Interferons

Sandeep, K.; Mahajan, BharatBhushan

doi:10.4103/0378-6323.148570

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…In developed countries, arsenic is still found in the treatment of acute promyelocytic leukemia as well in traditional medicines such as Chinese herbal medicines, Indian Ayurvedic medicines and homoeopathic remedies 42,58 . As arsenic‐containing medicines are used to treat chronic disorders with variable compounded concentrations, associations may be weakly inferred but establishing causation is challenging given that there are other external factors that may contribute to sporadic manifestations such as keratinocyte carcinomas 5,6,28,62–64 …”

Section: Discussionmentioning

confidence: 99%

“…42 , 58 As arsenic‐containing medicines are used to treat chronic disorders with variable compounded concentrations, associations may be weakly inferred but establishing causation is challenging given that there are other external factors that may contribute to sporadic manifestations such as keratinocyte carcinomas. 5 , 6 , 28 , 62 , 63 , 64 …”

Section: Discussionmentioning

confidence: 99%

“…42,58 As arsenic-containing medicines are used to treat chronic disorders with variable compounded concentrations, associations may be weakly inferred but establishing causation is challenging given that there are other external factors that may contribute to sporadic manifestations such as keratinocyte carcinomas. 5,6,28,[62][63][64] There are various methods to estimate arsenic levels in various samples. Currently, the 'gold standard' is atomic absorption spectrometry due to its high specificity and sensitivity compared to other methods.…”

Section: Treatment Of Chronic Arsenic Toxicity Dermatological Present...mentioning

confidence: 99%

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Cutaneous manifestations and treatment of arsenic toxicity: A systematic review

Tang

Elakis

Scardamaglia

2023

Skin Health and Disease

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Cutaneous and systemic signs of acute and chronic arsenic poisoning may be vague. Thus, an awareness of these signs is crucial to prevent late or missed diagnoses. This is especially true in non‐endemic countries where individuals may present decades after exposure, or may still be ingesting arsenic via a non‐classical exposure. Existing literature emphasizes several well‐known cutaneous presentations of arsenic toxicity while ignoring the complete clinical spectrum, including several rare tumours of relevance to the dermatologist. This study aims to review the existing literature on dermatological presentations of arsenic toxicity and their management in adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Treatment Of Chronic Arsenic Toxicity Dermatological Present...mentioning

confidence: 99%

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Cutaneous manifestations and treatment of arsenic toxicity: A systematic review

Tang

Elakis

Scardamaglia

2023

Skin Health and Disease

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“…Table 5 describes the indications of IL interferons in dermatology. [ 63 64 65 66 67 68 69 70 71 72 73 ] IL interferon may be worked as a beneficiary in some situations such as patients for whom surgery would not suitable due to the presence of hemostasis, increased risk of infection or an inability to tolerate the rigors of surgery or some cases in which malignancy occurring in particular locations (anatomic regions tricky to operate on or where scarring might result in functional impairment). Only IFN-α-2b is “on-label” for hairy cell leukaemia, malignant melanoma, follicular lymphoma, follicular non-Hodgkin’s lymphoma, AIDS-related Kaposi’s sarcoma chronic, and hepatitis C.[ 74 ]…”

Section: R Arely U Sed Il D Rug T Herapymentioning

confidence: 99%

Intralesional agents in dermatology: Pros and cons

Sakhiya¹,

Sakhiya

Kaklotar³

et al. 2021

J Cutan Aesthet Surg

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Interferons Horizon Therapeutics

Aiman¹,

Basir²,

Islam³

2022

Basic and Clinical Aspects of Interferon Gamma

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Interferons (IFNs) are a family of multi-functional proteins, called cytokines, that are produced by immune cells such as leukocytes, natural killer (NK) cells, macrophages, fibroblasts, and epithelial cells. The minute amount of these α-helical glycoproteins, produced by mammalian cells, are firm components of the innate arm of the immune system providing rapid and broad protection against numerous types of invading pathogens. Interferons, from their discovery in the 19th century, have always held out a promise of important clinical utility first as an antiviral agent and more recently holding anti-inflammatory and regenerative effects for treating various neurological diseases such as multiple sclerosis, encephalopathies, Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), etc. IFNs elicit anti-viral and anti-inflammatory properties by inducing transcription of multiple IFN stimulated genes (ISG), a response that is partly mediated by Interferon regulatory factors (IRFs). This chapter provides a brief introduction of the interferon system as well as an in-depth assessment of the interferon signature and the various assay procedures for synthesizing non-natural interferon analogs for structural analysis, which may be helpful in designing improved products and act as a diagnostic tool for neurodegenerative disorders.

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Interferons

Cited by 3 publications

References 15 publications

Cutaneous manifestations and treatment of arsenic toxicity: A systematic review

Cutaneous manifestations and treatment of arsenic toxicity: A systematic review

Intralesional agents in dermatology: Pros and cons

Interferons Horizon Therapeutics

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