Interleukin-1 and interleukin-2 activity in chronic hepatitis B virus infection

Anastassakos, Ch.; Alexander, Graeme; Wolstencroft, R. A.; Avery, J; Portmann, Bernard; Panayi, G. S.; Dumonde, D. C.; Eddleston, A. L. W. F.; Williams, Roger

doi:10.1016/0016-5085(88)90559-8

Cited by 73 publications

(22 citation statements)

References 14 publications

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“…On the other hand, IL-1 also modulates regeneration of connective tissue by stimu lating fibroblast proliferation [24], Although the effects of IL-1 on collagen synthesis by fibroblasts remain controversial [25], it is thought to induce proliferation and collagen synthesis of fibroblasts [26]. Our results, to gether with a report that IL-1 production by peripheral blood monocytes was increased in patients with chronic hepatitis [27], suggest that IL-1 may be involved in hepatic fibro sis. However, the degree to which the bal ance of collagen metabolism is regulated by IL-1 remains to be further evaluated.…”

Section: Discussionsupporting

confidence: 58%

Effects of Various Cytokines on Collagen Synthesis by Normal Rat Hepatocytes in Primary Cultures and Fibroblasts

Kakumu¹,

Yoshioka²,

Arao³

et al. 1989

Digestion

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Collagen formation is an important function of liver parenchymal and nonparenchymal cells that may be relevant to the pathogenesis of hepatic fibrosis. In the present study, the effect of various kinds of cytokines and prednisolone on collagen synthesis by hepatocytes obtained from perfused rat livers and confluent human skin fibroblasts were investigated. The cells were cultured in serum-free medium for 24 h with [³H]proline and various additives. The amounts of collagen and noncollagen protein synthesis were calculated from the incorporation of [³H]proline into collagen-sensitive and collagen-resistant proteins. The additions of interleukin 1α, interleukin 1β and transforming growth factor α enhanced both collagen and noncollagen protein synthesis by hepatocytes as well as by fibroblasts. Transforming growth factor β also increased both collagen and noncollagen protein synthesis by fibroblasts while it selectively inhibited collagen synthesis by hepatocytes. Interferon preparations and prednisolone showed a selective suppression of collagen synthesis by both cells, indicating that these additives did not affect either cell viability or proliferation during the observed period. These results suggest that collagen synthesis by liver parenchymal cells is either positively or negatively modulated by various kinds of cytokines and hormone.

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Section: Discussionsupporting

confidence: 58%

Effects of Various Cytokines on Collagen Synthesis by Normal Rat Hepatocytes in Primary Cultures and Fibroblasts

Kakumu¹,

Yoshioka²,

Arao³

et al. 1989

Digestion

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“…Investigations carried out with IL-2 report decreases in the levels of its production in patients with chronic HBV infections (3).…”

Section: Discussionmentioning

confidence: 99%

Concentrations of Cytokines, Soluble Interleukin-2 Receptor, and Soluble CD30 in Sera of Patients with Hepatitis B Virus Infection during Acute and Convalescent Phases

Castillo

Romero

Estévez

et al. 2002

Clin Vaccine Immunol

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“…Murine IL-1 a and IL-1 f3 cDNA were cloned and were shown to detect 2.1 and 1.4 kb RNA species, respectively, by the Northern blot technique [14,20]. Both species of IL-1 share the same range of biological activities I-8, 9, 35] and bind to the same 80 kDa receptor [1][2][3][4][5][6][7][8][9][10]. Recent in situ hybridization studies, confirming previous reports, have shown that IL-1 gene transcription in peripheral leukocytes is confined to macrophages or monocytes [1][2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Induction of interleukin-1 ? and ? gene transcription in mouse peritoneal exudate cells after intraperitoneal infection with herpes simplex virus-1

Sprecher

Becker

1990

Archives of Virology

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Macrophages have been shown to play a determining role in the immune defense against herpes simplex virus-1 (HIV-1) intraperitoneal infection in the mouse. In the present study, the effect of HSV-1 infection on interleukin-1 alpha and beta gene transcription in peritoneal exudate cells was investigated. HSV-1 infection was found to induce interleukin-1 alpha and beta gene transcription in these cells. Induction of the interleukin-1 beta gene initiated 6 h postinfection (p.i.) and terminated at 48 h p.i. In contrast, interleukin-1 alpha RNA was detectable at high levels at 6h p.i. but not at 24 h p.i. Inactivation of virus prior to infection prevented HSV-1-induced IL-1 gene induction, indicating that only infectious virus is able to stimulate IL-1 gene transcription. These findings are discussed in relation to the role of macrophages in the immunological mechanisms of defense against HSV-1 infection.

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Interleukin-1 and interleukin-2 activity in chronic hepatitis B virus infection

Cited by 73 publications

References 14 publications

Effects of Various Cytokines on Collagen Synthesis by Normal Rat Hepatocytes in Primary Cultures and Fibroblasts

Effects of Various Cytokines on Collagen Synthesis by Normal Rat Hepatocytes in Primary Cultures and Fibroblasts

Concentrations of Cytokines, Soluble Interleukin-2 Receptor, and Soluble CD30 in Sera of Patients with Hepatitis B Virus Infection during Acute and Convalescent Phases

Induction of interleukin-1 ? and ? gene transcription in mouse peritoneal exudate cells after intraperitoneal infection with herpes simplex virus-1

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