Interhemispheric lipoma connected to subcutaneous lipoma via lipomatous stalk

Given, Curtis A.; Fields, Tanya M.; Pittman, Thomas

doi:10.1007/s00247-005-1501-z

Cited by 16 publications

(17 citation statements)

References 9 publications

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“…Because of this rostral location, it is thought that tubulonodular lipomas are formed at an earlier time point in development of the corpus callosum (Raybaud 2010). They vary in size, but can extend into the interhemispheric fissure and exit through the cranial sutures, presenting itself as an extracranial mass (Nordin et al, 1955; Zee et al, 1981; Kudoh et al, 1984; Nevin et al, 1999; Given et al, 2005). Tubulonodular lipomas are likely brought about by the delay or failure in resorption of the meninx primitiva along the dorsal midline of the developing telencephalon near the primitive lamina terminalis (Truwit and Barkovich 1990), but the exact cause is unknown.…”

Section: Introductionmentioning

confidence: 99%

Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse

Fong

Cooper

Drumhiller

et al. 2012

Birth Defects Research

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Intracranial lipomas are rare, but 45% of them occur along the midline cisterns between the hemispheres and are often associated with corpus callosum hypoplasia and craniofacial defects. They are difficult to detect, as they are generally asymptomatic and visible by MRI or by postmortem examination. The exact cause of these interhemispheric lipomas is not known, but they arise from a developmental defect resulting in the maldifferentiation of mesenchymal cells into mesodermal derivatives that are not normally present. We have identified a new mouse mutant called tuft, exhibiting a forebrain, intracranial lipoma with midline craniofacial defects resembling frontonasal dysplasia (FND) that arose spontaneously in our wild-type 3H1 colony. The tuft trait appears to be transmitted in recessive fashion, but approximately 80% less frequent than the expected Mendelian 25%, due to either incomplete penetrance or prenatal lethality. MRI and histological analysis revealed that the intracranial lipoma occurred between the hemispheres and often protruded through the sagittal suture. We also observed a lesion at the lamina terminalis that may indicate improper closure of the anterior neuropore. We have mapped the tuft trait to within an 18 cM region on mouse chromosome 10 by microsatellite linkage analysis and identified several candidate genes involved with craniofacial development and cellular differentiation of adipose tissue. tuft is the only known mouse model for midline craniofacial defects with an intracranial lipoma. Identifying the gene(s) and mutation(s) causing this early developmental defect will help us understand the pathogenesis of FND and related craniofacial disorders.

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Section: Introductionmentioning

confidence: 99%

Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse

Fong

Cooper

Drumhiller

et al. 2012

Birth Defects Research

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“…A previous case of cerebellopontine angle lipoma extending to the extracranial space involved a defect in the petrous ridge, 7) and a lipomatous stalk was identified between an interhemispheric lipoma and subcutaneous tissue in a 9-week-old boy. 5) In our case, a lipomatous stalk connected the intra-and extracranial parts of the tumor via a bone defect in the midline parietal region. The intracranial lipoma and epidermoid adhered to each other, and most of the intracranial component was epidermoidal.…”

Section: Discussionmentioning

confidence: 65%

“…Intra-and extracranial components are likely to connect via a bone defect, usually at the midline of the cranial bone. 1,2,5,13) Intracranial lipoma is a rare lesion that accounts for 0.46-1% of intracranial tumors. 16) Only four cases of interhemispheric lipoma connected to subcutaneous lipoma via a bone defect in the anterior fontanel 2,5,13) and midline parietal bone 1) have been reported in infants.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,5,13) Intracranial lipoma is a rare lesion that accounts for 0.46-1% of intracranial tumors. 16) Only four cases of interhemispheric lipoma connected to subcutaneous lipoma via a bone defect in the anterior fontanel 2,5,13) and midline parietal bone 1) have been reported in infants. A previous case of cerebellopontine angle lipoma extending to the extracranial space involved a defect in the petrous ridge, 7) and a lipomatous stalk was identified between an interhemispheric lipoma and subcutaneous tissue in a 9-week-old boy.…”

Section: Discussionmentioning

confidence: 99%

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Intracranial Epidermoid Tumor After Subcutaneous Lipoma Excision -Case Report-

Kato

Higa

Ujiié

et al. 2008

Neurol. Med. Chir.(Tokyo)

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A 66-year-old man presented with complaints of numbness for the past 5 years and progressive motor weakness of the right leg for the previous 2 months. Magnetic resonance imaging revealed large intraand extracranial tumors in the frontoparietal region. Physical examination suggested the extracranial lesion was a subcutaneous lipoma, which had been partially resected 60 years before, connected to the intracranial lesion via a defect of the skull. Gross total removal of the tumors was performed. Histological examination showed the intracranial lesion was epidermoid tumor, and connected to the extracranial lipoma by a lipoma bridge. The symptoms improved remarkably following surgery. This case of intracranial epidermoid tumor associated with intra-extracranial lipoma indicates that implantation of skin tissue in childhood carries the risk of epidermoid tumor even after several decades. Neuroimaging screening is recommended to detect the development of any intracranial components.

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“…Different communication patterns can be observed between intracranial and extracranial components of the lipoma. They may have no connection, 6 may connect to each other by fibrous-lipomatous stalk, 7,8 or may have direct continuity with each other through cranium bifidum. 9 There is difficulty in the explanation of extracranial extension of the intracranial lipoma via cranium bifidum.…”

Section: Discussionmentioning

confidence: 99%

Intracranial and Subcutaneous Lipoma Associated with Sagittal Sinus Fenestration and Falcine Sinus

Ahmetoğlu¹,

Kul²,

Kuzeylı³

et al. 2007

American Journal of Neuroradiology

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SUMMARY: Intracranial lipomas are rare lesions. Intracranial lipoma associated with a subcutaneous lipoma is extremely rare. Various vascular abnormalities have been described in association with intracranial lipoma, including distension, kinking, or narrowing of arteries and veins; arteriovenous malformation; and aneurysm. To our knowledge, association of sagittal sinus fenestration, falcine sinus, and absent straight sinus with intraextracranial lipoma has not been reported before. We report the imaging findings of an infant with interhemispheric and subcutaneous lipoma associated with falcine sinus and sagittal sinus fenestration.

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Interhemispheric lipoma connected to subcutaneous lipoma via lipomatous stalk

Cited by 16 publications

References 9 publications

Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse

Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse

Intracranial Epidermoid Tumor After Subcutaneous Lipoma Excision -Case Report-

Intracranial and Subcutaneous Lipoma Associated with Sagittal Sinus Fenestration and Falcine Sinus

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