Interferons: between structure and function

Bandurska, Katarzyna; Król, Izabela; Myga-Nowak, Magdalena

doi:10.5604/17322693.1101229

Cited by 28 publications

(14 citation statements)

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“…It has been reported that IFN-γ in mammals can prevent the infiltration and destruction of virions in cells during virus infection, as well as the formation of virions or germination of viruses. It can further stimulate cells of the immune system to protect the human body [72]. Kidane et al reported that in vitro attenuated Histomonas meleagridis vaccination results in high levels of IFN-γ in the cecum of turkeys, which might involve important mechanisms of immune responses against avian diseases [71].…”

Section: Discussionmentioning

confidence: 99%

Bacillus amyloliquefaciens TL Downregulates the Ileal Expression of Genes Involved in Immune Responses in Broiler Chickens to Improve Growth Performance

et al. 2021

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Bacillus amyloliquefaciens TL promotes broiler chicken performance by improving nutrient absorption and utilization and reducing intestinal inflammation. In this study, RNA-sequencing (RNA-seq)-based transcriptomes of ileal tissues collected from probiotic-fed and control broiler chickens were analyzed to elucidate the effects of the probiotic B. amyloliquefaciens TL, as a feed additive, on the gut immune function. In total, 475 genes were significantly differentially expressed between the ileum of probiotic-fed and control birds. The expression of genes encoding pyruvate kinase, prothymosin-α, and heat stress proteins was high in the ileum of probiotic-fed birds (FPKM > 500), but not in the control group. The gene ontology functional enrichment and pathway enrichment analyses revealed that the uniquely expressed genes in the control group were mostly involved in immune responses, whereas those in the probiotic group were involved in fibroblast growth factor receptor signaling pathways and positive regulation of cell proliferation. Bacillus amyloliquefaciens TL downregulated the expression of certain proinflammatory factors and affected the cytokine–cytokine receptor interaction pathway. Furthermore, B. amyloliquefaciens TL in broiler diets altered the expression of genes involved in immune functions in the ileum. Thus, it might contribute to improved broiler growth by regulating the immune system and reducing intestinal damage in broilers.

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Section: Discussionmentioning

confidence: 99%

Bacillus amyloliquefaciens TL Downregulates the Ileal Expression of Genes Involved in Immune Responses in Broiler Chickens to Improve Growth Performance

et al. 2021

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“…It is divided into three types: α, β and γ. Many studies have shown that interferon (especially α-interferon and γinterferon) has an obvious anti-cell proliferation effect [46]. Therefore, low-risk patients have a better prognosis and reduce mortality through these immune response and in ammatory response.…”

Section: Discussionmentioning

confidence: 99%

Analysis of genome-wide mutation profile and establishment of risk signature for prognosis of bladder cancer

Zhao¹,

Ma²,

Liu³

et al. 2020

Preprint

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Background: Emerging studies have shown that a variety of gene mutations occur in development and progression of cancer and highly mutation genes could play oncogenic or tumor suppressive roles in cancer. Therefore, our aim is to explore mutation genes which affect the prognosis of bladder.Methods: Mutation profile was obtained and analyzed from TCGA data set. A mutation-based signature was established by multivariable Cox regression analysis. Kaplan-Meier was performed to assess the prognostic power of signature. Time-dependent ROC was conducted to evaluate predictive accuracy of signature for bladder cancer patients.Results: There are 20177 genes have alteration in 403 bladder patients and 662 of them were frequently variation (mutation frequency > 5%). In this study, we assessed the prognostic predictive ability of 662 highly mutated genes and identified a mutation signature as an independent indicator for predicting the prognosis of bladder. The time-dependent ROC showed that AUC were 0.893, 0.896, 0.916 and 0.965 at 1, 3, 5 and 10 year, respectively. Stratified analysis and Multivariate Cox analysis showed that this mutation signature was reliable and independent biomarker. Furthermore, the nomogram predictive model can be used to effectively predict clinical prognosis of bladder patients. The decision analysis curve showed patients with risk threshold of 0.03-0.92 potentially yielded clinical net benefit. Finally, we identified several signaling pathways that associated with risk score by GSEA and KEGG analysis including PI3K-Akt signaling pathway and so on.Conclusions: In general, this study provide an optimal mutation signature as potential prognosis biomarker for bladder patients.

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“…At present, two types of drug are utilized for HBV treatment, including nucleoside analogues and interferon (IFN)-α) and its derivatives ( 4 ). IFNs are cytokines that exhibit anti-proliferative, antiviral and immunomodulatory activities ( 5 , 6 ). Furthermore, IFN-α serves a key role in the inhibition of viral replication ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Anti‑HBV effect of interferon‑thymosin α1 recombinant proteins in transgenic Dunaliella�salina in�vitro and in�vivo

Zhang

Zhou

et al. 2018

Exp Ther Med

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The aim of the present study was to investigate the anti-hepatitis B virus (HBV) effect of interferon (IFN)-thymosin α1 (TA1) in a transgenic Dunaliella salina (TDS) system in vitro and in vivo. The toxicity of TDS in the HepG2.2.15 cell line was assessed using an MTT assay. The effect of TDS on the secretion of HBV early antigen (HBeAg) and HBV surface antigen (HBsAg) in culture supernatants was measured using ELISA. In addition, HBV-DNA was analyzed using quantitative polymerase chain reaction. Drug treatment experiments were performed in vivo on ducks congenitally infected with duck HBV (DHBV). The drug was administered once daily for 21 continuous days. Blood was drawn from all ducks prior to treatment, following treatment for 7, 14 and 21 days, and following drug withdrawal for 5 days. Serum DHBV-DNA was determined using quantitative PCR. In addition, the histology of duck liver tissues was assessed using hematoxylin and eosin, and orcein staining. The results demonstrated that TDS suppressed cell viability and HBsAg and HBeAg secretion in HepG2.2.15 cells. Furthermore, the treatment index values for HBsAg and HBeAg following TDS treatment were 2.96 and 3.07 respectively, which were greater than those of the IFN-α treated group. In addition, the DHBV-infected duck model experiments indicated that serum DHBV-DNA levels were significantly decreased in the group of TDS (20 g/kg) following treatment for 7, 14 and 21 days compared with the control group. Following withdrawal of the drug for 5 days, the levels of DHBV-DNA did not relapse in the medium and high dose groups of TDS (10 and 20 g/kg, respectively). Histological analysis of duck liver also demonstrated that TDS and IFN-α treatment alleviated inflammation and HBsAg signals in duck livers. In conclusion, TDS markedly suppresses HBV replication in vitro and in vivo and its anti-HBV effect is greater than that of IFN-α.

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Interferons: between structure and function

Cited by 28 publications

References 0 publications

Bacillus amyloliquefaciens TL Downregulates the Ileal Expression of Genes Involved in Immune Responses in Broiler Chickens to Improve Growth Performance

Bacillus amyloliquefaciens TL Downregulates the Ileal Expression of Genes Involved in Immune Responses in Broiler Chickens to Improve Growth Performance

Analysis of genome-wide mutation profile and establishment of risk signature for prognosis of bladder cancer

Anti‑HBV effect of interferon‑thymosin α1 recombinant proteins in transgenic Dunaliella�salina in�vitro and in�vivo

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