Interictal Abnormalities of Gamma Band Activity in Visual Evoked Responses in Migraine: An Indication of Thalamocortical Dysrhythmia?

Coppola, Gianluca; Ambrosini, Anna; Clemente, Laura Di; Magis, Delphine; Fumal, Arnaud; Gérard, Pascale; Pierelli, Francesco; Schoenen, Jean

doi:10.1111/j.1468-2982.2007.01466.x

Cited by 125 publications

(138 citation statements)

References 37 publications

(75 reference statements)

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“…The appropriate sample size, analysis and presentation of results in a study depend on its primary aim. This may explain the low sample size seen in some studies, as well as why many studies only report the early N70-P100 amplitude component and not the late P100-N145 amplitude component (Afra et al, 2000a;Afra et al, 2000b;Coppola et al, 2007b;Coppola et al, 2011;Coppola et al, 2010a;Coppola et al, 2013b;Di Clemente et al, 2005;Fumal et al, 2006;Ozkul and Bozlar, 2002). However, it is often difficult to evaluate if these studies show that migraineurs lack habitation.…”

Section: Habituation Measured By Visual Evoked Potentials In Migrainementioning

confidence: 98%

“…N70-P100 habituation slope was chosen as primary efficacy parameter because many previous studies only report N70-P100 and not P100-N145 amplitude habituation (Afra et al, 2000b;Coppola et al, 2007b;Coppola et al, 2011;Coppola et al, 2010a;Coppola et al, 2013b;Di Clemente et al, 2005;Ozkul and Bozlar, 2002). Neither N70-P100 nor P100-N145 habituation measures were significantly different between groups.…”

Section: Habituation Measured By Visual Evoked Potentials In Migrainementioning

confidence: 99%

“…Cross-sectional migraine studies often include migraineurs that have on average 2-3 attacks per month, and define the interictal period as > 2 or > 3 days before and after the nearest migraine attack (Coppola et al, 2010a;Di Clemente et al, 2005). Yet, most studies have not reported exclusions of preictal, ictal or postictal recordings, or how these recordings were handled (Afra et al, 1998;Afra et al, 2000b;Bohotin et al, 2002;Coppola et al, 2007b;Coppola et al, 2011;Coppola et al, 2010b;Coppola et al, 2010a;Coppola et al, 2013b;Di Clemente et al, 2005;Fumal et al, 2006;Ozkul and Bozlar, 2002;Schoenen et al, 1995;Vigano et al, 2013). Systematic exclusion of subjects may influence study results and it is therefore unfortunate that most studies do not disclose sufficient details regarding exclusions.…”

Section: Habituation Measured By Visual Evoked Potentials In Migrainementioning

confidence: 99%

“…This was not confirmed in a study that applied 1.9 rps and 31' and 62' checks (Sand et al, 2009), nor in a study that applied 3.0 rps and 8' and 65' checks (Omland et al, 2013). However, most recent VEP habituation studies applied 14-16' checks (Bednar et al, 2014;Coppola et al, 2007b;Coppola et al, 2011;Coppola et al, 2010b;Coppola et al, 2010a;Coppola et al, 2013b). This check size may be preferable because habituation is more pronounced with smaller check sizes (e.g.…”

Section: Introductionmentioning

confidence: 95%

“…Most studies that reported lack of habituation in migraineurs were by one internationally collaborating group of authors (Afra et al, 1998;Afra et al, 2000b;Bohotin et al, 2002;Coppola et al, 2007b;Coppola et al, 2011;Coppola et al, 2010b;Coppola et al, 2010a;Coppola et al, 2013b;Di Clemente et al, 2005;Fumal et al, 2006;Schoenen et al, 1995;Vigano et al, 2013). As far as we know, lack of VEP habituation been independently confirmed in two studies (Bednar et al, 2014;Ozkul and Bozlar, 2002), while two other groups have not managed to reproduce this finding (Oelkers-Ax et al, 2005;Oelkers et al, 1999;Omland et al, 2013;Sand et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Omland

Uglem

Hagen

et al. 2016

Clinical Neurophysiology

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Please cite this article as: Omland, P.M., Uglem, M., Hagen, K., Linde, M., Tronvik, E., Sand, T., Visual evoked potentials in migraine: Is the "neurophysiological hallmark" concept still valid ?, Clinical Neurophysiology (2015), doi: http://dx.doi.org/10. 1016/j.clinph.2014.12.035 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. • Lack of VEP habituation is not a reliable "neurophysiological hallmark" in interictal migraine• Strict focus on methodology, including blinding during the recording and assessment of VEP, is important to avoid overestimation of effect sizes in future studies.2 Abstract Objective Lack of habituation is considered a neurophysiological hallmark of migraine. However, the results of visual evoked potential (VEP) studies have been discrepant, possibly because of different stimulation parameters and lack of blinding. Hence, there is a need for independent confirmation of lack of VEP habituation in migraine. In this blinded study we applied 16' checks to supplement our previous findings with 8', 31', 62' and 65' checks. MethodsVEPs in 41 interictal migraineurs and 30 controls were compared. VEPs were recorded in six blocks of 100 single responses. Linear N70-P100 amplitude change over blocks (habituation slope) was compared with an independent samples Student's t-test. ResultsAmplitude decline over blocks was observed in both groups. Habituation slope was not significantly different between controls (-0.43 ± 0.54 μV/block) and migraineurs (-0.29 ± 0.35 μV/block) (p = 0.33). ConclusionVEP habituation with 16' checks did not differ in migraineurs and controls. This is in agreement with previous findings with other stimulation parameters. It is therefore unlikely that use of different stimulation parameters could explain the discrepant results of previous studies. No studies that applied blinding during recording of VEP have found lack of habituation in migraineurs. SignificanceLack of VEP habituation cannot be considered a reliable neurophysiological hallmark in migraine.

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Section: Habituation Measured By Visual Evoked Potentials In Migrainementioning

confidence: 98%

Section: Habituation Measured By Visual Evoked Potentials In Migrainementioning

confidence: 99%

Section: Habituation Measured By Visual Evoked Potentials In Migrainementioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Omland

Uglem

Hagen

et al. 2016

Clinical Neurophysiology

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Abnormal Thalamo–Cortical Interactions in Overlapping Communities of Migraine: An Edge Functional Connectivity Study

Dai,

Qiu,

Lin

et al. 2023

Annals of Neurology

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ObjectiveMigraine has been demonstrated to exhibit abnormal functional connectivity of large‐scale brain networks, which is closely associated with its pathophysiology and has not yet been explored by edge functional connectivity. We used an edge‐centric approach combined with motif analysis to evaluate higher‐order communication patterns of brain networks in migraine.MethodsWe investigated edge‐centric metrics in 108 interictal migraine patients and 71 healthy controls. We parcellated the brain into networks using independent component analysis. We applied edge graph construction, k‐means clustering, community overlap detection, graph‐theory‐based evaluations, and clinical correlation analysis. We conducted motif analysis to explore the interactions among regions, and a classification model to test the specificity of edge‐centric results.ResultsThe normalized entropy of lateral thalamus was significantly increased in migraine, which was positively correlated with the baseline headache duration, and negatively correlated with headache duration reduction following preventive medications at 3‐month follow‐up. Network‐wise entropy of the sensorimotor network was significantly elevated in migraine. The community similarity between lateral thalamus and postcentral gyrus was enhanced in migraine. Migraine patients showed overrepresented L‐shape and diverse motifs, and underrepresented forked motifs with lateral thalamus serving as the reference node. Furthermore, migraine patients presented with overrepresented L‐shape triads, where the postcentral gyrus shared different edges with the lateral thalamus. The classification model showed that entropy of the lateral thalamus had the highest discriminative power, with an area under the curve of 0.86.InterpretationOur findings indicated an abnormal higher‐order thalamo–cortical communication pattern in migraine patients. The thalamo–cortical–somatosensory disturbance of concerted working may potentially lead to aberrant information flow and deficit pain processing of migraine. ANN NEUROL 2023

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Structural abnormalities in the thalamus of migraineurs with aura: A multiparametric study at 3 T

Granziera

Daducci

Romascano

et al. 2013

Human Brain Mapping

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Interictal Abnormalities of Gamma Band Activity in Visual Evoked Responses in Migraine: An Indication of Thalamocortical Dysrhythmia?

Cited by 125 publications

References 37 publications

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Abnormal Thalamo–Cortical Interactions in Overlapping Communities of Migraine: An Edge Functional Connectivity Study

Structural abnormalities in the thalamus of migraineurs with aura: A multiparametric study at 3 T

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