Interindividual variability of phenol‐ and catechol‐sulphotransferases in platelets from adults and newborns

Pacifici, Gian Maria; Marchi, G. De

doi:10.1111/j.1365-2125.1993.tb00420.x

Brit J Clinical Pharma

1993

DOI: 10.1111/j.1365-2125.1993.tb00420.x

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Interindividual variability of phenol‐ and catechol‐sulphotransferases in platelets from adults and newborns

Gian Maria Pacifici¹,

G. De Marchi²

Abstract: (adult) and 4.80 ± 4.34 (newborn) pmol min-' mg-', respectively (P < 0.001). The coefficients of variation were 107% (adult) and 90% (newborn). The frequency distribution of sulphotransferase activity was positively skewed in both newborn and adult platelets. 4 Since sulphotransferase activity in platelets is well-expressed at birth and a prenatal development of sulphotransferase has been described in mid-gestational human foetal liver, the newborn should be able to sulphate drugs.

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Cited by 8 publications

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Human liver budesonide sulphotransferase is inhibited by testosterone and correlates with by testosterone sulphotransferase

Pacifici

Ferroni

Temellini

et al. 1994

Eur J Clin Pharmacol

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Budesonide, a corticosteroid used in the treatment of asthma and allergic reactions, is almost entirely cleared by metabolism in man. We describe the sulphation of budesonide in human liver and lung and provide evidences that the sulphation of budesonide is catalysed by testosterone sulphotransferase. A rapid and reproducible radiometric assay for budesonide sulphotransferase is described. Liver specimens were obtained from 35 men and 65 women and lung specimens from 2 women and 17 men. The average hepatic budesonide sulphation rate was significantly higher in men (41.1 pmol.min-1.ml-1) than women (28.2 pmol.min-1.mg-1). In the lung, the mean budesonide sulphation rate was 5.0 pmol.min-1.mg-1. Testosterone strongly inhibited the hepatic sulphation of budesonide, whereas p-nitrophenol and dopamine were poor inhibitors; the IC50 was 7.0 uM (testosterone), 320 uM (p-nitrophenol) and 510 uM (dopamine). The hepatic rates of testosterone, p-nitrophenol and dopamine sulphation were measured in the same samples assayed for budesonide sulphotransferase. There was a correlation between the hepatic rates of budesonide and testosterone sulphation (P < 0.001; r = 0.810). The activity of testosterone sulphotransferase was significantly greater in men than women (22.0 vs. 17.2 pmol.min-1.mg-1), whereas those of dopamine and p-nitrophenol sulphotransferase were not sex dependent.(ABSTRACT TRUNCATED AT 250 WORDS)

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Human liver budesonide sulphotransferase is inhibited by testosterone and correlates with by testosterone sulphotransferase

Pacifici

Ferroni

Temellini

et al. 1994

Eur J Clin Pharmacol

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Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population

Ferroni

Marchi²,

Sansone

et al. 1996

European Journal of Clinical Pharmacology

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We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95% confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial.

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Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns

Brittelli

Santi

Raunio³

et al. 1999

European Journal of Clinical Pharmacology

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Interindividual variability of phenol‐ and catechol‐sulphotransferases in platelets from adults and newborns

Cited by 8 publications

References 32 publications

Human liver budesonide sulphotransferase is inhibited by testosterone and correlates with by testosterone sulphotransferase

Human liver budesonide sulphotransferase is inhibited by testosterone and correlates with by testosterone sulphotransferase

Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population

Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns

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