Interictal epileptiform discharges in Alzheimer’s disease: prevalence, relevance, and controversies

Lemus, Hernan Nicolas; Sarkis, Rani A.

doi:10.3389/fneur.2023.1261136

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…The role of PV+ neurons in AD and DLB is important to understand because E/I imbalances occur leading to an increased risk of epilepsy in patients with AD [ 124 ]. Although most patients with sporadic AD do not present with overt clinical seizures, other indicators of abnormal network hyperexcitability, such as interictal discharges occur [ 125 ]. Moreover, seizures can be nocturnal or non-convulsive [ 126 ] and thus may be under-recognised and therefore under-reported.…”

Section: Parvalbumin Neuron Deficits In Alzheimer's Disease and Demen...mentioning

confidence: 99%

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Olkhova,

Smith,

Dennis

et al. 2024

Biochemical Society Transactions

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Given the current paucity of effective treatments in many neurological disorders, delineating pathophysiological mechanisms among the major psychiatric and neurodegenerative diseases may fuel the development of novel, potent treatments that target shared pathways. Recent evidence suggests that various pathological processes, including bioenergetic failure in mitochondria, can perturb the function of fast-spiking, parvalbumin-positive neurons (PV+). These inhibitory neurons critically influence local circuit regulation, the generation of neuronal network oscillations and complex brain functioning. Here, we survey PV+ cell vulnerability in the major neuropsychiatric, and neurodegenerative diseases and review associated cellular and molecular pathophysiological alterations purported to underlie disease aetiology.

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Section: Parvalbumin Neuron Deficits In Alzheimer's Disease and Demen...mentioning

confidence: 99%

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Olkhova,

Smith,

Dennis

et al. 2024

Biochemical Society Transactions

View full text Add to dashboard Cite

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Alzheimer’s Disease and Epilepsy: Exploring Shared Pathways and Promising Biomarkers for Future Treatments

Kalyvas,

Dimitriou,

Ioannidis

et al. 2024

JCM

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Background: Alzheimer’s disease (AD) and epilepsy represent two complex neurological disorders with distinct clinical manifestations, yet recent research has highlighted their intricate interplay. This review examines the association between AD and epilepsy, with particular emphasis on late-onset epilepsy of unknown etiology, increasingly acknowledged as a prodrome of AD. It delves into epidemiology, pathogenic mechanisms, clinical features, diagnostic characteristics, treatment strategies, and emerging biomarkers to provide a comprehensive understanding of this relationship. Methods: A comprehensive literature search was conducted, identifying 128 relevant articles published between 2018 and 2024. Results: Findings underscore a bidirectional relationship between AD and epilepsy, indicating shared pathogenic pathways that extend beyond traditional amyloid-beta and Tau protein pathology. These pathways encompass neuroinflammation, synaptic dysfunction, structural and network alterations, as well as molecular mechanisms. Notably, epileptic activity in AD patients may exacerbate cognitive decline, necessitating prompt detection and treatment. Novel biomarkers, such as subclinical epileptiform activity detected via advanced electroencephalographic techniques, offer promise for early diagnosis and targeted interventions. Furthermore, emerging therapeutic approaches targeting shared pathogenic mechanisms hold potential for disease modification in both AD and epilepsy. Conclusions: This review highlights the importance of understanding the relationship between AD and epilepsy, providing insights into future research directions. Clinical data and diagnostic methods are also reviewed, enabling clinicians to implement more effective treatment strategies.

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Interictal epileptiform discharges in Alzheimer’s disease: prevalence, relevance, and controversies

Cited by 2 publications

References 59 publications

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Alzheimer’s Disease and Epilepsy: Exploring Shared Pathways and Promising Biomarkers for Future Treatments

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