Interfollicular small lymphocytic lymphoma: The diagnostic significance of pseudofollicles

Ellison, Douglas J.; Nathwani, Bharat N.; Cho, Sang Y.; Martin, Sue Ellen

doi:10.1016/0046-8177(89)90231-1

Cited by 37 publications

(16 citation statements)

References 9 publications

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“…23,24 Similar to the cases in our study, the majority of interfollicular CLL/SLL cases have been reported to have low PB ALC at diagnosis. [25][26][27] However, this interfollicular/intersinus pattern is likely not helpful in predicting clinical behavior, as it has been described in both leukemic (CLL) and non-leukemic (SLL) cases and in cases with both focal and extensive LAD [25][26][27][28] and was not correlated with progression in our series. In contrast, although perifollicular proliferation centers can occur in interfollicular CLL/SLL, 25 perifollicular and follicular growth patterns are unusual in CLL/SLL and are more often seen in marginal zone and mantle cell lymphomas.…”

mentioning

confidence: 43%

Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis

Gibson

Swerdlow²,

Ferry³

et al. 2011

Haematologica

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and Hasserjian RP. Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis. Haematologica. 2011; 96:xxx doi:10.3324/haematol.2011.042333 Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has been approved by the authors. After having E-published Ahead of Print, manuscripts will then undergo technical and English editing, typesetting, proof correction and be presented for the authors ' final approval; the final version of the manuscript will then appear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process. Haematologica (pISSN: 0390-6078, eISSN: 1592-8721, NLM ID: 0417435, www.haemato-logica.org) publishes peer-reviewed papers across all areas of experimental and clinical hematology. The journal is owned by the Ferrata Storti Foundation, a non-profit organiza-tion, and serves the scientific community with strict adherence to the principles of open access publishing (www.doaj.org). In addition, the journal makes every paper published immediately available in PubMed Central (PMC), the US National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature. Official Organ of the European Hematology Association Published by the Ferrata Storti Foundation, Pavia, Italy www.haematologica.or

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mentioning

confidence: 43%

Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis

Gibson

Swerdlow²,

Ferry³

et al. 2011

Haematologica

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“…As in benign tissue, the percentage of lymphoma cell nuclei stained by MAb 12D11 was consistently lower than the percentage stained with MIB-1. In small lymphocytic lymphoma, MAb 12D11 staining was confined to the larger lymphoid cells that are present in loose aggregates (pseudofollicular proliferation centers) and are believed to represent the proliferative component of this neoplasm (25). In contrast, the predominant population of small cells, which is believed to accumulate but not divide, was nonstaining (data not shown).…”

Section: Immunostaining Of Malignant Cellsmentioning

confidence: 85%

Monoclonal Antibody Specific for Histone H1 Phosphorylated by Cyclin-Dependent Kinases: A Novel Immunohistochemical Probe of Proliferation and Neoplasia

et al. 2002

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Monoclonal antibody 12D11 (MAb 12D11) has been shown to bind histone H1 isolated from human placenta and other tissues but not histone H1 that has been digested with bacterial alkaline phosphatase. We show here that phosphorylation of phosphatase-treated histone H1 with cyclin dependent-kinase (CDK) restores binding by MAb 12D11. We conclude that MAb 12D11 selectively binds histone H1 that has been phosphorylated by CDKs, and we have investigated the use of MAb 12D11 as an immunohistochemical probe of CDK activity in situ. Previous immunofluorescence studies have revealed strong nuclear staining by MAb 12D11 in proliferating cultured cells and the absence of staining in terminally differentiated cells. Immunohistochemical staining of frozen and formalin-fixed, paraffin-embedded sections of benign tissues with MAb 12D11 was nuclear and confined to recognized foci of cell proliferation. In lymphoid germinal centers, MAb 12D11 preferentially stained large lymphoid cells with a relative lack of staining in small cleaved cells, contrasting with a lack of cell size discrimination observed with the monoclonal antibody proliferation probe, MIB-1. Tumor tissues displayed strong albeit heterogeneous staining of malignant cells by MAb 12D11, with little or no staining observed in surrounding nonneoplastic stromal cells. Differential staining by MAb 12D11 of invasive and in situ carcinoma suggest applications in prognostication. MAb 12D11 may also be useful in identification of tumors more likely to respond to therapeutic CDK inhibitors.

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“…Interfollicular small lymphocytic lymphoma (I-SLL) as described by Ellison et al 3 is an indolent malignancy of small B lymphocytes present in the interfollicular areas of lymph nodes that histologically resembles SLL. Unlike typical SLL, however, the normal lymph node architecture is not completely effaced because reactive follicles and open sinuses are also present.…”

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confidence: 99%

Histological and Immunoglobulin VH Gene Analysis of Interfollicular Small Lymphocytic Lymphoma Provides Evidence for Two Types

Bahler¹,

Aguilera

Chen³

et al. 2000

The American Journal of Pathology

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Interfollicular small lymphocytic lymphoma (I-SLL)has not been well characterized and its relationship to small lymphocytic lymphoma (SLL) or chronic lymphocytic leukemia (CLL) is uncertain. Moreover, two different proliferation center growth patterns have been described with respect to reactive germinal centers. In this study, we evaluate the histological and immunophenotypic features of 13 cases of I-SLL and immunoglobulin heavy chain variable ( Small lymphocytic lymphoma (SLL) is a B cell neoplasm that closely resembles chronic lymphocytic leukemia (CLL). It is widely recognized that SLL and CLL have the same immunophenotype (CD5ϩ, CD23ϩ, CD10Ϫ) and similar histological patterns of lymph node and marrow involvement.1,2 The only recognized difference between CLL and SLL is the predominant site of disease with CLL being primarily bone marrow-based and SLL being primarily lymph node-based.2 However, even this distinction is often arbitrary because both CLL and SLL show considerable overlap in terms of sites of involvement, especially in more advanced stages.Interfollicular small lymphocytic lymphoma (I-SLL) as described by Ellison et al 3 is an indolent malignancy of small B lymphocytes present in the interfollicular areas of lymph nodes that histologically resembles SLL. Unlike typical SLL, however, the normal lymph node architecture is not completely effaced because reactive follicles and open sinuses are also present. Similar to SLL, I-SLL have proliferation centers that in some cases are present around the reactive follicles (perifollicular) and in others localized only between reactive follicles. Proliferation centers, which have also been termed pseudofollicles, are characteristic histological features of CLL or SLL and represent pale areas composed of cells that cytologically resemble prolymphocytes and paraimmunoblasts (intermediate-sized lymphocytes with central prominent nucleoli) and more mitotic figures.4 Whether I-SLL does indeed represent SLL/CLL or some other type(s) of mature B cell neoplasm, however, has not been well established. Studies to confirm I-SLL cells have the characteristic immunophenotype of SLL have been reported for only a few cases.5 Moreover, finding perifollicular proliferation centers is a histological pattern that suggests the possibility of a marginal zone B cell neoplasm that would not be expected to express CD5 or even an atypical mantle cell lymphoma.

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Interfollicular small lymphocytic lymphoma: The diagnostic significance of pseudofollicles

Cited by 37 publications

References 9 publications

Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis

Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis

Monoclonal Antibody Specific for Histone H1 Phosphorylated by Cyclin-Dependent Kinases: A Novel Immunohistochemical Probe of Proliferation and Neoplasia

Histological and Immunoglobulin VH Gene Analysis of Interfollicular Small Lymphocytic Lymphoma Provides Evidence for Two Types

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