Interlaboratory analysis of teicoplanin plasma concentration assays among Chinese laboratories

Wang, Xiaoxue; Jin, Pengfei; Li, Pengmei; Kong, Xudong; Qin, Wei; Chen, Wen‐Qian; Qin, Wangjun; Zhang, Xianglin

doi:10.1111/jcpt.13115

Cited by 4 publications

(6 citation statements)

References 17 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the quantification range was wide with a concentration of up to 500 mg/L. This is beneficial as our clinical target is critically ill patients that have complex clinical characteristics including the prolonged high-dose administration of teicoplanin that depends on perfusion status, infection site, and multidrug-resistance, while most methods using LC-MS/MS or HPLC-UV are available to quantify up to 100 mg/L [14,20,22,23] or 200 mg/L [16].…”

Section: Validation Of the Optimized Method: Specificity Linearity Sensitivity Accuracy Precision Recovery And Stabilitymentioning

confidence: 99%

“…The HPLC-UV method using IS for teicoplanin analysis is seldom. One publication reported a practically available HPLC-UV method using piperacillin as the IS [23].…”

Section: 2mentioning

confidence: 99%

“…The use of an internal standard (IS) for quantitation of a target analyte by HPLC is pertinent to remove experimental errors associated with sample preparation procedures. The use of an internal standard when analyzing teicoplanin has been reported, including mephenesin [19], risticetin [16], polymyxin B [14,20], daptomycin [21,22], and piperacillin sodium [23]. Mephenesin has different chemical properties (hydrophobic) from teicoplanin, and risticetin, polymyxin B, and daptomycin were used for LC-MS/MS [14,16,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…Mephenesin has different chemical properties (hydrophobic) from teicoplanin, and risticetin, polymyxin B, and daptomycin were used for LC-MS/MS [14,16,[20][21][22]. Recently, Wang et al reported an HPLC-UV method using piperacillin as an IS in Chinese patients [23], but their method was not capable of monitoring over 100 mg/L of the antibiotic in patient plasma.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quantification of Teicoplanin Using the HPLC-UV Method for Clinical Applications in Critically Ill Patients in Korea

et al. 2021

View full text Add to dashboard Cite

A high-performance liquid chromatography-ultraviolet detector (HPLC-UV) method has been used to quantify teicoplanin concentrations in human plasma. However, the limited analytical accuracy of previously bioanalytical methods for teicoplanin has given rise to uncertainty due to the use of an external standard. In this study, an internal standard (IS), polymyxin B, was applied to devise a precise, accurate, and feasible HPLC-UV method. The deproteinized plasma sample containing teicoplanin and an IS of acetonitrile was chromatographed on a C18 column with an acidic mobile phase consisting of NaH2PO4 buffer and acetonitrile (78:22, v/v) by isocratic elution and detection at 220 nm. The linearity was in the range 7.8–500 mg/L calculated by the ratio of the teicoplanin signal to the IS signal. This analytical method, validated by FDA guidelines with ICH Q2 (R1), was successfully applied to analyze the plasma samples of patients in the intensive care unit for treating serious resistant bacterial infectious diseases, such as those by methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. The methods suggested the potential for use in routine clinical practice for therapeutic drug monitoring of teicoplanin, providing both improved accuracy and a wide range of linearity from lower than steady-state trough concentrations (10 mg/L) to much higher concentrations.

show abstract

Section: Validation Of the Optimized Method: Specificity Linearity Sensitivity Accuracy Precision Recovery And Stabilitymentioning

confidence: 99%

“…The HPLC-UV method using IS for teicoplanin analysis is seldom. One publication reported a practically available HPLC-UV method using piperacillin as the IS [23].…”

Section: 2mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantification of Teicoplanin Using the HPLC-UV Method for Clinical Applications in Critically Ill Patients in Korea

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Remarkably, the increase in formic acid might lead the elution efficiency of RAM and TA3-1 to 80%. Meanwhile, it might cause their degradation and not reach satisfactory recovery (Wang et al, 2020). Thus, a solvent with suitable polarity was explored by adjusting the proportion of methanol, water, and formic acid.…”

Section: Optimization Of Cascade Elutionmentioning

confidence: 99%

Simultaneous Determination of Active Clinical Components of Teicoplanin and Ramoplanin in Environmental Water by LC-MS/MS Coupled With Cascade Elution

Jin

Zhao

Yin

et al. 2021

Front. Environ. Sci.

View full text Add to dashboard Cite

A simple, sensitive, and simultaneous method was established and validated for the active clinical components of teicoplanin and ramoplanin in environmental water by LC-MS/MS coupled with cascade elution. Moreover, a cascade elution method, which was rapid, solvent-less, and high-extraction efficient was successfully proposed to realize the extraction and purification of seven targets in one step. Under optimized conditions, the method showed excellent linearity with the correlation coefficient (R2) ≥0.998 in the range of 1.0–100.0 ng L−1. Low matrix effects and good recoveries which ranged from 86 to 114% were reached with RSDs lower than 3.0% for most targets. The limits of detection and limit of quantification were 0.1–1.3 and 0.3–4.0 ng L−1, respectively. This method was successfully applied for the determination of teicoplanin and ramoplanin in water samples from the Pearl River and the South China Sea. TA2-2,3 was quantified in only one sample with the concentration of 8.0 ng L−1.

show abstract

Development and Validation of a High-Performance Liquid Chromatography With Ultraviolet Detection Method to Facilitate Therapeutic Monitoring of Teicoplanin Using Dried Blood Spots

Ramadan,

Opitz,

Hempel

2024

Therapeutic Drug Monitoring

View full text Add to dashboard Cite

Background: In neonatal and pediatric intensive care units, Gram-positive infections are a significant cause of morbidity and mortality. The increase in infections caused by methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococci have led to the increased use of glycopeptides, which treat invasive infections caused by Gram-positive organisms, particularly those resistant to beta-lactam antibiotics. Teicoplanin has bacteriostatic activity against Gram-positive bacteria, but its pharmacokinetics in children is highly variable, with most children failing to reach target levels at the recommended dose. This study aimed to develop a cost-effective method for determining concentrations using dried blood spot (DBS). Methods: A method to determine the concentrations of teicoplanin in 20 µL blood or plasma using the Whatman 903 Protein Saver filter was evaluated. High-performance liquid chromatography with ultraviolet detection high-performance liquid chromatography with ultraviolet/vis was used, with internal standard ketoconazole. In addition, a method to quantify teicoplanin using 50 µL of liquid plasma was established to compare the results with the values obtained by DBS and dried plasma methods. Results: The method was successfully developed and validated for 20 µL DBS. Furthermore, 50 µL of plasma was used to quantify teicoplanin with a lower limit of quantification of 10 mg/L. Precision and accuracy ranged from 2.3% to 10.7% and 95%–114.2%, respectively. A consistent factor (1.15) was used to calculate teicoplanin plasma concentrations from whole blood, indicating the reliability of the DBS method for therapeutic drug monitoring of teicoplanin. Conclusions: A simple, reliable, and cost-effective method using high-performance liquid chromatography with ultraviolet/vis was established to determine pediatric teicoplanin concentrations in both small plasma sample volumes and whole blood using DBS, and an accurate correlation factor for estimating teicoplanin plasma concentrations from DBS was identified. This method is suitable for the use in pediatrics.

show abstract

Interlaboratory analysis of teicoplanin plasma concentration assays among Chinese laboratories

Cited by 4 publications

References 17 publications

Quantification of Teicoplanin Using the HPLC-UV Method for Clinical Applications in Critically Ill Patients in Korea

Quantification of Teicoplanin Using the HPLC-UV Method for Clinical Applications in Critically Ill Patients in Korea

Simultaneous Determination of Active Clinical Components of Teicoplanin and Ramoplanin in Environmental Water by LC-MS/MS Coupled With Cascade Elution

Development and Validation of a High-Performance Liquid Chromatography With Ultraviolet Detection Method to Facilitate Therapeutic Monitoring of Teicoplanin Using Dried Blood Spots

Contact Info

Product

Resources

About