. A previous study in north Indians also showed that the B2B2 genotype was associated with higher risk for T2D [ 217 ].…”

Section: Main Textmentioning

confidence: 99%

The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

Say

2017

J Physiol Anthropol

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BackgroundDespite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity. This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance—collectively known as metabolic syndrome). Hence, this paper reviews the types of INDELs and VNTRs that have been studied for association with obesity and its related traits and complications.Main body of the abstractThese INDELs and VNTRs could be found in the obesity loci or genes from the earliest GWAS and candidate gene association studies, like FTO, genes in the leptin–proopiomelanocortin pathway, and UCP2/3. Given the important role of the brain serotonergic and dopaminergic reward system in obesity susceptibility, the association of INDELs and VNTRs in these neurotransmitters’ metabolism and transport genes with obesity is also reviewed. Next, the role of INS VNTR in obesity and its related traits is questionable, since recent large-scale studies failed to replicate the earlier positive associations. As obesity results in chronic low-grade inflammation of the adipose tissue, the proinflammatory cytokine gene IL1RA and anti-inflammatory cytokine gene IL4 have VNTRs that are implicated in obesity. A systemic proinflammatory state in combination with activation of the renin–angiotensin system and decreased nitric oxide bioavailability as found in obesity leads to endothelial dysfunction. This explains why VNTR and INDEL in eNOS and ACE, respectively, could be predisposing factors of obesity. Finally, two novel genes, DOCK5 and PER3, which are involved in the regulation of the Akt/MAPK pathway and circadian rhythm, respectively, have VNTRs and INDEL that might be associated with obesity.Short conclusionIn conclusion, INDELs and VNTRs could have important functional consequences in the pathophysiology of obesity, and research on them should be continued to facilitate obesity prediction, prevention, and treatment.

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Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects

Cited by 10 publications

References 41 publications

Serum cytokine measurements and biological therapy of psoriasis – Prospects for personalized treatment?

Serum cytokine measurements and biological therapy of psoriasis – Prospects for personalized treatment?

Crosstalk Among Circadian Rhythm, Obesity and Allergy

The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

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