Interleukin-1 and Interleukin-6 Polymorphisms Might Influence Predisposition to Hemorrhagic Cerebral Vascular Diseases: A Meta-Analysis

Abstract

<b><i>Background:</i></b> Interleukin-1 (<i>IL-1</i>) and <i>IL-6</i> polymorphisms might influence predisposition to hemorrhagic cerebral vascular diseases, but the results of already published studies regarding relationship between <i>IL-1/IL-6</i> polymorphisms and hemorrhagic cerebral vascular diseases were still controversial and ambiguous. <b><i>Objectives:</i></b> The authors designed this meta-analysis to more precisely estimate the relationship between <i>IL-1/IL-6</i> polymorphisms and hemorrhagic cerebral vascular diseases by pooling the results of already published related studies. <b><i>Methods:</i></b> The authors searched PubMed, EMBASE, Web of Science, and CNKI for already published studies. Eighteen already published studies were pooled analyzed in this meta-analysis. <b><i>Results:</i></b> The pooled meta-analyses’ results showed that distributions of <i>IL-1A</i> rs1800587, <i>IL-1B</i> rs16944, and <i>IL-6</i> rs1800796 polymorphisms among patients and controls differed significantly. Moreover, distribution of the <i>IL-6</i> rs1800795 polymorphism among patients and controls from Asians also differed significantly. Further analyses showed similar findings for <i>IL-1A</i> rs1800587, <i>IL-1B</i> rs16944, and <i>IL-6</i> rs1800796 polymorphisms in aneurysmal subarachnoid hemorrhage (aSAH) subgroup. <b><i>Conclusions:</i></b> This meta-analysis suggested that <i>IL-1A</i> rs1800587, <i>IL-1B</i> rs16944, and <i>IL-6</i> rs1800796 polymorphisms might influence susceptibility to hemorrhagic cerebral vascular diseases, especially for aSAH. Moreover, <i>IL-6</i> rs1800795 might influence susceptibility to hemorrhagic cerebral vascular diseases in Asians.