Interhemispheric cortico-cortical paired associative stimulation of the prefrontal cortex jointly modulates frontal asymmetry and emotional reactivity

Zibman, Samuel; Daniel, Edan; Alyagon, Uri; Etkin, Amit; Zangen, Abraham

doi:10.1016/j.brs.2018.10.008

Cited by 30 publications

(15 citation statements)

References 57 publications

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“…Recently, in the first demonstration of ccPAS in the cognitive domain, we reported putative cortico-cortical and cortico-subcortical effects of ccPAS of the pre-supplementary motor area and inferior frontal cortex on inhibitory behaviour as a function of age (Kohl et al., 2018). This study was followed by a second report of ccPAS in the cognitive domain, which found effects on attentional bias accompanied by bidirectional changes in frontal interhemispheric connectivity depending on the order of stimulation (Zibman, Daniel, Alyagon, Etkin, & Zangen, 2019), replicating the order-dependent effects observed in motor ccPAS (Veniero, Ponzo, & Koch, 2013). Recently, an innovative ccPAS study using resting-state connectivity measures to acquire individualised parietal and prefrontal stimulation targets found bidirectional effects on spontaneous and task-evoked networks (default mode and task-positive) (Santarnecchi et al., 2018).…”

Section: Introductionmentioning

confidence: 79%

“…There are several important caveats to our claims. The novelty of this approach [with different ccPAS only having been used in the cognitive domain twice before (Kohl et al., 2018, Zibman et al., 2019)] requires replication in larger studies, as well as specific investigations of its neural basis using other techniques. In addition, any effects we report (both null and positive) require confirmation in a clinically-relevant group, as it is unclear if our results will generalise to populations with disordered decision-making.…”

Section: Discussionmentioning

confidence: 99%

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The effect of frontoparietal paired associative stimulation on decision-making and working memory

Nord

Popa

Smith

et al. 2019

Cortex

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Previous single-site neurostimulation experiments have unsuccessfully attempted to shift decision-making away from habitual control, a fast, inflexible cognitive strategy, towards goal-directed control, a flexible, though computationally expensive strategy. We employed a dual-target neurostimulation approach in 30 healthy participants, using cortico-cortical paired associative stimulation (ccPAS) to target two key nodes: lateral prefrontal cortex (LPFC) and intraparietal sulcus (IPS), to test whether decision-making can be artificially shifted from habitual toward goal-directed control. Participants received three active stimulations, delivered at least six days apart (each involving 100 paired pulses over the IPS and LPFC, varying the interstimulus interval): two interventional, time-relevant ccPAS (10 msec interval) and one control, non-time-relevant ccPAS (100 msec interval). Following stimulation, participants completed a sequential learning task, measuring goal-directed/habitual control, and a working memory task. IPS→LPFC ccPAS (stimulating IPS, then LPFC with a 10 msec interval) shifted decision-making from habitual toward goal-directed control, compared to control ccPAS. There was no effect of LPFC→IPS ccPAS, nor an effect of any PAS condition on working memory. Previous studies have shown ccPAS effects outside the motor domain targeting prefrontal regions on response inhibition, attentional bias, and alpha asymmetry. The present study measures the behavioural effects of parietal-prefrontal PAS, focusing on a highly complex decision-making task and working memory. If confirmed in larger studies, this would be the first instance of neurostimulation successfully shifting decision-making from habitual to goal-directed control, putatively via inducing long-term potentiation between the IPS and LPFC. However, we found no effect in the other direction (LPFC→IPS ccPAS), and no effect on working memory overall. PAS is a relatively new neuromodulatory technique in the cognitive arsenal, and this study could help guide future approaches in healthy and disordered decision-making.

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

The effect of frontoparietal paired associative stimulation on decision-making and working memory

Nord

Popa

Smith

et al. 2019

Cortex

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“…In the past, traditional methods of electroencephalography (EEG) analysis, including alpha power [ 12 ], amplitude [ 13 ] and coherence [ 14 ], were widely used in studies of hemispheric asymmetry during different emotional states. During emotional processing, mutual connections exist between various brain regions, which function synergistically.…”

Section: Introductionmentioning

confidence: 99%

Hemispheric Asymmetry of Functional Brain Networks under Different Emotions Using EEG Data

Cao

Shi

Wang

et al. 2020

Entropy

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Despite many studies reporting hemispheric asymmetry in the representation and processing of emotions, the essence of the asymmetry remains controversial. Brain network analysis based on electroencephalography (EEG) is a useful biological method to study brain function. Here, EEG data were recorded while participants watched different emotional videos. According to the videos’ emotional categories, the data were divided into four categories: high arousal high valence (HAHV), low arousal high valence (LAHV), low arousal low valence (LALV) and high arousal low valence (HALV). The phase lag index as a connectivity index was calculated in theta (4–7 Hz), alpha (8–13 Hz), beta (14–30 Hz) and gamma (31–45 Hz) bands. Hemispheric networks were constructed for each trial, and graph theory was applied to quantify the hemispheric networks’ topological properties. Statistical analyses showed significant topological differences in the gamma band. The left hemispheric network showed significantly higher clustering coefficient (Cp), global efficiency (Eg) and local efficiency (Eloc) and lower characteristic path length (Lp) under HAHV emotion. The right hemispheric network showed significantly higher Cp and Eloc and lower Lp under HALV emotion. The results showed that the left hemisphere was dominant for HAHV emotion, while the right hemisphere was dominant for HALV emotion. The research revealed the relationship between emotion and hemispheric asymmetry from the perspective of brain networks.

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“…Since symptom provocation activates the OCD specific circuitry, a deep and broadly stimulating H7 coil will more selectively modulate that circuit. This is an example of Hebbian plasticity (45) induced by TMS, with the specificity of the circuit induced by the provocation (46, 47).…”

Section: Introductionmentioning

confidence: 99%

A Method to Provoke Obsessive Compulsive Symptoms for Basic Research and Clinical Interventions

et al. 2019

Self Cite

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The efficacy of deep repetitive transcranial magnetic stimulation (dTMS) for obsessive compulsive disorder (OCD) was recently confirmed in a Food and Drug Administration-regulated, multicenter, sham-controlled study. In this study, patients who failed pharmacotherapy underwent individually tailored provocations just prior to each stimulation session, in the attempt to activate the relevant circuitry and making it labile to change. The procedure that was developed reliably evoked moderate intensity symptoms, making it effective on the one hand and mild enough to allow the patient to continue with the dTMS session on the other. This methodology article describes in a detailed step wise fashion how to evaluate the patient’s specific symptoms and design the individualized provocations. Additionally, the article explains how to instruct relevant personnel to administer the provocations, gauge their efficacy, and overcome possible obstacles. This method, apart from its ongoing role in the clinical treatment of OCD by dTMS, may be used for provocation of symptoms in basic studies [e.g., imaging with Electroencephalogram (EEG) or Functional magnetic resonance imaging fMRI] as well as other treatments.

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Interhemispheric cortico-cortical paired associative stimulation of the prefrontal cortex jointly modulates frontal asymmetry and emotional reactivity

Cited by 30 publications

References 57 publications

The effect of frontoparietal paired associative stimulation on decision-making and working memory

The effect of frontoparietal paired associative stimulation on decision-making and working memory

Hemispheric Asymmetry of Functional Brain Networks under Different Emotions Using EEG Data

A Method to Provoke Obsessive Compulsive Symptoms for Basic Research and Clinical Interventions

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