Interlaboratory validation of an environmental monitoring method for trace analysis of endocrine disrupting compounds

Mansilha, Catarina; Rocha, Sónia; Gameiro, Paula; Pinho, C.; Ferreira, Isabel M. P. L. V. O.; Silva, Poliana; Domingues, Valentina F.

doi:10.1039/c2ay25450f

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…In 2011, the European Union banned the use of bisphenol-A (BPA) for the production of polycarbonate (PC) baby bottles (European Union 2011a) due to the wide variety of possible toxic effects of this substance (Vandenberg et al 2012;Singh & Li 2012;Yang et al 2013;Vandenberg et al 2013;Mansilha et al 2013). Since then, a wide variety of alternative materials has entered the market.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the migration of chemicals from baby bottles under standardised and duration testing conditions

Onghena

Hoeck

Negreira

et al. 2016

Food Additives & Contaminants: Part A

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After the prohibition of bisphenol-A-containing polycarbonate baby bottles in the European Union (EU), alternative materials, such as polypropylene, polyethersulphone, Tritan™ copolyester, etc., have appeared on the market. Based on an initial screening and in vitro toxicity assessment, the most toxic migrating compounds were selected to be monitored and quantified using validated GC- and LC-QqQ-MS methods. The effect of several 'real-life-use conditions', such as microwave, sterilisation and dishwasher, on the migration of different contaminants was evaluated by means of duration tests. These results were compared with a reference treatment (filling five times with pre-heated simulant at 40°C) and with the legal EU 'repetitive-use conditions' (three migrations, 2 h at 70°C). Analysis of the third migration step of the EU repetitive-use conditions (which has to comply with the EU legislative migration limits) showed that several non-authorised compounds were observed in some baby bottles exceeding 10 µg kg(-1). However, all authorised compounds were detected well below their respective specific migration limits (SMLs). The reference experiment confirmed the migration of some of the compounds previously detected in the EU repetitive-use experiment, though at lower concentrations. Analysis of extracts from the microwave and dishwasher experiments showed a reduction in the migration during the duration tests. In general, the concentrations found were low and comparable with the reference experiment. Similar observations were made for the two sterilisation types: steam and cooking sterilisation. However, steam sterilisation seems to be more recommended for daily use of baby bottles, since it resulted in a lower release of substances afterwards. Repeated use of baby bottles under 'real-life' conditions showed no increase in the migration of investigated compounds and, after some time, the migration of these compounds even became negligible.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the migration of chemicals from baby bottles under standardised and duration testing conditions

Onghena

Hoeck

Negreira

et al. 2016

Food Additives & Contaminants: Part A

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“…Media and amplitude control charts of BPA-d 16 , used for process evaluation through recovery studies, showed no relevant tendency, so no procedural review was necessary (Mansilha et al 2012). Table 3 summarizes the results of the high temperature migration tests showing, unequivocally, that BPA migration from PC containers is higher when compared to other plastic materials.…”

Section: Analytical Methods Validationmentioning

confidence: 99%

“…After elution, the extracts were evaporated to dryness, reconstituted within ethyl acetate, and derivatized using MSTFA (Mansilha et al 2012;Viñas et al 2010).…”

Section: Migration Studiesmentioning

confidence: 99%

“…GC was directly interfaced to a Shimadzu QP 2010 quadrupole mass spectrometer with an interface temperature of 250°C and ionization by 70 eV electron impact. The transfer line was set at 275°C and the source at 200°C (Mansilha et al 2012).…”

Section: Migration Studiesmentioning

confidence: 99%

“…The first one was to test several plastic containers used to feed children, such as baby bottles, an infant feeding cup, and some disposable and microwave-reheatable containers, since it is a household practice to store and freeze homemade baby food, as soups and purees, in little plastic boxes. Migration experiments were done under defined time and temperature conditions, as it was intended to simulate routine applications (boiling, washing, and reuse), using a gas chromatography-mass spectrometry (GC-MS) method that was developed and validated according to international conventions to provide an accurate quantification of very low levels of BPA (Mansilha et al 2010(Mansilha et al , 2012. The other goal of this study was to assess the impact of BPA on the crustacean D. magna performing preliminary acute and chronic tests according to OECD (2004OECD ( , 2012, and then investigating the impact of direct exposure on reproductive endpoints of daphnids bred in the plastic containers.…”

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confidence: 99%

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Bisphenol A migration from plastic materials: direct insight of ecotoxicity in Daphnia magna

Mansilha

Silva

Rocha

et al. 2013

Environ Sci Pollut Res

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Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) whose migration from food packaging is recognized worldwide. However, the real overall food contamination and related consequences are yet largely unknown. Among humans, children's exposure to BPA has been emphasized because of the immaturity of their biological systems. The main aim of this study was to assess the reproductive impact of BPA leached from commercially available plastic containers used or related to child nutrition, performing ecotoxicological tests using the biomonitoring species Daphnia magna. Acute and chronic tests, as well as single and multigenerational tests were done. Migration of BPA from several baby bottles and other plastic containers evaluated by GC-MS indicated that a broader range of foodstuff may be contaminated when packed in plastics. Ecotoxicological test results performed using defined concentrations of BPA were in agreement with literature, although a precocious maturity of daphnids was detected at 3.0 mg/L. Curiously, an increased reproductive output (neonates per female) was observed when daphnids were bred in the polycarbonate (PC) containers (145.1±4.3 % to 264.7±3.8 %), both in single as in multigenerational tests, in comparison with the negative control group (100.3±1.6 %). A strong correlated dose-dependent ecotoxicological effect was observed, providing evidence that BPA leached from plastic food packaging materials act as functional estrogen in vivo at very low concentrations. In contrast, neonate production by daphnids cultured in polypropylene and non-PC bottles was slightly but not significantly enhanced (92.5±2.0 % to 118.8±1.8 %). Multigenerational tests also revealed magnification of the adverse effects, not only on fecundity but also on mortality, which represents a worrying trend for organisms that are chronically exposed to xenoestrogens for many generations. Two plausible explanations for the observed results could be given: a non-monotonic dose-response relationship or a mixture toxicity effect.

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New Trends in the Analysis of Endocrine Disrupting Compounds in Environmental Samples

Salgueiro‐González

Muniategui-Lorenzo

López-Mahı́a

et al. 2017

Encyclopedia of Analytical Chemistry

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The main aim of this article is to provide an overview of the evolution and trends in the determination of endocrine disrupting compounds (EDCs) in environmental matrices, such as water, sediment, and biota samples. These chemical substances are capable of altering the hormonal system of humans and wildlife at low concentrations, and therefore, continuous investigations based on their occurrence, distribution, and impact are needed to preserve the environment and protect public safety. In order to highlight the gradual change related to the strategies used for EDC determination observed in the past years, this article is divided into four sections: firstly, a brief introduction about the remarkable and emerging EDCs and also the corresponding environmental legislation is included. Then, the state of the determination of EDCs in the environment and the analytical methodologies employed for the analysis of environmental matrices are discussed, with special mention to the new trends in analytical techniques. Finally, future trends required to obtain more data about this topic and control EDCs pollution in the environment are also commented.

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Interlaboratory validation of an environmental monitoring method for trace analysis of endocrine disrupting compounds

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Cited by 5 publications

References 30 publications

Evaluation of the migration of chemicals from baby bottles under standardised and duration testing conditions

Evaluation of the migration of chemicals from baby bottles under standardised and duration testing conditions

Bisphenol A migration from plastic materials: direct insight of ecotoxicity in Daphnia magna

New Trends in the Analysis of Endocrine Disrupting Compounds in Environmental Samples

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