Interhemispheric difference in susceptibility to epileptogenesis: Evidence from the audiogenic kindling model in Wistar rats

Vinogradova, Lyudmila V.

doi:10.1016/j.brainres.2010.03.037

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…Our study showed that although SWDs were not lateralized to the left or right hemisphere, myoclonic seizures exhibited a greater fraction of spikes starting in the right S1 than the left. Our finding of myoclonic seizure lateralization onset to right S1 in Gabra1 +/A322D mice is consistent with previous reports showing EEG lateralization in human JME, rodent audiogenic seizures, and rodent sensory processing …”

Section: Discussionsupporting

confidence: 93%

Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy

Ding

Gallagher

2016

Epilepsia

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Objective Generalized epilepsy syndromes often confer multiple types of seizures, but it is not known if these seizures activate separate or overlapping brain networks. Recently, we reported that mice with a juvenile myoclonic epilepsy mutation [Gabra1(A322D)] exhibited both absence and myoclonic generalized seizures. Here, we determined the time course of sensorimotor cortex activation and the spatial distribution of spike voltage during these two seizures. Methods We implanted Gabra1+/A322D mice with multiple EEG electrodes over bilateral somatosensory cortex barrel fields (S1) and anterior (aM1) and posterior (pM1) motor cortices and recorded absence seizures / spike-wave discharges (SWDs) and myoclonic seizures. We used nonlinear-association analyses and cross-correlation calculations to determine the strength, leading regions, and time delays of cortical coupling from the preictal to ictal states and within the spike and interspike periods. The distribution of spike voltage was also measured in SWDs and myoclonic seizures. Results EEG connectivity among all electrode pairs increased at the onset of both SWDs and myoclonic seizures. Surprisingly, during spikes of both seizure types, S1 led M1 with similar delay times. Myoclonic seizure spikes started more focally than SWD spikes with a significant majority appearing first only in S1 electrodes while a substantial fraction of SWD spikes were detected first in S1 and at least one M1 electrode. The absolute voltage of myoclonic seizure spikes was significantly higher than that of SWD spikes and there was a greater relative voltage over M1 during myoclonic seizure spikes than in the first one to two SWD spikes. Significance The leading sites in S1 and similar delay times suggest both SWDs and myoclonic seizures activate overlapping networks in sensorimotor cortex and thus, therapeutically targeting this network could potentially treat both seizures. Spike focality, absolute voltage and voltage distribution provide insight into neuronal activation during these two seizure types.

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Section: Discussionsupporting

confidence: 93%

Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy

Ding

Gallagher

2016

Epilepsia

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“…Aynı çalışmada, Wag/Rij sıçanlarında ise koşu davranışının yönünde hemisferik bir farklılık tespit edilememiştir. [25,26] Odyojenik nöbet oluşumunda hemisferler arasındaki bu farklılığın nedeni tam olarak bilinmemektedir. Epileptik aktivitenin sol kortekste daha kolay yayılması ya da beyin sapından kaynaklanan epileptik deşarjların sağ ve sol hemisferler içine yayılmasında farklı yolakların olması mümkün görünmektedir.…”

Section: Discussionunclassified

“…Epileptik aktivitenin sol kortekste daha kolay yayılması ya da beyin sapından kaynaklanan epileptik deşarjların sağ ve sol hemisferler içine yayılmasında farklı yolakların olması mümkün görünmektedir. [26] Bu çalışma epilepside hemisferik farklılık olduğunu tespit eden çalışmaları desteklemektedir. Sağ hemisferde tespit ettiğimiz bu nöron azlığı, sağ süperiyor kollikulusun odyojenik nöbetin başlamasında, daha önce veya daha fazla aktivasyon gösterdiğini düşündürmektedir.…”

Section: Discussionunclassified

Assesment of superior colliculus with a stereological method in audiogenic epilepsy-prone Wistar rats

Keloğlan¹

2017

Epilepsi

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Objectives: Audiogenic seizures are generated in the brainstem and involve inferior and superior colliculi in their expression. The aim of the present study was to assess total number of neurons in the right and left superior colliculi in genetically audiogenic epilepsy-prone Wistar rats using stereological method.Methods: Ten female Wistar rats, weighing 180 to 220 g each, were divided into 2 groups: control (n=5) and audiogenic epilepsy (n=5) groups. Subjects were anesthetized with urethane (1.25 g/kg; intraperitoneal) and perfused through the left cardiac ventricle with 10% formalin. Total number of neurons was estimated in the right and left superior colliculi in both groups using Optical Fractionator stereological method.Results: Total number of neurons in the superior colliculi was statistically lower in the right side of group with epilepsy compared with control group (p<0.05). There was significant difference between right and left sides in groups with epilepsy (p<0.05). Conclusion:It has been determined that cellular mechanisms have significant role in audiogenic epilepsy. The fact that number of neurons was significantly less in right superior colliculus of epilepsy group compared with control group suggests that this area is likely to be influential in triggering onset of seizure activity. ÖzetAmaç: Odyojenik nöbet beyin sapından kaynaklanır ve odyojenik nöbet ağında inferiyor ve süperiyor kollikuluslar rol alır. Sunulan çalışmada amacımız genetik olarak odyojenik epilepsiye yatkın Wistar sıçanların sağ ve sol süperiyor kollikulusda bulunan toplam nöron sayısının stereolojik metot ile bulunmasıdır. Gereç ve Yöntem:Ağırlıkları 180-220 gr olan on dişi Wistar sıçan kontrol (n=5) ve epilepsi (n=5) olmak üzere iki gruba ayrıldılar. Sıçanların hepsi üretan (1.25 g/kg; i.p) ile anesteziye alındılar ve sol kardiyak ventrikülden %10'luk formalin ile perfüze edildiler. Sağ ve sol süperiyor kollikulusda bulunan toplam nöron sayısı stereolojik optik parçalama metodu kullanılarak hesaplandı.Bulgular: Toplam nöron sayısı epilepsi sağ grubunda kontrol grubuna göre anlamlı ölçüde daha az bulundu (p<0.05). Epilepsi sağ ve epilepsi sol grupları arasında da toplam nöron sayısında anlamlı fark bulundu (p<0.05). Sonuç:Odyojenik epilepside hücresel mekanizmalar önemli rol oynamaktadır. Sağ süperiyor kollikulusda nöron sayısının kontrole göre anlamlı ölçüde az olması, nöbet aktivitesinin başlamasında bu alanın etkili olabileceğini düşündürmektedir.

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“…In focal epilepsy (e.g., temporal lobe epilepsy), a local epileptic focus is formed in one of the hemispheres of the brain, most often as a result of the formation of focal pathology (stroke, tumor) or trauma. In generalized epilepsy, an abnormal excitation spreads widely in the brain; in this case, seizures are associated with the simultaneous activation of many areas of both hemispheres [ 29 , 30 ]. In the case of a combined form of epilepsy (e.g., Dravet syndrome), both focal and generalized seizures may be recorded [ 31 ].…”

Section: Classification and Etiology Of Epilepsymentioning

confidence: 99%

Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives

et al. 2022

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Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy in animals are used, including electroconvulsive, pharmacological in intact animals, and genetic, with the predisposition for spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in current epileptology.

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Interhemispheric difference in susceptibility to epileptogenesis: Evidence from the audiogenic kindling model in Wistar rats

Cited by 6 publications

References 26 publications

Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy

Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy

Assesment of superior colliculus with a stereological method in audiogenic epilepsy-prone Wistar rats

Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives

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