Interhemispheric interaction between human dorsal premotor and contralateral primary motor cortex

Mochizuki, Hitoshi; Huang, Ying Zu; Rothwell, John C.

doi:10.1113/jphysiol.2004.072843

Cited by 194 publications

(182 citation statements)

References 28 publications

(40 reference statements)

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“…Also, they are in accordance with a number of studies which used electrophysiological approaches, particularly TMS (Ferbert et al, 1992;Mochizuki et al, 2004;Lee et al, 2007) to confirm the role of the corpus callosum in interhemispheric inhibition.…”

Section: Discussionsupporting

confidence: 61%

Estradiol Modulates Functional Brain Organization during the Menstrual Cycle: An Analysis of Interhemispheric Inhibition

Weis

Hausmann²,

Stoffers³

et al. 2008

J. Neurosci.

122

126

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According to the hypothesis of progesterone-mediated interhemispheric decoupling (Hausmann and Güntürkün, 2000), functional cerebral asymmetries (FCAs), which are stable in men and change during the menstrual cycle in women, are generated by interhemispheric inhibition of the dominant on the nondominant hemisphere. The change of lateralization during the menstrual cycle in women might indicate that sex hormones play an important role in modulating FCAs. We used functional magnetic resonance imaging to examine the role of estradiol in determining cyclic changes of interhemispheric inhibition. Women performed a word-matching task, while they were scanned twice during the cycle, once during the menstrual and once during the follicular phase. By use of a connectivity analysis we found that the inhibitory influence of left-hemispheric language areas on homotopic areas of the right hemisphere is strongest during the menses, resulting in a pronounced lateralization. During the follicular phase, due to rising estradiol levels, inhibition and thus functional cerebral asymmetries are reduced. These results reveal a powerful neuromodulatory action of estradiol on the dynamics of functional brain organization in the female brain. They may further contribute to the ongoing discussion of sex differences in brain function in that they help explain the dynamic part of functional brain organization in which the female differs from the male brain.

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Section: Discussionsupporting

confidence: 61%

Estradiol Modulates Functional Brain Organization during the Menstrual Cycle: An Analysis of Interhemispheric Inhibition

Weis

Hausmann²,

Stoffers³

et al. 2008

J. Neurosci.

122

126

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“…Previous IHI studies have generally focussed on the M1 regions, yet it is possible that other interhemispheric interactions could explain the greater activity in other cortical regions. For example it has been shown that activity in the PMd can inhibit the contralateral M1 (Mochizuki et al 2004), therefore the higher activity that was observed in the bilateral condition may offset some of the inhibition from other sites.…”

Section: Discussionmentioning

confidence: 99%

Bilateral motor tasks involve more brain regions and higher neural activation than unilateral tasks: an fMRI study

2014

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Movements that involve simultaneous coordination of muscles of the right and left lower limbs form a large part of our daily activities (e.g., standing, rising from a chair). This study used functional magnetic resonance imaging (fMRI) to determine which brain areas are used to control coordinated lower limb movements, specifically comparing regions that are activated during bilateral exertions to those performed unilaterally. Plantarflexor exertions were produced at a target force level of 15% of the participants' maximum voluntary contraction, in three conditions, with their right (dominant) foot, with their left foot and with both feet simultaneously. A voxelwise analysis determined which regions were active in the bilateral, but not in the unilateral conditions. In addition, a regions of interest (ROI) approach was used to determine differences in the percent signal change (PSC) between the conditions within motor areas. The voxel-wise analysis showed a large number of regions (cortical, subcortical and cerebellar) that were active during the bilateral condition, but not during either unilateral condition. The ROI analysis showed several motor regions with higher activation in the bilateral condition than unilateral conditions; further, the magnitude of bilateral PSC was more than the sum of the two unilateral conditions in several of these regions. We postulate that the greater levels of activation during bilateral exertions may arise from interhemispheric inhibition, as well as from the greater need for motor coordination (e.g., synchronizing the two limbs to activate together) and visual processing (e.g., monitoring of two visual stimuli).

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“…Early and strong facilitation was associated with better performance in bimanual antiphase movements, whereas delayed facilitation was found in subjects with poor anti-phase stability. In previous studies, it has been demonstrated that while resting hands, interhemispheric PMd-M1 interactions are inhibitory (Mochizuki et al, 2004;Ni et al, 2009) but may turn into strictly timed and short-lasting facilitation during the premovement period (Koch et al, 2006;O'Shea et al, 2007;Liuzzi et al, 2010). By combining TMS and fMRI, Bestmann et al (2008) showed that a TMS pulse over the PMd elicits different effects on the motor regions of the opposite hemisphere depending on the state of the motor system.…”

Section: Discussionmentioning

confidence: 99%

Coordination of Uncoupled Bimanual Movements by Strictly Timed Interhemispheric Connectivity

Liuzzi¹,

Hörniß²,

Zimerman³

et al. 2011

Journal of Neuroscience

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Independent use of both hands is characteristic of human action in daily life. By nature, however, in-phase bimanual movements, for example clapping, are easier to accomplish than anti-phase movements, for example playing the piano. It is commonly agreed that interhemispheric interactions play a central role in the coordination of bimanual movements. However, the spatial, temporal, and physiological properties of the interhemispheric signals that coordinate different modes of bimanual movements are still not completely understood. More precisely, do individual interhemispheric connectivity parameters have behavioral relevance for bimanual rapid anti-phase coordination? To address this question, we measured movement-related interhemispheric interactions, i.e., inhibition and facilitation, and correlated them with the performance during bimanual coordination. We found that movement-related facilitation from right premotor to left primary motor cortex (rPMd-lM1) predicted performance in anti-phase bimanual movements. It is of note that only fast facilitation during the preparatory period of a movement was associated with success in anti-phase movements. Modulation of right to left primary motor interaction (rM1-lM1) was not related to anti-phase but predicted bimanual in-phase and unimanual behavior. These data suggest that strictly timed modulation of interhemispheric rPMd-lM1 connectivity is essential for independent highfrequency use of both hands. The rM1-lM1 results indicate that adjustment of connectivity between homologous M1 may be important for the regulation of homologous muscle synergies.

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Interhemispheric interaction between human dorsal premotor and contralateral primary motor cortex

Cited by 194 publications

References 28 publications

Estradiol Modulates Functional Brain Organization during the Menstrual Cycle: An Analysis of Interhemispheric Inhibition

Estradiol Modulates Functional Brain Organization during the Menstrual Cycle: An Analysis of Interhemispheric Inhibition

Bilateral motor tasks involve more brain regions and higher neural activation than unilateral tasks: an fMRI study

Coordination of Uncoupled Bimanual Movements by Strictly Timed Interhemispheric Connectivity

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