Interhemispheric Functional Brain Connectivity in Neonates with Prenatal Alcohol Exposure: Preliminary Findings

Donald, Kirsten A.; Ipser, Jonathan; Howells, Fleur M.; Roos, Annerine; Fouche, Jean Paul; Riley, Edward P.; Koen, Nastassja; Woods, Roger P.; Biswal, Bharat B.; Zar, Heather J.; Narr, Katherine L.; Stein, Dan J.

doi:10.1111/acer.12930

Cited by 28 publications

(31 citation statements)

References 59 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a significant reduction in interhemispheric connectivity was not detected, increased connectivity between the striatal and brainstem/thalamus region to the sensorimotor network was observed [126]. [127], which has confounded its diagnosis.…”

Section: Brain Network Changes Revealed By Resting-state Fmrimentioning

confidence: 89%

“…Only one study to date has investigated the establishment of intrinsic resting brain network in neonates (2 to 4 weeks of age) [126]. Although a significant reduction in interhemispheric connectivity was not detected, increased connectivity between the striatal and brainstem/thalamus region to the sensorimotor network was observed [126].…”

Section: Brain Network Changes Revealed By Resting-state Fmrimentioning

confidence: 99%

See 1 more Smart Citation

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Nguyen

Chong

Tieng

et al. 2017

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Section: Brain Network Changes Revealed By Resting-state Fmrimentioning

confidence: 89%

Section: Brain Network Changes Revealed By Resting-state Fmrimentioning

confidence: 99%

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Nguyen

Chong

Tieng

et al. 2017

Magnetic Resonance Imaging

View full text Add to dashboard Cite

“…Therefore, prenatal drug exposure represents another significant threat to normal functional brain development and has been linked to both short- and long-term developmental behavioral and cognitive consequences (Ackerman and others 2008; Bandstra and others 2010; Smeriglio and Wilcox 1999). Neuroimaging studies of the effects of prenatal exposure on brain structure and function are often done in later childhood or adolescence (Donald and others 2016; Li and others 2013; Roussotte and others 2012). Although informative, these findings are more likely to reflect both initial drug effects and the confounding postnatal influence of adverse environments associated with maternal drug abuse.…”

Section: Alterations Of Normative Functional Connectivity Developmentmentioning

confidence: 99%

Functional Connectivity of the Infant Human Brain

et al. 2016

View full text Add to dashboard Cite

Infancy is a critical and immensely important period in human brain development. Subtle changes during this stage may be greatly amplified with the unfolding of different developmental processes, exerting far-reaching consequences. Studies of the structure and behavioral manifestations of the infant brain are fruitful. However, the specific functional brain mechanisms that enable the execution of different behaviors remained elusive until the advent of functional connectivity fMRI (fcMRI), which provides an unprecedented opportunity to probe the infant functional brain development in vivo. Since its inception, a burgeoning field of infant brain functional connectivity study has emerged and thrived during the past decade. In this review, we describe (1) findings of normal development of functional connectivity networks and their relationships to behaviors and (2) disruptions of the normative functional connectivity development due to identifiable genetic and/or environmental risk factors during the first 2 years of human life. Technical considerations of infant fcMRI are also provided. It is our hope to consolidate previous findings so that the field can move forward with a clearer picture toward the ultimate goal of fcMRI-based objective methods for early diagnosis/identification of risks and evaluation of early interventions to optimize developing functional connectivity networks in this critical developmental window.

show abstract

“…In a resting state connectivity study of adults with prenatal alcohol exposure compared to healthy controls (Santhanam et al, 2011), alcohol-exposed adults displayed reduced connectivity between the middle prefrontal cortex and posterior cingulate cortex, regions within the default mode network, relative to control participants. Moreover, recent research suggests that some of these abnormalities may appear in infancy (Donald et al, 2016). Far less research in FASD has focused on examining functional connectivity of neural networks during task performance.…”

Section: Introductionmentioning

confidence: 99%

Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure

Infante

Moore

Bischoff‐Grethe

et al. 2017

Alcohol

Self Cite

View full text Add to dashboard Cite

Individuals prenatally exposed to alcohol often have impaired spatial working memory (SWM). This study examines functional connections of frontal and parietal regions that support SWM in children with and without prenatal alcohol exposure. Children ages 10 to 16 with histories of heavy prenatal alcohol exposure (AE group; n = 18) and controls (CON group; n = 19) underwent functional magnetic resonance imaging while performing a SWM task. Whole brain task-related functional connectivity of bilateral dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC) seed regions were estimated for each participant using a psychophysiological interaction approach. Children in the AE group were less accurate than children in the CON group when performing the SWM task (p = .008). Positive coupling between bilateral DLPFC seeds and regions within the fronto-parietal network was observed in the CON group, whereas the AE group showed negative connectivity. In contrast to the CON group, the AE group showed positive connectivity between PPC seeds and frontal lobe regions. Across seeds, decreased negative coupling with regions outside the fronto-parietal network (e.g., left middle occipital gyrus) were observed in the AE group relative to the CON group. Functional data clusters were considered significant at p < .05. Overall findings suggest that localized alterations in neural activity, aberrant fronto-parietal network synchrony, and poor coordination of neural responses with regions outside of this network may help explain SWM deficits in individuals with a history of heavy prenatal alcohol exposure.

show abstract

Interhemispheric Functional Brain Connectivity in Neonates with Prenatal Alcohol Exposure: Preliminary Findings

Cited by 28 publications

References 59 publications

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Functional Connectivity of the Infant Human Brain

Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure

Contact Info

Product

Resources

About