1989
DOI: 10.1126/science.2799385
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Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

Abstract: Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1-responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c-jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c-fos. Thus, the two components of the AP-1 facto… Show more

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Cited by 263 publications
(129 citation statements)
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“…Thus, the anticarcinogenic e ect of curcumin may be due to its inhibition of these cellular pathways and suppression of cell growth. Besides cell proliferation, AP-1 and NF-kB are also involved in the cellular reaction to in¯ammatory cytokines such as interleukin-1 and TNF-a (Brenner et al, 1989;Finco and Baldwin, 1995;Muegge et al, 1989), which play important roles in many immune responses. Curcumin's ability to block AP-1 and NF-kB could be a useful tool in controlling in¯ammatory and autoimmune diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the anticarcinogenic e ect of curcumin may be due to its inhibition of these cellular pathways and suppression of cell growth. Besides cell proliferation, AP-1 and NF-kB are also involved in the cellular reaction to in¯ammatory cytokines such as interleukin-1 and TNF-a (Brenner et al, 1989;Finco and Baldwin, 1995;Muegge et al, 1989), which play important roles in many immune responses. Curcumin's ability to block AP-1 and NF-kB could be a useful tool in controlling in¯ammatory and autoimmune diseases.…”
Section: Discussionmentioning
confidence: 99%
“…This cytokine regulates most of the genes by a transcriptional mechanism involving members of the C/EBP family, HNF1, AP1, and NF-B transcription factors (31)(32)(33). However, IL-1 signal transduction pathways in hepatocytes are still unknown.…”
Section: Discussionmentioning
confidence: 99%
“…IL-1β has been shown to mediate the transcriptional activation of IL-2 through AP-1 sites, and the 5′ flanking region of the VEGF gene contains several AP-1 binding sites (Muegge et al, 1989;Tischer et al, 1991). It is therefore possible that IL-1β increases VEGF transcription by activating pathways that lead to AP-1 activation and binding to the VEGF promoter.…”
Section: Discussionmentioning
confidence: 99%