Interleukin‐1 and IL‐1 receptor antagonist in gingival crevicular fluid

Rawlinson, Āndrew; Dalati, Mohammed Hani Nouri; Rahman, Shamim; Walsh, T. F.; Fairclough, Angela L.

doi:10.1034/j.1600-051x.2000.027010738.x

Cited by 70 publications

(70 citation statements)

References 16 publications

(39 reference statements)

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“…In this study IL-1β and TNF-α were detected in all GCF samples from periodontally healthy and periodontitis sites, which is in agreement with the findings of some authors [47]. However, few investigators have reported that IL-1β was not found in healthy sites, but only in periodontally diseased sites [48,49].…”

Section: Discussionsupporting

confidence: 81%

A Study to Evaluate the Relationship between Il-1β and Tnf-Α Levels In Gcf in Non- Smoker, Previous or Current Smoker Female Patients with Chronic Periodontitis

Gokhale¹

2014

Dentistry

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Section: Discussionsupporting

confidence: 81%

A Study to Evaluate the Relationship between Il-1β and Tnf-Α Levels In Gcf in Non- Smoker, Previous or Current Smoker Female Patients with Chronic Periodontitis

Gokhale¹

2014

Dentistry

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“…Earlier studies comparing simultaneously periodontitis and peri-implantitis for clinical signs and levels of IL-1β and E2 (PGE2) could not be found. In line with our results for periodontitis patients higher amounts of IL-1β and E2 (PGE) were reported [34][35][36][37][38]. For peri-implantitis patients another study found higher levels of IL-1β modulating attachment loss in implants [39].…”

Section: Periodontitis and Peri-implantitissupporting

confidence: 82%

A Comparison Of Il-1β, E2 (Pge2), Pai-2 and Tnf-Α Levels in Gingival Crevicular Fluid (Gcf) and Peri-Implant Crevicular Fluid (Picf) from Groups of Patients with Healthy Teeth, Healthy Implants, Periodontitis and Peri-Implantitis

Ketabi¹,

Friese²,

Weber³

2017

Dentistry

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Objectives: The aim of this study was to analyse simultaneously four markers in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) from 41 patients in four different groups over a period of six months in order to establish profiles indicating quantitative ratio and potential correlations. Material and Methods:We compared levels of interleukin-1 beta (IL-1ß), prostaglandin E2 (PGE2), specific plasminogen activator inhibitor 2 (PAI-2) and tumor necrosis factor-alpha (TNF-α) in GCF and PICF from four groups of patients: healthy teeth (n=10), healthy implants (n=10), periodontitis (n=11) and peri-implantitis (n=10). Clinical parameters including bacterial flora were quantified by PCR-analysis. The concentration in GCF/PICF of IL-1β, PAI-2, E2 (PGE2) was determined by ELISA, TNF-α by Western blot analysis.Results: Healthy teeth showed significantly higher levels of IL-1β than healthy implants. The mean level of E2 (PGE2) for healthy teeth was twice as high as for healthy implants. Periodontitis and peri-implantitis sites showed highly increased secretion of IL-1ß and E2 (PGE2) resulting in significantly higher levels of IL-1ß in periodontits than in peri-implantitis. Highest TNF-α levels showed in the peri-implantitis group, lowest in healthy teeth. Lowest concentrations of PAI-2 appeared in peri-implantitis, highest in healthy implants. Conclusions:Within the limits of the study it could be hypothesized that the significantly higher levels of IL-1ß and E2 (PGE2) for healthy teeth than for healthy implants could in part be due to the lack of periodontal ligament cells around implants. Another possible explanation could be the anti-inflammatory property of titanium surfaces of implants.

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“…In this study, IL-1β was detected in the GCF of the studied sites of the subjects, as has also been reported by Preiss and Meyle (24), and Rawlison et al (25). By contrast, Suwatanapongched et al (26) and Wilton et al (27) failed to detect IL-1β in GCF at healthy sites.…”

Section: Discussionsupporting

confidence: 42%

Interleukin-1 gene polymorphisms and periodontal status in a Spanish population

et al. 2012

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Abstract. The aim of this study was to investigate the possible association between interleukin (IL)-1A (+4845) and/or IL-1B (+3954) gene polymorphisms and the onset and progression of chronic periodontal disease (PD), an issue that remains controversial. The relationship between IL-1β concentration in the gingival crevicular fluid (GCF) and disease activity was also evaluated. The study was performed on 25 individuals with no gingivitis or PD and on 25 subjects with active chronic PD. Two samples of GCF were obtained from each subject and IL-1β was determined by enzyme-linked immunoabsorbent assay. Blood samples (10 ml) were drawn from each subject to detect polymorphisms in IL-1A (+4845) and IL-1B (+3954) by polymerase chain reaction. Mean GCF IL-1β concentrations were higher in patients with active chronic PD compared to the control group. No significant association was found in either group between GCF IL-1β concentration and the presence of polymorphisms in IL-1A (+4845), IL-1B (+3954) or both genotypes. No significant difference was found in either group with regard to the presence of polymorphisms in IL-1A (+4845), IL-1B (+3954) or both genotypes (p=0.556). The concentration of IL-1β in GCF was almost 2-fold higher in patients with chronic PD than in the healthy individuals. The presence of polymorphisms in IL-1A (+4845) and/or IL-1B (+3954) genotypes is not associated with IL-1β overproduction in GCF and is not a risk factor for chronic PD. IL-1β is considered a suitable marker of the severity and progression of chronic PD. The presence of IL-1A (+4845) and/or IL-1B +3954 gene polymorphisms does not appear to be a risk factor for chronic PD. Therefore, the IL-1A (+4845) and/or IL-1B +3954 gene polymorphisms cannot be considered genetic markers of chronic PD. Moreover, these polymorphisms do not indicate an overproduction of IL-1β in GCF.

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Interleukin‐1 and IL‐1 receptor antagonist in gingival crevicular fluid

Abstract: The results suggest a strong relationship between the severity of adult periodontitis and the increasing GCF levels of IL-1beta and decreasing levels of IL-1ra.

Cited by 70 publications

References 16 publications

A Study to Evaluate the Relationship between Il-1β and Tnf-Α Levels In Gcf in Non- Smoker, Previous or Current Smoker Female Patients with Chronic Periodontitis

A Study to Evaluate the Relationship between Il-1β and Tnf-Α Levels In Gcf in Non- Smoker, Previous or Current Smoker Female Patients with Chronic Periodontitis

A Comparison Of Il-1β, E2 (Pge2), Pai-2 and Tnf-Α Levels in Gingival Crevicular Fluid (Gcf) and Peri-Implant Crevicular Fluid (Picf) from Groups of Patients with Healthy Teeth, Healthy Implants, Periodontitis and Peri-Implantitis

Interleukin-1 gene polymorphisms and periodontal status in a Spanish population

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