2013
DOI: 10.1016/j.clon.2012.11.002
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Interim Data from the Medical Research Council QUARTZ Trial: Does Whole Brain Radiotherapy Affect the Survival and Quality of Life of Patients with Brain Metastases from Non-small Cell Lung Cancer?

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Cited by 89 publications
(55 citation statements)
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“…53 A recent phase III non-inferiority trial in patients with brain metastases from NSCLC, not a candidate for either surgery or radiosurgery, has not shown differences in OS and quality of life between WBRT and supportive care (class I). 54 To date, radiosensitizers have not provided any clear additional benefit over conventional radiotherapy.…”
Section: Whole-brain Radiotherapymentioning
confidence: 99%
“…53 A recent phase III non-inferiority trial in patients with brain metastases from NSCLC, not a candidate for either surgery or radiosurgery, has not shown differences in OS and quality of life between WBRT and supportive care (class I). 54 To date, radiosensitizers have not provided any clear additional benefit over conventional radiotherapy.…”
Section: Whole-brain Radiotherapymentioning
confidence: 99%
“…A recent audit of clinical practice in Nordland Hospital (Bodø, Nordland, Norway) between 2007 and 2009 revealed that 9% of all palliative radiotherapy was administered to patients during their last month of life (10). In other words, the physician's decision-making was appropriate in ~9 out of 10 patients, based on the assumption that patients with extremely short survival time are unlikely to experience any significant improvement in symptoms or quality of life (11). Due to the lack of patient-reported outcomes, the clinical benefit of palliative radiotherapy during the last month of life was not analyzed in the present study.…”
Section: Introductionmentioning
confidence: 99%
“…However, data on the purported benefit of WBrT are highly controversial. The QUarTZ study found no significant benefit of adding WBrT in non-small cell lung cancer (Nsclc) patients 8 and Nieder et al also confirmed that there was no significant benefit of WBrT with one exception and that was a group of patients with small cell lung cancer. This small sub-group benefited from a WBrT of 30 Gy (ref.…”
Section: Discussionmentioning
confidence: 75%