Interictal Patterns of Cerebral Glucose Metabolism, Perfusion, and Magnetic Field in Mesial Temporal Lobe Epilepsy

Sakamoto, Shinichi; Tsuyuguchi, Naohiro; Takami, Toshihiro; Morino, Michiharu; Goto, Takeo; Hattori, Hideji; Tsutada, Tsuyoshi; Haque, Moududul; Sunada, Ichiro; Shimogawara, Masahiro; Hara, Mitsuhiro

doi:10.1046/j.1528-1157.2003.08603.x

Cited by 19 publications

(12 citation statements)

References 44 publications

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“…The spatial pattern of this network was similar to that of the temporal epileptic network reported in other studies using different imaging modalities [Bernhardt et al, 2008;Blumenfeld et al, 2004;Spencer, 2002;Tae et al, 2005]. Although a general consensus has been reached that the hippocampus is the key of the epileptogenic focus, increasing evidence has shown that widespread brain structures, including the bilateral mesial temporal structures [Bernhardt et al, 2008;Seidenberg et al, 2005;Spencer, 2002], neocortices such as the lateral temporal [Blumenfeld et al, 2004;Tae et al, 2005] and parietal lobes [Englot et al, 2008;Nelissen et al, 2006;Tae et al, 2005], subcortical structures such as the thalamus [Labate et al, 2008;Schwarcz et al, 2002;Yune et al, 1998], basal ganglia and pontine nuclei [Bouilleret et al, 2005] etc., compose a reciprocal mesial temporal epileptic network contributing to the process of mTLE [Blumenfeld et al, 2004;Sakamoto et al, 2003;Spencer, 2002]. The largely overlapped results might implicate that the widespread increased ALFF is underpinned by the mesial temporal epileptic network proposed by Spencer [2002].…”

Section: Regions Showing Increased Alff and The Temporal Epileptic Nementioning

confidence: 90%

fMRI study of mesial temporal lobe epilepsy using amplitude of low‐frequency fluctuation analysis

Zhang

Zhong

et al. 2010

Human Brain Mapping

179

163

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Various functional imaging tools have been used to detect epileptic activity in the neural network underlying mesial temporal lobe epilepsy (mTLE). In the present fMRI study, a data-driven approach was employed to map interictal epileptic activity in mTLE patients by measuring the amplitude of low-frequency fluctuation (ALFF) of the blood oxygen level-dependent (BOLD) signal. Twenty-four left mTLE patients and 26 right mTLE patients were investigated by comparing with 25 healthy subjects. In the patients, the regions showing increased ALFF were consistently distributed in the mesial temporal lobe, thalamus, and a few of other cortical and subcortical structures composing a mesial temporal epilepsy network proposed previously, while the regions showing decreased ALFF were mostly located in the areas of so-called default-mode network. Data of simultaneous EEG-fMRI from a portion of the patients suggested that the increases in ALFF might be associated with the interictal epileptic activity. Individual analyses based on statistic parametric mapping revealed a moderate sensitivity and a fairly high specificity for the lateralization of unilateral mTLE. We conclude that the ALFF analysis may provide a useful tool in fMRI study of epilepsy.

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Section: Regions Showing Increased Alff and The Temporal Epileptic Nementioning

confidence: 90%

fMRI study of mesial temporal lobe epilepsy using amplitude of low‐frequency fluctuation analysis

Zhang

Zhong

et al. 2010

Human Brain Mapping

179

163

View full text Add to dashboard Cite

show abstract

“…The aim of our study was to determine the changes and sensitivity of interictal EEG in demonstrating the pathological abnormality and evaluate the presence of paroxysm of epileptiform discharges with clinically suspected seizure events. Other technologies currently used for epileptic focus lateralization, such as magneto electroencephalography (MEG) and functional magnetic resonance imaging ( f MRI) also depend largely on analysis of interictal spikes (Sakamoto et al 2003; Al-Asmi et al 2003). …”

Section: Introductionmentioning

confidence: 99%

Interictal EEG changes in patients with seizure disorder: experience in Bangladesh

et al. 2013

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The objective of this study was to determine the changes and sensitivity of electro encephalogram during interictal period and to evaluate the finding in the clinically suspected seizure events in a tertiary care hospital of Bangladesh. This cross sectional study was carried out in the Electrophysiology Laboratory of Dhaka Medical College Hospital from July 2010 to July 2011, which included 767 patients. EEG was obtained through scalp electrodes following international 10/20 system. Patient and their attendants were interviewed using a semi structured questionnaire. The EEG findings and clinical seizure events were then compared. Among the 767 epilepsy patients most were children (39.9% less than 10 years old) and young adult (33.2% in 11–20 years age group). Female patients predominantly had seizure than male (57% and 43% respectively). The overall sensitivity of EEG in yielding abnormal interictal epileptiform discharges was 62.7%. About 48.5% of them were diagnosed as localization related epilepsy and 11.7% were generalized epilepsy. Morphology showed spike and wave in 74% and sharp and wave in 11% tracings. Only 2% had slow waves. The presence of an interictal spike/sharp wave helps to confirm a clinical diagnosis of epilepsy, aids in defining the epilepsy syndrome, provides information that assists in planning drug management.

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“…The promising applications of a wide variety of functional neuroimaging options for assessing epileptic foci as well as ictal and interictal perfusion patterns further emphasizes the need to carefully define pathways linking medial temporal lobe structures with motor cortex. For example, brain activation patterns accompanying seizures are currently interpreted utilizing the existing body of anatomical knowledge to classify seizures, localize and lateralize epileptogenic foci, assess seizure propagation pathways, guide presurgical strategies, and predict postoperative seizure outcomes following surgical intervention (Engel et al,1983; Stefan et al,1990; Rowe et al,1991; Marks et al,1992; Theodore et al,1992; Kuzniecky et al,1993; Radtke et al,1993; Ho et al,1997; Laich et al,1997; Duncan,2000; Rosenow and Lûders,2001; Wichert‐Ana et al,2001; Antel et al,2002; Sakamoto et al,2003; Joo et al,2005; Tae et al,2005). Therefore, accurate characterization of medial temporal projection patterns remains a priority for developing palliative and beneficial epileptic surgical strategies.…”

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confidence: 99%

Amygdala interconnections with the cingulate motor cortex in the rhesus monkey

Morecraft

McNeal

Stilwell-Morecraft

et al. 2006

J of Comparative Neurology

134

120

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Amygdala interconnections with the cingulate motor cortices were investigated in the rhesus monkey. Using multiple tracing approaches, we found a robust projection from the lateral basal nucleus of the amygdala to Layers II, IIIa, and V of the rostral cingulate motor cortex (M3). A smaller source of amygdala input arose from the accessory basal, cortical, and lateral nuclei, which targeted only the rostral region of M3. We also found a light projection from the lateral basal nucleus to the same layers of the caudal cingulate motor cortex (M4). Experiments examining this projection to cingulate somatotopy using combined neural tracing strategies and stereology to estimate the total number of terminal-like immunoreactive particles demonstrated that the amygdala projection terminates heavily in the face representation of M3 and moderately in its arm representation. Fewer terminal profiles were found in the leg representation of M3 and the face, arm, and leg representations of M4. Anterograde tracers placed directly into M3 and M4 revealed the amygdala connection to be reciprocal and documented corticofugal projections to the facial nucleus, surrounding pontine reticular formation, and spinal cord. Clinically, such pathways would be in a position to contribute to mediating movements in the face, neck, and upper extremity accompanying medial temporal lobe seizures that have historically characterized this syndrome. Alterations within or disruption of the amygdalo-cingulate projection to the rostral part of M3 may also have an adverse effect on facial expression in patients presenting with neurological or neuropsychiatric abnormalities of medial temporal lobe involvement. Finally, the prominent amygdala projection to the face region of M3 may significantly influence the outcome of higher-order facial expressions associated with social communication and emotional constructs such as fear, anger, happiness, and sadness.

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Interictal Patterns of Cerebral Glucose Metabolism, Perfusion, and Magnetic Field in Mesial Temporal Lobe Epilepsy

Cited by 19 publications

References 44 publications

fMRI study of mesial temporal lobe epilepsy using amplitude of low‐frequency fluctuation analysis

fMRI study of mesial temporal lobe epilepsy using amplitude of low‐frequency fluctuation analysis

Interictal EEG changes in patients with seizure disorder: experience in Bangladesh

Amygdala interconnections with the cingulate motor cortex in the rhesus monkey

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