Interleukin-1 production in acute viral hepatitis.

Müller, Christian; Gödl, I.; Ahmad, Raiz; Wolf, Hermann M.; Mannhalter, Josef W.; Eibl, Martha M.

doi:10.1136/adc.64.2.205

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Different serum cytokine profiles in distinct clinical profiles of hepatitis A have been described [ 1 ]. In contrast with most infectious diseases, acute viral hepatitis is characterized by a lack or only a moderate degree of acute phase reaction, which takes an asymptomatic course, especially in children [ 11 ]. Torre et al reported that serum levels of IL-1a, IL-6, and TNF-α were increased during the acute phase of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Müller et al studied IL-6 and IL-1 levels in patients with hepatitis A in two different studies. He demonstrated normal levels of IL-6 and severely decreased during the first week and gradually increased IL-1 levels during the further course of hepatitis A [ 11 , 15 ]. Fierro et al reported an over expression of TNF-α, IL-1, and IL-6 in children with HAV-induced intermediate liver damage while minor liver damage was characterized by increase of IL-8 and transforming growth factor beta, suggesting that an imbalance in the inflammatory cytokines occurs during the course of hepatitis A [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

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Mean platelet volume in children with hepatitis A

Akın

Sert²,

Arslan³

2016

J Health Popul Nutr

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BackgroundMean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A.MethodsIn this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects.ResultsMPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower. Two weeks after admission, the MPV values showed a significant decrease from 9.47 ± 1.62 to 8.84 ± 1.48 fL in patients with hepatitis A, but these values were still significantly higher than the controls. There was a significant difference in terms of MPV, WBC, AST, and ALT values between the controls and the patient group 2 weeks after admission.ConclusionsThis study is the first to evaluate the MPV levels in children with hepatitis A. MPV values were found to be increased in children hospitalized with hepatitis A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mean platelet volume in children with hepatitis A

Akın

Sert²,

Arslan³

2016

J Health Popul Nutr

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“…Moreover infection with several viruses [including hepatitis A virus (HAV), hepatitis B virus (HBV), human immunodeficiency virus-1 (HIV-1), Epstein Barr virus (EBV) and cytomegalovirus (CMV)] was previously shown to affect IL-1 secretion [1,15,18,22,28]. However, in these studies, the effect of viral infection on IL-1 gene transcription was not studied.…”

Section: Hsv-1 and Interleukin-1 265mentioning

confidence: 93%

Induction of interleukin-1 ? and ? gene transcription in mouse peritoneal exudate cells after intraperitoneal infection with herpes simplex virus-1

Sprecher

Becker

1990

Archives of Virology

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Macrophages have been shown to play a determining role in the immune defense against herpes simplex virus-1 (HIV-1) intraperitoneal infection in the mouse. In the present study, the effect of HSV-1 infection on interleukin-1 alpha and beta gene transcription in peritoneal exudate cells was investigated. HSV-1 infection was found to induce interleukin-1 alpha and beta gene transcription in these cells. Induction of the interleukin-1 beta gene initiated 6 h postinfection (p.i.) and terminated at 48 h p.i. In contrast, interleukin-1 alpha RNA was detectable at high levels at 6h p.i. but not at 24 h p.i. Inactivation of virus prior to infection prevented HSV-1-induced IL-1 gene induction, indicating that only infectious virus is able to stimulate IL-1 gene transcription. These findings are discussed in relation to the role of macrophages in the immunological mechanisms of defense against HSV-1 infection.

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“…Infection by a number of viruses, including hepatitis A virus, hepatitis B virus [1,29], Epstein-Barr virus [38], human immunodeficiency virus-1 [15,25,47], and cytomegalovirus [21], has previously been shown to affect IL-I secretion by peripheral blood monocytes. Recently, Sprecher and Becker [41] reported that HSV-l-infection induced IL-la and IL-I~ gene-transcription in murine peritoneal exudate cells after infection in vivo.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-1 alpha gene-transcription in murine keratinocytes is inhibited by HSV-1 infection

Enk

Sprecher

Becker

1991

Archives of Virology

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The effect of in vitro infection with herpes simplex virus 1 (HSV-1) on the Interleukin-1 (IL-1) activity of murine keratinocytes was investigated. IL-1 alpha mRNA synthesis was measured by the Northern blot technique, and the IL-1 protein production was measured in terms of the ability of dialysed supernatants from cultures of uninfected and HSV-1 infected keratinocytes to enhance mitogen-induced murine thymocyte proliferation. IL-1 alpha mRNA-synthesis in uninfected keratinocytes was detected 24 h and 48 h after isolation of the keratinocytes. IL-1 protein secretion by these keratinocytes was measureable at 18 h and reached a peak of 73 h, whereas intracellular and membrane-bound IL-1 protein production reached a maximum after 25 h. Keratinocytes, which had been cultured in vitro for 18 h, were infected with HSV-1 for 2 h and further cultured for an additional 4 h or 22 h before IL-1 measurements. A marked reduction of IL-1 alpha gene-expression was noted 6 hours after HSV-1-infection of keratinocytes, and nearly total shut-off was detected after infection for 24 h. Reduced gene-expression was paralleled by a reduction in the IL-1 protein secretion from the HSV-1 infected keratinocytes.

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Interleukin-1 production in acute viral hepatitis.

Cited by 10 publications

References 33 publications

Mean platelet volume in children with hepatitis A

Mean platelet volume in children with hepatitis A

Induction of interleukin-1 ? and ? gene transcription in mouse peritoneal exudate cells after intraperitoneal infection with herpes simplex virus-1

Interleukin-1 alpha gene-transcription in murine keratinocytes is inhibited by HSV-1 infection

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