Interleukin-1 Beta and Tumor Necrosis Factor-Alpha in Normal/Infertile Men

Papadimas, J.; Goulis, Dimitrios G.; Sotiriades, A; Daniilidis, M.; Fleva, Alexandra; Bontis, J.; Tourkantonis, A.

doi:10.1080/014850102317267418

Cited by 20 publications

(17 citation statements)

References 17 publications

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“…The decrease of cholesterol together with an increase of in ammatory markers may synergically impact the reproductive function leading to male infertility. The same negative correlation between cholesterol and IL-6 was also observed in azoospermic patients; in this group, no particular other correlation was found con rming as cytokine concentrations are not always related to sperm parameters [42][43][44].…”

Section: Discussionsupporting

confidence: 77%

Pro-Inflammatory Cytokines and MicroRNAs in Male Infertility

Attia

Finocchi

Orciani

et al. 2021

Preprint

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Background: Male infertility is a problem that affects 10-15% of men of reproductive age. In particular, gametogenesis is a complex process in which inflammation may play a central role through the secretion of cytokines and the expression of microRNAs. We assessed the potential role of proinflammatory cytokines (TNF-α, IL-6 and IL-1α) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls furthermore, evaluating their correlation with seminal and biochemical parameters.Methods and Results: Expression of cytokines and microRNAs were analyzed by ELISA and q-PCR. Our data show that IL-1α was significantly increased in the azoospermic group compared to controls, TNF-α mRNA was more expressed in the oligozoospermic group than controls. There were no significant differences in miRNAs expression among the three groups. The correlations between sperm parameters and inflammatory markers were evaluated, however no significant difference was highlighted.Conclusions: The determination of each inflammatory marker separately in the seminal plasma of subfertile men, despite some significant differences, does not have a diagnostic value in male infertility even if an assay of selective pro-inflammatory cytokines and microRNAs in the semen may improve the diagnosis of male infertility.

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Section: Discussionsupporting

confidence: 77%

Pro-Inflammatory Cytokines and MicroRNAs in Male Infertility

Attia

Finocchi

Orciani

et al. 2021

Preprint

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“…Different studies reported that cytokines (IL-1α, IL-1β, Il-6, IL-8, IL-12, and TNF-α) are involved in the regulation of spermatogenesis, semen quality, and male reproductive tract pathological conditions (Eggert-Kruse et al, 2001; Papadimas et al, 2002; Sanocka et al, 2003). However, the nature, origin, and role of different cytokines in the male reproductive tract are not yet clearly understood (Fraczek and Kurpisz, 2015).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice

Farcas

Kisin

Menas

et al. 2016

Journal of Toxicology and Environmental Health, Part A

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Over the past several years there has been an increased number of applications of cellulosic materials in many sectors, including the food industry, cosmetics, and pharmaceuticals. However, to date, there are few studies investigating the potential adverse effects of cellulose nanocrystals (CNC). The objective of this study was to determine long-term outcomes on the male reproductive system of mice upon repeated pharyngeal aspiration exposure to CNC. To achieve this, cauda epididymal sperm samples were analyzed for sperm concentration, motility, morphological abnormalities, and DNA damage. Testicular and epididymal oxidative damage was evaluated, as well as histopathology examination of testes. In addition, changes in levels of testosterone in testes and serum and of luteinizing hormone (LH) in serum were determined. Three months after the last administration, CNC exposure significantly altered sperm concentration, motility, cell morphology, and sperm DNA integrity. These parameters correlated with elevated proinflammatory cytokines levels and myeloperoxidase (MPO) activity in testes, as well as oxidative stress in both testes and epididymis. Exposure to CNC also produced damage to testicular structure, as evidenced by presence of interstitial edema, frequent dystrophic seminiferous tubules with arrested spermatogenesis and degenerating spermatocytes, and imbalance in levels of testosterone and LH. Taken together, these results demonstrate that pulmonary exposure to CNC induces sustained adverse effects in spermatocytes/spermatozoa, suggesting male reproductive toxicity.

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“…The list of published articles indicating direct connections between various cytokine levels in seminal fluid and sperm quality is long [81,162]. Most investigators have suggested that seminal cytokines are mostly associated with the presence of leukocytes [163][164][165]. Elevated cytokine presence in the semen has been also attributed to pathogens [135,162,166].…”

Section: Role Of the Immune/autoimmune Reactionsmentioning

confidence: 99%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

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Interleukin-1 Beta and Tumor Necrosis Factor-Alpha in Normal/Infertile Men

Cited by 20 publications

References 17 publications

Pro-Inflammatory Cytokines and MicroRNAs in Male Infertility

Pro-Inflammatory Cytokines and MicroRNAs in Male Infertility

Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

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