Interhemispheric inhibition of corticospinal projections to forearm muscles

Ibey, Robyn J.; Bolton, David A. E.; Buick, Alison R.; Staines, Richard; Carson, Richard G.

doi:10.1016/j.clinph.2014.12.006

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Indeed, in healthy subjects, enhancing the proprioceptive input of a hand muscle by applying a low amplitude vibration was shown to reduce corticospinal excitability of the contralateral homologous muscle, suggesting transcallosal effects ( Swayne et al, 2006 ). Likewise, interhemispheric inhibition has recently been verified for forearm muscles in healthy subjects ( Ibey et al, 2015 ). Finally, changes in the cortical representation of the intact limb have also been proven in lower limb amputees ( Simoes et al, 2012 ).…”

Section: Discussionmentioning

confidence: 83%

Reduced functional connectivity within the primary motor cortex of patients with brachial plexus injury

Fraiman

Miranda

Erthal

et al. 2016

NeuroImage: Clinical

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This study aims at the effects of traumatic brachial plexus lesion with root avulsions (BPA) upon the organization of the primary motor cortex (M1). Nine right-handed patients with a right BPA in whom an intercostal to musculocutaneous (ICN-MC) nerve transfer was performed had post-operative resting state fMRI scanning. The analysis of empirical functional correlations between neighboring voxels revealed faster correlation decay as a function of distance in the M1 region corresponding to the arm in BPA patients as compared to the control group. No differences between the two groups were found in the face area. We also investigated whether such larger decay in patients could be attributed to a gray matter diminution in M1. Structural imaging analysis showed no difference in gray matter density between groups. Our findings suggest that the faster decay in neighboring functional correlations without significant gray matter diminution in BPA patients could be related to a reduced activity in intrinsic horizontal connections in M1 responsible for upper limb motor synergies.

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Section: Discussionmentioning

confidence: 83%

Reduced functional connectivity within the primary motor cortex of patients with brachial plexus injury

Fraiman

Miranda

Erthal

et al. 2016

NeuroImage: Clinical

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“…The use of precisely-timed ‘conditioning’ magnetic or electrical pulses can activate network components such as interneurons. Measures including short intracortical inhibition (SICI)/long intracortical inhibition (LICI), intracortical-facilitation (ICF), interhemispheric inhibition and facilitation, and short afferent inhibition (SAI)/long afferent inhibition (LAI) can quantify the dysfunction of interneuronal28 and callosal29 network components and sensorimotor connections,30 generating inferences about the excitatory/inhibitory balance across cortical structures and neurotransmitter (e.g. glutamatergic, GABAergic, monoaminergic) function 31.…”

Section: Introductionmentioning

confidence: 99%

Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis

McMackin

Groppa

Babiloni

et al. 2019

J Neurol Neurosurg Psychiatry

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Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including Alzheimer’s disease (AD), Lewy body dementia (LBD), Parkinson’s disease (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are associated with changes in brain networks. However, the underlying neurophysiological pathways driving pathological processes are poorly defined. The gap between what imaging can discern and underlying pathophysiology can now be addressed by advanced techniques that explore the cortical neural synchronisation, excitability and functional connectivity that underpin cognitive, motor, sensory and other functions. Transcranial magnetic stimulation can show changes in focal excitability in cortical and transcortical motor circuits, while electroencephalography and magnetoencephalography can now record cortical neural synchronisation and connectivity with good temporal and spatial resolution.Here we reflect on the most promising new approaches to measuring network disruption in AD, LBD, PD, FTD, MS, and ALS. We consider the most groundbreaking and clinically promising studies in this field. We outline the limitations of these techniques and how they can be tackled and discuss how these novel approaches can assist in clinical trials by predicting and monitoring progression of neurophysiological changes underpinning clinical symptomatology.

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Probing interhemispheric dorsal premotor-primary motor cortex interactions with threshold hunting transcranial magnetic stimulation

Calvert

McMackin

Carson

2020

Clinical Neurophysiology

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Interhemispheric inhibition of corticospinal projections to forearm muscles

Cited by 5 publications

References 35 publications

Reduced functional connectivity within the primary motor cortex of patients with brachial plexus injury

Reduced functional connectivity within the primary motor cortex of patients with brachial plexus injury

Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis

Probing interhemispheric dorsal premotor-primary motor cortex interactions with threshold hunting transcranial magnetic stimulation

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