Interleukin-1 Family Expression in Human Breast Cancer: Interleukin-1 Receptor Antagonist

Miller, Lauri J.; Kurtzman, Scott H.; Anderson, Kathleen; Wang, Yanping; Stankus, Marra; Renna, María Sol; Lindquist, R R; Barrows, George H.; Kreutzer, Donald L.

doi:10.3109/07357900009012171

Cited by 73 publications

(55 citation statements)

References 22 publications

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“…In vitro studies have shown that IL-1 can inhibit malignant cell growth by affecting DNA synthesis (Shen et al, 2002). In human BC, IL-1 is involved in local regulation of tumor growth, angiogenesis, proliferation, and tumor attack (Miller et al, 2000;Pantschenko et al, 2003;Singer et al, 2003). IL-1a may also affect the risk of BC by regulating cell proliferation through a Ca 2+ / calmodulin-dependent pathway (Inokuchi et al, 1995), considering that breast calcification is a key risk factor for BC (Tse et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

Huang

Yang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism. The ins/ins (ttca/ttca) genotype was significantly associated with a decreased risk of BC compared with the del/del (-/-) genotype (OR = 0.48, 95% CI = 0.27-0.85). Moreover, the ins (ttca) allele distribution between cases and controls was significantly different from the del (-) allele distribution (OR = 0.74, 95% CI = 0.57-0.96). Thus, the rs3783553 polymorphism is associated with a decreased incidence of breast cancer.

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Section: Discussionmentioning

confidence: 99%

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

Huang

Yang

et al. 2016

Genet. Mol. Res.

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“…IL-1 ra levels correlate directly with the presence of estrogen receptors in breast cancers. Because IL-1, which is induced by TGF-␤ in wounded keratinocytes (59), is also associated with estrogen receptor-negative, poor prognosis cancers (60), the down-regulation of IL-1 ra might be permissive for IL-1 actions.…”

Section: Tgf-␤ Enhances Smad-dependent Transcription and Differentialmentioning

confidence: 99%

Overexpression of HER2 (erbB2) in Human Breast Epithelial Cells Unmasks Transforming Growth Factor β-induced Cell Motility

Ueda¹,

Wang

Dumont

et al. 2004

Journal of Biological Chemistry

150

146

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“…In human breast cancer, an important role of IL-1 and IL-1RA expression was noted in various studies (5 -7). These studies suggest that the IL-1 system is vital in the local control of tumor growth (6), important in regulating ''protumorigenic'' activities within the tumor microenvironment (7), and contributes to angiogenesis, tumor proliferation, and tumor invasion (5).…”

mentioning

confidence: 99%

Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women

Hefler¹,

Grimm²,

Lantzsch

et al. 2005

Clinical Cancer Research

109

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Purpose: Genetic polymorphisms of cytokine-encoding genes are known to predispose to malignant disease. Interleukin (IL)-1 and IL-6 are crucially involved in breast carcinogenesis. Whether polymorphisms of the genes encoding IL-1 (IL1) and IL-6 (IL6) also influence breast cancer risk is unknown. Experimental Design: In the present case-control study, we ascertained three polymorphisms of the IL1gene cluster [À889 C/T polymorphism of the IL1a gene (IL1A), À511C/T polymorphism of the IL1b promoter (IL1B promoter), a polymorphism of IL1b exon 5 (IL1B exon 5)], an 86-bp repeat in intron 2 of the IL1 receptor antagonist gene (IL1RN), and the À174 G/C polymorphism of the IL6 gene (IL6) in 269 patients with breast cancer and 227 healthy controls using PCR and pyrosequencing. Results: Polymorphisms within the IL1 gene cluster and the respective haplotypes were not associated with the presence and the phenotype of breast cancer. The IL6 polymorphism was significantly associated with breast cancer. Odds ratios for women with one or two high-risk alleles versus women homozygous for the low-risk allele were 1.5 (95% confidence interval, 1.04-2.3; P = 0.04) and 2.0 (95% confidence interval, 1.1-3.6; P = 0.02), respectively. No association was ascertained between presence of the IL6 polymorphism and various clinicopathologic variables. Conclusions: Although polymorphisms within the IL1 gene cluster do not seem to influence breast cancer risk or phenotype, presence of the À174C IL6 allele increases the risk of breast cancer in Caucasian women in a dose-dependent fashion.

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Interleukin-1 Family Expression in Human Breast Cancer: Interleukin-1 Receptor Antagonist

Cited by 73 publications

References 22 publications

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

Overexpression of HER2 (erbB2) in Human Breast Epithelial Cells Unmasks Transforming Growth Factor β-induced Cell Motility

Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women

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