Interhemispheric Asymmetries of the Modular Structure in Human Temporal Cortex

Galuske, Ralf A. W.; Schlote, W.; Bratzke, H.; Singer, Wolf

doi:10.1126/science.289.5486.1946

Cited by 260 publications

(153 citation statements)

References 29 publications

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“…In general, our findings are consistent with previous neuroimaging studies showing structural (11,12,22,36,37) and maturational (38) differences of the arcuate fasciculus between left and right hemispheres. However, the existence of an arcuate fasciculus in the right human brain has never been confirmed in postmortem studies and, to the best of our knowledge, such a strong relationship between brain pathway architecture and cognitive performance has never previously been described.…”

Section: Resultssupporting

confidence: 82%

Symmetries in human brain language pathways correlate with verbal recall

Catani

Allin

Husain

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

580

520

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Lateralization of language to the left hemisphere is considered a key aspect of human brain organization. We used diffusion tensor MRI to perform in vivo virtual dissection of language pathways to assess the relationship between brain asymmetry and cognitive performance in the normal population. Our findings suggest interhemispheric differences in direct connections between Broca's and Wernicke's territories, with extreme leftward lateralization in more than half of the subjects and bilateral symmetrical distribution in only 17.5% of the subjects. Importantly, individuals with more symmetric patterns of connections are better overall at remembering words using semantic association. Moreover, preliminary analysis suggests females are more likely to have a symmetrical pattern of connections. These findings suggest that the degree of lateralization of perisylvian pathways is heterogeneous in the normal population and, paradoxically, bilateral representation, not extreme lateralization, might ultimately be advantageous for specific cognitive functions.arcuate fasciculus ͉ brain asymmetry ͉ diffusion tensor imaging ͉ language lateralization ͉ verbal memory

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Section: Resultssupporting

confidence: 82%

Symmetries in human brain language pathways correlate with verbal recall

Catani

Allin

Husain

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

580

520

View full text Add to dashboard Cite

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“…The auditory cortices at the right versus left superior temporal gyri differ anatomically and functionally, with denser and more heterogeneous subsystems in the left hemisphere both at the microcellular and macrocellular level. Pyramidal cells at the left PT are larger in size and density (Hutsler and Gazzaniga, 1996), and the left PT can contain more subsystems than the right PT within the same volume, suggesting superior fine-grained intrinsic connectivity (Galuske et al, 2000). Similarly at the macroscopic level, white-matter tracts linking temporal and frontal lobes are more widespread and greater in volume in the left hemisphere (Powell et al, 2006;Rilling et al, 2008).…”

Section: Discussionmentioning

confidence: 94%

Genome-Wide Linkage Analysis of Human Auditory Cortical Activation Suggests Distinct Loci on Chromosomes 2, 3, and 8

et al. 2012

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Neural processes are explored through macroscopic neuroimaging and microscopic molecular measures, but the two levels remain primarily detached. The identification of direct links between the levels would facilitate use of imaging signals as probes of genetic function and, vice versa, access to molecular correlates of imaging measures. Neuroimaging patterns have been mapped for a few isolated genes, chosen based on their connection with a clinical disorder. Here we propose an approach that allows an unrestricted discovery of the genetic basis of a neuroimaging phenotype in the normal human brain. The essential components are a subject population that is composed of relatives and selection of a neuroimaging phenotype that is reproducible within an individual and similar between relatives but markedly variable across a population. Our present combined magnetoencephalography and genome-wide linkage study in 212 healthy siblings demonstrates that auditory cortical activation strength is highly heritable and, specifically in the right hemisphere, regulated oligogenically with linkages to chromosomes 2q37, 3p12, and 8q24. The identified regions delimit as candidate genes TRAPPC9, operating in neuronal differentiation, and ROBO1, regulating projections of thalamocortical axons. Identification of normal genetic variation underlying neurophysiological phenotypes offers a non-invasive platform for an in-depth, concerted capitalization of molecular and neuroimaging levels in exploring neural function.

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“…8B). The existence of anatomically organized columns in higher-order auditory cortex was demonstrated recently in human brain tissue by means of postmortem tract tracing (Galuske et al, 2000). Applied to the intrinsic connections of Brodmann area 22, the technique disclosed an interconnected network of regularly spaced neuronal clusters; extending this finding to the monkey, the columns might be interconnected as depicted in the illustration (Fig.…”

Section: Auditory Cortical Columnsmentioning

confidence: 90%

Exploring the extent and function of higher-order auditory cortex in rhesus monkeys

Poremba

Mishkin

2007

Hearing Research

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Just as cortical visual processing continues far beyond the boundaries of early visual areas, so too does cortical auditory processing continue far beyond the limits of early auditory areas. In passively listening rhesus monkeys examined with metabolic mapping techniques, cortical areas reactive to auditory stimulation were found to include the entire length of the superior temporal gyrus (STG) as well as several other regions within the temporal, parietal, and frontal lobes. Comparison of these widespread activations with those from an analogous study in vision supports the notion that audition, like vision, is served by several cortical processing streams, each specialized for analyzing a different aspect of sensory input, such as stimulus quality, location, or motion. Exploration with different classes of acoustic stimuli demonstrated that most portions of STG show greater activation on the right than on the left regardless of stimulus class. However, there is a striking shift to left hemisphere "dominance" during passive listening to species-specific vocalizations, though this reverse asymmetry is observed only in the region of temporal pole. The mechanism for this left temporal pole "dominance" appears to be suppression of the right temporal pole by the left hemisphere, as demonstrated by a comparison of the results in normal monkeys with those in split-brain monkeys.

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Interhemispheric Asymmetries of the Modular Structure in Human Temporal Cortex

Cited by 260 publications

References 29 publications

Symmetries in human brain language pathways correlate with verbal recall

Symmetries in human brain language pathways correlate with verbal recall

Genome-Wide Linkage Analysis of Human Auditory Cortical Activation Suggests Distinct Loci on Chromosomes 2, 3, and 8

Exploring the extent and function of higher-order auditory cortex in rhesus monkeys

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