Interleukin 1 Beta (IL1beta) Gene Polymorphisms (SNP-511 and SNP+3953) in Hashimoto’s Thyroiditis among the Polish Population

Łącka, Katarzyna; Paradowska‐Gorycka, Agnieszka; Maciejewski, Adam; Kramer, Lisa A.; Herman, Waldemar A; Łącki, Jan

doi:10.1055/s-0034-1376967

Cited by 15 publications

(5 citation statements)

References 11 publications

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“…The findings are in agreement with the study of Zaaber et al, suggesting a significant relation between IL-1β rs1143634 SNP and GD and HT in the Tunisian population [27]. Lacka et al and Rashad et al also found a significant relationship between IL-1β rs1143634 SNP and HT in a Polish and Egyptian population, respectively [36,37]. In contrast, Chen et al found no association between IL-1β rs1143634 SNP and GD risk in Taiwan [38], while Liu et al found a positive relationship between the C allele of rs1143634 and GD risk [39].…”

Section: Discussionsupporting

confidence: 92%

Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Heidari

Salimi

Rokni

et al. 2021

BioMed Research International

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Background. Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) are autoimmune diseases of the thyroid gland in which genetic predisposition plays a major role in their development. Currently, the role of NLRP3 inflammasome and COX-2 has been documented in many autoimmune diseases. The purpose of the study is to delineate the impact of IL-1β (rs1143634), NLRP3 (rs3806265), and COX-2 (rs2745557) gene polymorphisms in the development of GD and HT. Methods. A total of 256 newly diagnosed patients with autoimmune thyroid disease (135 patients with HT and 121 GD patients) as case groups and 145 controls were included in the study. Results. Recessive and overdominant models showed a significant association between IL-1β rs1143634 SNP and HT development risk. The frequency of TT genotype and T allele of IL-1β rs1143634 SNP in the control group was significantly higher than the GD group. There was no significant association between NLRP3 rs3806265 polymorphism and HT and GD development. The frequency of GA genotype of COX-2 (rs2745557) in the control group was significantly higher than that in the HT group. There was no significant association between COX-2 rs2745557 genotypic and allelic distribution and GD development risk. The results revealed a significant relationship between some clinical features of HT and GD groups and SNPs studied. Conclusion. The results manifest the significant impact of IL-1β rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1β rs1143634 SNP on GD occurrence risk. Furthermore, a significant relationship was observed between some clinical features of HT and GD groups and studied SNPs.

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Section: Discussionsupporting

confidence: 92%

Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Heidari

Salimi

Rokni

et al. 2021

BioMed Research International

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“…We did not assess polymorphisms, but the higher concentrations of selected cytokines may indicate that the genetic factors responsible for their production are of great importance in Hashimoto's disease. This has also been suggested by other Polish researchers [14]. IL-1β is released by peripheral blood monocytes, stimulates T lymphocytes to synthesize other proinflammatory cytokines, and affects the proliferation and differentiation of B lymphocytes.…”

Section: Discussionsupporting

confidence: 71%

Level of selected pro-inflammatory markers in middle-aged women with Hashimoto’s disease

Szczepanik¹,

Graczyk²,

Domaszewska³

2020

jhi

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Introduction: Hashimoto's disease is an autoimmune disease in which the body produces antibodies against its own tissues, in this case against thyrocytes. Autoimmune diseases are associated with impaired immune tolerance. The aim of this study was to analyse selected pro-inflammatory markers in women with Hashimoto's (HT) autoimmune thyroiditis compared to a group of healthy women. Material and methods: In this research study 41 women with HT were compared with 30 healthy women. The content of immunological markers was assessed in blood serum by enzyme-linked ELISA methods. Cytokine IL-1ß, IL-6, and TNF-α were assessed. Results: The concentration of IL-1β for women with HT was 3.1 (1.8-4.9) pg/ml, and for healthy women 1.0 (0.1-1.9) pg/ml. The concentration of IL-6 for women with HT was 12.1 (6.7-19.4) pg/ml, and for healthy women 3.8 (2.5-6.7) pg/ml. TNF-α concentration was higher for people with HT, at 3.4 (2.0-4.4) pg/ml, compared to healthy women, who had a level of 2.2 (1.2-3.4) pg/ml), but without significant statistical differences. Conclusions: In HT we observe an increased immune response associated with an elevated concentration of pro-inflammatory cytokines.

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“…Other parameters determined in this study were IL-1β [ 48 , 49 , 50 ] and IL-17 [ 42 , 51 , 52 ], which are associated with the pathogenesis of HT. In the study of Phenekos et al, the level of IL-1β in the serum of patients with HT at different stages of disease (TSH > 8 μIU/mL; some participants were treated with L-T 4 for up to 18 months) was significantly lower than in the group of healthy subjects (2.52 ± 0.14 vs. 3.6 ± 0.20 pg/mL) [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis

et al. 2022

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The impact of selenium on the course of Hashimoto’s thyroiditis (HT) was mainly assessed by monitoring the titer of antithyroid autoantibodies in most of the studies conducted hitherto. On the other hand, the imbalance in activity of T cells such as Th1, Th2, Th17, and Treg may be relevant in the pathogenesis of this disease. Hence, the assessment of changes in the secretion of cytokines by these cells during selenium supplementation in patients with HT seems to be an important issue and was the main goal of this study. A further aim was to search for correlations among these cytokines, as well as markers of thyroid function, selenium/iodine status in the body, and other biochemical parameters. The group of 29 women with newly diagnosed Hashimoto’s thyroiditis was supplemented with selenium in a dose of 100 µg/day for 6 months. Immunological parameters: interferon γ, tumor necrosis factor α, chemokine CXCL10, interleukin 4, interleukin 1β, interleukin 17, transforming growth factor β, and C-reactive protein, as well as selenium status parameters were determined in serum twice, i.e., before and after supplementation. Selenium supplementation was associated with a change in the production of two cytokines: interferon γ and interleukin 1β, for which a decrease and an increase in concentration were observed, respectively. The partial least squares (PLS) model revealed the presence of many relevant correlations among analyzed parameters. The stage of HT development, degree of thyroid dysfunction, and selenium supplementation of diet are interdependent factors which shape the profile of some cytokines secreted by cells participating in the autoimmunity process.

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Interleukin 1 Beta (IL1beta) Gene Polymorphisms (SNP-511 and SNP+3953) in Hashimoto’s Thyroiditis among the Polish Population

Abstract: An association between the SNPs of the IL1 beta and susceptibility to Hashimoto's thyroiditis among the group of Caucasian-Polish population studied was found.

Cited by 15 publications

References 11 publications

Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Level of selected pro-inflammatory markers in middle-aged women with Hashimoto’s disease

Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis

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