Interictal epileptiform discharges shape large-scale intercortical communication

Dahal, Prawesh; Ghani, Naureen; Flinker, Adeen; Dugan, Patricia; Friedman, Daniel J.; Doyle, Werner; Devinsky, Orrin; Khodagholy, Dion; Gelinas, Jennifer N.

doi:10.1093/brain/awz269

Cited by 63 publications

(67 citation statements)

References 59 publications

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“…We detected spindle band oscillations, which were present in pups of all ages, to facilitate comparisons. We quantified spatial extent using the two-dimensional organization of the NeuroGrid to determine the proportion of electrodes expressing co-occurring spindle band oscillations with a reference electrode located in primary somatosensory cortex ( Figure 3A) (42). Waveform was characterized using an asymmetry index ( Figure 3B) and power was extracted from the filtered Hilbert envelope ( Figure 3C).…”

Section: Resultsmentioning

confidence: 99%

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

Domínguez

Yu³

et al. 2021

Preprint

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Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neural networks to perform complex computations remains unknown. We investigate the progression of large-scale synaptic and cellular activity patterns across development using high spatiotemporal resolution in vivo electrophysiology in immature mice. We reveal that mature cortical processes emerge rapidly and simultaneously after a discrete but volatile transition period at the beginning of the second postnatal week of rodent development. The transition is characterized by relative neural quiescence, after which spatially distributed, temporally precise, and internally organized activity occurs. We demonstrate a similar developmental trajectory in humans, suggesting an evolutionarily conserved mechanism to transition network operation. We hypothesize that this transient quiescent period is a requisite for the subsequent emergence of coordinated cortical networks.

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Section: Resultsmentioning

confidence: 99%

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

Domínguez

Yu³

et al. 2021

Preprint

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“…Gelinas et al 83 showed that hippocampal interictal spikes induced spindle generation in frontal region during NREM sleep but also during REM sleep and wakefulness, suggesting that hippocampal spikes produce changes in sleep architecture across large networks involved in normal sleep. The same group also showed that the dynamic oscillatory coupling between interictal epileptic discharges and sleep spindles induces network alteration outside the EZ 84 …”

Section: Sleep and Alfmentioning

confidence: 96%

“…The same group also showed that the dynamic oscillatory coupling between interictal epileptic discharges and sleep spindles induces network alteration outside the EZ. 84…”

Section: Insight From Intracranial Electroencephalographic Recordingsmentioning

confidence: 99%

Accelerated long‐term forgetting in focal epilepsy: Do interictal spikes during sleep matter?

et al. 2021

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Accelerated long‐term forgetting (ALF) is a particular form of amnesia mostly encountered in focal epilepsy, particularly in temporal lobe epilepsy. This type of memory loss is characterized by an impairment of long‐term consolidation of declarative memory, and its mechanisms remain poorly understood. In particular, the respective contribution of lesion, seizures, interictal epileptic discharges, and sleep is still debated. Here, we provide an overview of the relationships intertwining epilepsy, sleep, and memory consolidation and, based on recent findings from intracranial electroencephalographic recordings, we propose a model of ALF pathophysiology that integrates the differential role of interictal spikes during wakefulness and sleep. This model provides a framework to account for the different timescales at which ALF may occur.

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“…By extension, IEDs could conceivably disrupt the organization and functioning of WM networks. Indeed, large-scale network changes precede ( Ibrahim et al, 2014 ) and follow IEDs ( Lengler et al, 2007 ; Ibrahim et al, 2014 ; Dahal et al, 2019 ). Moreover, the vulnerability of network topologies to IEDs has previously been associated with worse neurocognitive outcomes ( Ibrahim et al, 2014 ).…”

Section: Pathophysiological Mechanisms Of Wm Impairment In Epilepsymentioning

confidence: 99%

The Oscillatory Basis of Working Memory Function and Dysfunction in Epilepsy

Arski

Young

Smith

et al. 2021

Front. Hum. Neurosci.

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Working memory (WM) deficits are pervasive co-morbidities of epilepsy. Although the pathophysiological mechanisms underpinning these impairments remain elusive, it is thought that WM depends on oscillatory interactions within and between nodes of large-scale functional networks. These include the hippocampus and default mode network as well as the prefrontal cortex and frontoparietal central executive network. Here, we review the functional roles of neural oscillations in subserving WM and the putative mechanisms by which epilepsy disrupts normative activity, leading to aberrant oscillatory signatures. We highlight the particular role of interictal epileptic activity, including interictal epileptiform discharges and high frequency oscillations (HFOs) in WM deficits. We also discuss the translational opportunities presented by greater understanding of the oscillatory basis of WM function and dysfunction in epilepsy, including potential targets for neuromodulation.

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Interictal epileptiform discharges shape large-scale intercortical communication

Cited by 63 publications

References 59 publications

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

Accelerated long‐term forgetting in focal epilepsy: Do interictal spikes during sleep matter?

The Oscillatory Basis of Working Memory Function and Dysfunction in Epilepsy

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