Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice

Namekata, Kazuhiko; Harada, Chikako; Guo, Xiaoli; Kikushima, Kenji; Kimura, Atsuko; Fuse, Nobuo; Mitamura, Yoshinori; Kohyama, Kuniko; Matsumoto, Yoh; Tanaka, Kohichi; Harada, Takayuki

doi:10.1016/j.neulet.2009.09.029

Cited by 29 publications

(36 citation statements)

References 16 publications

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“…Previous reports have shown that IL-1␤ develops neurotoxic properties in the brain. 5,13,32 However, in the retina IL-1␤ was shown to inhibit ganglion cell death, 6 and IL-1␤ substitution saved photoreceptors in light-induced models 7 and genetic retinal degeneration. 8 Here, we show that IL-1␤ is significantly induced in the light-induced model in albino rats ( Figure 4D) and in albino mice ( Figure 5B).…”

Section: Discussionmentioning

confidence: 99%

“…1 IL-1␤ is a potent inflammatory mediator with chemotactic 2 and angiogenic 3,4 properties. It is a neurotoxic mediator in ischemic brain injury 5 but can attenuate glutamate neurotoxicity in the retina 6 and protect against light-induced or hereditary photoreceptor degeneration. 7,8 Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly persons in industrialized countries.…”

mentioning

confidence: 99%

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Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration

Lavalette

Raoul

Houssier

et al. 2011

The American Journal of Pathology

120

106

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration

Lavalette

Raoul

Houssier

et al. 2011

The American Journal of Pathology

120

106

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“…These results suggest that integrity of GLT-1 may be a prerequisite for the maintenance of glutamate homeostasis in the retina undergoing glaucoma [67]. Sullivan et al (2006) [68] reported the expressional changes of the splice variant of GLT-1 (GLT-1c) in the glaucoma eyes. In normal eyes of humans and rats, GLT-1c is expressed only in photoreceptors.…”

Section: B Glt-1mentioning

confidence: 85%

Excitotoxicity and Glaucoma

Ishikawa¹,

Yoshitomi²,

Izumi³

2014

Ophthalmology - Current Clinical and Research Updates

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“…Recent advances in the study of glaucoma or RGCs reveal that cytokines are a possible factor in the pathogenesis of glaucoma and may regulate RGC survival or death [26,27] . Abundant laboratory evidence indicates that the inflammatory cytokines, including IL-1, IL-6, and TNF-α, have either protective or adverse effects on glaucoma [26,27] .…”

Section: Discussionmentioning

confidence: 99%

“…Abundant laboratory evidence indicates that the inflammatory cytokines, including IL-1, IL-6, and TNF-α, have either protective or adverse effects on glaucoma [26,27] . IL-6 is known to modulate neuronal survival in the central nervous system [28,29] .…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Interleukin-6 (-174) Locus Polymorphism and Serum IL-6 Levels with the Severity of Normal Tension Glaucoma

Wang

Liang²,

Feng³

et al. 2017

Ophthalmic Res

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Purpose: In normal tension glaucoma (NTG), factors other than elevated intraocular pressure are likely to have a role in the pathogenesis of optic neuropathy. Recent studies of glaucoma or retinal ganglion cells (RGCs) reveal that the cytokine interleukin-6 (IL-6) is linked to the pathogenesis of glaucoma and may regulate RGC survival or death. The IL-6 (-174) G allele has also been shown to increase the IL-6 protein. We hypothesized that the IL-6 (-174) polymorphism may be a predisposing genetic factor affecting the severity of glaucoma. The aim of the present study was to evaluate the IL-6 polymorphism and serum IL-6 levels as a potential risk factor related to the severity of NTG. Methods: A total of 256 subjects with NTG in the Chinese population were enrolled. The patients were genotyped for the IL-6 (-174) C/G polymorphism. Genomic DNA was amplified by a polymerase chain reaction, followed by the enzymatic restriction fragment length polymorphism technique. Serum IL-6 levels were measured by ELISA. Patient age at diagnosis, cup/disc (C/D) ratio, rim area (RA), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) were analyzed. The associations between genotypes of IL-6 (-174) C/G and the clinical parameters were calculated using a logistic regression. Results: The IL-6 (-174) GC genotype in NTG patients was significantly associated with a smaller C/D ratio (p = 0.04), larger RA (p = 0.04), and thicker RNFL (p = 0.05) compared with IL-6 (-174) GG patients. The allele frequency of IL-6 (-174) C was significantly higher in the NTG patients at an early-moderate stage than at an advanced stage according to the C/D ratio (OR 0.55; 95% CI 0.31-0.99). Pattern standard deviation of VF was borderline lower in IL-6 (-174) GC patients (p = 0.06), and serum IL-6 levels were borderline higher in advanced stages than in early-moderate stages (7.66 ± 3.22 vs. 4.46 ± 3.83 pg/mL; p = 0.06). Conclusion: The IL-6 (-174) GC genotype is associated with a smaller C/D ratio, larger RA, and thicker RNFL compared with IL-6 (-174) GG in NTG patients. We found that the IL-6 (-174) G/C polymorphism and serum IL-6 levels may be associated with the severity of NTG.

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Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice

Cited by 29 publications

References 16 publications

Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration

Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration

Excitotoxicity and Glaucoma

Analysis of the Interleukin-6 (-174) Locus Polymorphism and Serum IL-6 Levels with the Severity of Normal Tension Glaucoma

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