Interferons, a group of multiple lymphokines

“…Of these, infection-induced cytokines have the advantage of being able to alert DCs to the presence of infectious agents that do not affect DCs directly. Furthermore, those cytokines that can be expressed by a broad range of cell types in response to infection would be expected to be most effective as signals for DC activation; cytokines that may be of particular interest in this regard include type I IFN (IFN-␣␤) and IL-15 (10,11).…”

Section: Endritic Cells (Dcs)mentioning

confidence: 99%

“…IFN-␣␤ is expressed at low levels in normal or axenic mice (12), but expression is markedly increased upon infection with viruses or bacteria (13); IFN-␣␤ is also elicited by components of infectious agents such as LPS, bacterial DNA, and dsRNA (5,10,14,15). Consistent with a role in linking infection to DC activation, recent studies have shown that IFN-␣␤ can activate DCs generated in vitro from either mouse bone marrow cells (3) or human peripheral blood precursors (16 -18).…”

Section: Endritic Cells (Dcs)mentioning

confidence: 99%

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

Mattei

Schiavoni

Belardelli

et al. 2001

The Journal of Immunology

388

301

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Cytokines that are induced by infection may contribute to the initiation of immune responses through their ability to stimulate dendritic cells (DCs). In this paper, we have addressed the role of IL-15 in DC activation, investigating its expression by DCs in response to three different signals of infection and examining its ability to stimulate DCs. We report that the expression of both IL-15 and the IL-15 receptor α-chain are increased in splenic DCs from mice inoculated with dsRNA (poly(I:C)), LPS, or IFN-αβ, and in purified murine splenic DCs treated with IFN-αβ in vitro. Furthermore, IL-15 itself was able to activate DCs, as in vivo or in vitro exposure of splenic DCs to IL-15 resulted in an up-regulation of costimulatory molecules, markedly increased production of IFN-γ by DC and an enhanced ability of DCs to stimulate Ag-specific CD8+ T cell proliferation. The magnitude of all of the IL-15-induced changes in DCs was reduced in mice deficient for the IFN-αβ receptor, suggesting a role for IFN-αβ in the stimulation of DCs by IL-15. These results identify IL-15 as a stimulatory cytokine for DCs with the potential for autocrine activity and link its effects to expression of IFN-αβ.

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“…Interferon gamma which is proed by T cells is known as type 2 interferon. 3 Interferon inhibits proliferation of tumor cells, multiplication of virus and changes in host immune system which plays important role in combating viruses. 4 Ribavirin is a nucleoside analogue and has greater combating potential against DNA and RNA viruses.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Triiodothyronine (T3) and Lipid Peroxidation in Hepatitis C Patients Receiving Interferon and Ribavirin

Arsalan¹,

Hammad²,

Amin³

et al. 2017

APMC

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Background: Hepatitis is an inflammatory disorder of the liver and liver is considered as vital organ of the body. Hepatitis C virus affects 3% of the world population in which 170 million people are affected chronically and 3 to 4 million affected per year. Interferon-alpha is a cytokine, which is produced by white blood cells and T lymphocytes. Destructive thyroiditis in patients receiving interferon-α therapy is analyzed based on negative TSH receptor antibodies (TRAbs) and low thyroid radioactive iodine uptake. Methodology: Fifty-Five patients of Hepatitis C and Twenty-five age and sex-matched clinically apparently healthy individuals were eligible for inclusion in the study at Jinnah Hospital Lahore. 5.0 ml blood samples were taken and subjected to centrifuge at 3000-4000 rpm for 10-15 minutes for the separation of serum. The estimation of AST, ALT and ALP, FT3, Total Protein (TP), Total bilirubin (TB) and MDA were estimated. Results: FT3 level in HCV patients was elevated remarkably (16.63±7.14) as compared to control (4.25±0.72) and statistically significant (p-value <0.05). MDA level was also increased in HCV patients (8.58±1.19) as compared to healthy persons (1.47±0.54) and statistically significant (p-value <0.05). The level of total protein (TP) in HCV patients was decreased (4.20±0.61) as compared to healthy individuals (6.23±0.51) and also statistically significant (p-value <0.05). Conclusion: Present study concluded that HCV patients treated with interferon therapy have remarkably elevated lipid peroxidation rate which caused high level of MDA and FT3 level also elevated and play significant role in HCV patients which is causative agent for the progression of the disease.

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Interferons, a group of multiple lymphokines

Cited by 89 publications

References 139 publications

Exacerbation of Thyroid Autoimmunity by Interferon .ALPHA. Treatment in Patients with Chronic Viral Hepatitis: Our Studies and Review of the Literature.

Exacerbation of Thyroid Autoimmunity by Interferon .ALPHA. Treatment in Patients with Chronic Viral Hepatitis: Our Studies and Review of the Literature.

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

Evaluation of Triiodothyronine (T3) and Lipid Peroxidation in Hepatitis C Patients Receiving Interferon and Ribavirin

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