Interindividual Variability in Functional Connectivity as Long-Term Correlate of Temporal Discounting

Calluso, Cinzia; Tosoni, Annalisa; Pezzulo, Giovanni; Spadone, Sara; Committeri, Giorgia

doi:10.1371/journal.pone.0119710

Cited by 22 publications

(16 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After accounting for age, sex, and the time interval between the acquisition of the DTI data and the DoG assessment, enhanced white matter connectivity between the right dorsal prefrontal cortex and the caudate nucleus revealed to be significantly related to the acquisition (i.e., training) phase, but not related to the maintenance of the DoG ability. Further support for the association between DoG or DD on the one hand and structural and functional frontostriatal connectivity strength on the other has been reported elsewhere in the human and animal literature (Kim et al, 2012; Jimura et al, 2013; Li et al, 2013; Benningfield et al, 2014; Calluso et al, 2015) and therefore will not be reiterated in detail here.…”

Section: Discussionmentioning

confidence: 52%

Strength of Structural and Functional Frontostriatal Connectivity Predicts Self-Control in the Healthy Elderly

Hänggi

Lohrey

Drobetz

et al. 2016

Front. Aging Neurosci.

View full text Add to dashboard Cite

Self-regulation refers to the successful use of executive functions and initiation of top-down processes to control one's thoughts, behavior, and emotions, and it is crucial to perform self-control. Self-control is needed to overcome impulses and can be assessed by delay of gratification (DoG) and delay discounting (DD) paradigms. In children/adolescents, good DoG/DD ability depends on the maturity of frontostriatal connectivity, and its decline in strength with advancing age might adversely affect self-control because prefrontal brain regions are more prone to normal age-related atrophy than other regions. Here, we aimed at highlighting the relationship between frontostriatal connectivity strength and DoG performance in advanced age. We recruited 40 healthy elderly individuals (mean age 74.0 ± 7.7 years) and assessed the DoG ability using the German version of the DoG test for adults in addition to the delay discounting (DD) paradigm. Based on diffusion-weighted and resting-state functional magnetic resonance imaging data, respectively, the structural and functional whole-brain connectome were reconstructed based on 90 different brain regions of interest in addition to a 12-node frontostriatal DoG-specific network and the resulting connectivity matrices were subjected to network-based statistics. The 90-nodes whole-brain connectome analyses revealed subnetworks significantly associated with DoG and DD with a preponderance of frontostriatal nodes involved suggesting a high specificity of the findings. Structural and functional connectivity strengths between the putamen, caudate nucleus, and nucleus accumbens on the one hand and orbitofrontal, dorsal, and ventral lateral prefrontal cortices on the other hand showed strong positive correlations with DoG and negative correlations with DD corrected for age, sex, intracranial volume, and head motion parameters. These associations cannot be explained by differences in impulsivity and executive functioning. This pattern of correlations between structural or functional frontostriatal connectivity strength and self-control suggests that, in addition to the importance of the frontostriatal nodes itself, the structural and functional properties of different connections within the frontostriatal network are crucial for self-controlled behaviors in the healthy elderly. Because high DoG/low DD is a significant predictor of willpower and wellbeing in the elderly population, interventions aiming at strengthening frontostriatal connectivity to strengthen self-controlled behavior are needed in the future.

show abstract

Section: Discussionmentioning

confidence: 52%

Strength of Structural and Functional Frontostriatal Connectivity Predicts Self-Control in the Healthy Elderly

Hänggi

Lohrey

Drobetz

et al. 2016

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…During the baseline intertemporal choice task, participants were asked to make a series of hypothetical (i.e., subjects did not receive any payment for their participation in the study) choices between an immediate fixed amount of money (i.e., 10€) and a delayed one. The latter option was parametrically manipulated across seven amounts (i.e., 15€, 25€, 30€, 40€, 45€, 55€ and 60€) and six waiting times (i.e., 7, 15, 30, 60, 90, and 180 days), thus obtaining 42 different choice pairs (see [42,45,46] for a similar task design; Fig 1A). Each choice pair was repeated five times for each condition, thus resulting in a total of 210 trials.…”

Section: Methodsmentioning

confidence: 99%

Concreteness and emotional valence of episodic future thinking (EFT) independently affect the dynamics of intertemporal decisions

et al. 2019

Self Cite

View full text Add to dashboard Cite

During intertemporal decisions, the value of future rewards decreases as a function of the delay of its receipt (temporal discounting, TD). Since high discount rates have been associated with a series of problematic behaviours and clinical conditions, current research has focused on possible modulators of TD. Specifically, a reduction of individual discount rates has been shown during episodic future thinking (EFT), wherein time intervals are anchored to personal future events. However, it is not entirely clear whether this effect is mediated by a change in the representation of future events (i.e., from abstract to concrete) or by a positive-emotion modulation. Here, we investigated this issue by manipulating the valence of the EFT (i.e., using negative, neutral and positive episodic tags), and by collecting explicit and implicit measures of behaviour. The results showed a significant reduction of TD in all the three emotional conditions compared to the baseline, with differences among them, thus suggesting the existence of a cumulative effect of the concreteness and affective components of the EFT. The analyses of implicit measures additionally revealed that this effect was mediated by a simultaneous increase/decrease of attraction toward the delayed/immediate alternative. Finally, these effects appeared to be modulated by participants’ baseline discounting preferences. These findings provide important insights on clinical applications in reward-related disorders.

show abstract

“…These studies documented a positive correlation between the degree of delay discounting and the strength of functional connectivity among components of the valuation network [43,44]. Such positive association was observed with the connectivity between the ventral striatum (VS) and the ventromedial prefrontal cortex (vmPFC) both in adults [43] and in children [45].…”

Section: Functional Connectivitymentioning

confidence: 99%

Neural markers of individual differences in decision-making

Kable

Levy

2015

Current Opinion in Behavioral Sciences

View full text Add to dashboard Cite

In the last few years, neuroscientists have begun to identify associations between individual differences in decision-making and features of neuroanatomy and neurophysiology. Different tendencies in decision making, such as tolerance for risk, delay or effort, have been linked to various neurobiological measures, such as morphometry, structural connectivity, functional connectivity or the function of neurotransmitter systems. Though far from immutable, these neural features may nonetheless be suitable as relatively stable biomarkers for different decision traits. The establishment of such markers would achieve one of the stated goals of neuroeconomics, which is to improve the prediction of economic behavior across different contexts.

show abstract

Interindividual Variability in Functional Connectivity as Long-Term Correlate of Temporal Discounting

Cited by 22 publications

References 92 publications

Strength of Structural and Functional Frontostriatal Connectivity Predicts Self-Control in the Healthy Elderly

Strength of Structural and Functional Frontostriatal Connectivity Predicts Self-Control in the Healthy Elderly

Concreteness and emotional valence of episodic future thinking (EFT) independently affect the dynamics of intertemporal decisions

Neural markers of individual differences in decision-making

Contact Info

Product

Resources

About