Interindividual variation of the organism - as an indicator for assessing the severity of heat stroke in an experimental study of Wistar rats

Abstract

Introduction Autopsies are often performed, but the evidence is insufficient and non-specific. The aim of the research was to determine the core temperature values of rats exposed to different water temperatures (37°C, 41°C, 44°C), before the start of the experiment (Tb), after immersion in water (Tu), after 20 minutes of exposure (Tu) and at death. (Ts) rats for the purpose of hyperthermia and heat stroke. Material and Method Forty rats were divided into five groups depending on the temperature and length of exposure to water: control group-CG37, G41-hyperthermia- group which exposure time was a 20 minutes on 41°C, G41-heat stroke- group exposed until death on 41°C, G44- hyperthermia- group which exposure time was a 20 minutes on 44°C, G44- heat stroke- group exposed until death on 44°C. A RET-4 probe was used to measure the core temperature of rats. Results Significant changes in the body temperature of rats were observed during the lethal outcome, p < 0.0005. A significant difference was also observed in postmortem temperature of groups G41 and G44, p = 0.01. a significant difference between body temperatures in groups CG37, G41-hyperthermia, G41- heat stroke, G44-hyperthermia and G44-heat stroke (p < 0.0005), and the significance of the differences in the CG37 group was p = 0.044. Conclusion Exposure of albino rats to different water temperatures also led to a change in the internal temperature; normothermia was established through thermoregulation in the control group, and in the other groups, hyperthermia and heat stress occurred.