“…9 It has a high sensitivity (87%), detecting all classes of genotoxin: mutagens, promutagens, clastogens, and aneugens. 9,10 Specificity is a key characteristic for screening, and the assay's specificity (95%) 9,10 is higher than those historically reported for Ames 3 (sensitivity 60.3%, specificity 77.3%), the Micronucleus Test (MNT: 13,14 GFP reporters enable the development of simple, reagentfree assays and, partly as a consequence of this, are more amenable to moderate-throughput screening applications than the earlier generation of antibiotic resistance and other enzyme-linked reporter genes. There are, however, some applications in which assay users are prepared to accept additional handling steps if a higher signal-to-noise ratio can be obtained.…”