Interferon-γ and tumor necrosis factor-α promote the ability of human placenta–derived mesenchymal stromal cells to express programmed death ligand-2 and induce the differentiation of CD4+interleukin-10+ and CD8+interleukin-10+Treg subsets

Li, Heng; Wang, Weiwei; Wang, Guoyan; Hou, Yun; Xu, Fenghuang; Liu, Ranran; Wang, Feifei; Xue, Jian; Hu, Tao; Luan, Xiying

doi:10.1016/j.jcyt.2015.07.018

Cited by 31 publications

(31 citation statements)

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“…Results from a previous study in our laboratory revealed that PDL2 regulated the immunosuppression of hPMSCs on T cells (22). In this experiment, the expression of PDL2 in hPMSCs was measured at different time points after incubation with IL-27 .…”

Section: Il-27 Upregulated Pdl2 Expression In Hpmscsmentioning

confidence: 92%

“…Wang et al (21) revealed that elevated serum level of IFN-g indicated a better clinical response to MSCs transplantation in lupus patients. The results from our laboratory showed that IFN-g and TNF-a could facilitate the capacity of hPMSCs to induce the generation of CD4 + IL-10 + and CD8 + IL-10 + Treg subsets by upregulating the expression of programmed death ligand 2 (PDL2) in hPMSCs (22). It has previously been demonstrated that Treg induction can be attributed to the cell surface expression of the inhibitory molecule PDL2 (23).…”

Section: Il-27 Promotes Human Placenta-derived Mesenchymalmentioning

confidence: 94%

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IL-27 Promotes Human Placenta–Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4+IL-10+IFN-γ+ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease

Chen

et al. 2019

The Journal of Immunology

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Section: Il-27 Upregulated Pdl2 Expression In Hpmscsmentioning

confidence: 92%

Section: Il-27 Promotes Human Placenta-derived Mesenchymalmentioning

confidence: 94%

IL-27 Promotes Human Placenta–Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4+IL-10+IFN-γ+ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease

Chen

et al. 2019

The Journal of Immunology

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“…Moreover, administering granulocyte-stimulating factor has been shown to be to mobilize endogenous EPCs (Zhao et al, 2013). Importantly, EPC transplantation can improve in cerebral microvascular density, regional cortical blood flow, and functional recovery in stroke models (Chen et al, 2008; Li et al, 2015). EPCs appear to have therapeutic potential in both the acute and chronic stages of stroke pathology.…”

Section: Identifying the Optimal Cell Type For Stem Cell Transplanmentioning

confidence: 99%

“…Placenta-derived MSCs have also been shown to suppress allogenic T-cell proliferation in vitro (Jones et al, 2007). On the other hand, interferon (IFN)-γ and tumor necrosis factor (TNF)-α enhance the ability of placenta-derived MSCs to induce the differentiation of immunoactive CD4(+)IL-10(+)and CD8(+)IL-10(+)Treg subsets and express programmed cell death ligand-2, implying certain microenvironments could encourage placenta-derived MSCs to promote neuroinflammation (Li et al, 2015). Together, these results suggest that extraembryonic stem cells have significant potential to reduce ischemia-induced neuroinflammation in the brain.…”

Section: Identifying the Optimal Cell Type For Stem Cell Transplanmentioning

confidence: 99%

Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

Stonesifer

Corey

Ghanekar

et al. 2017

Progress in Neurobiology

204

207

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Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke is the upregulation of endogenous neuroinflammatory processes to levels that destroy hypoxic tissue local to the area of insult, induce apoptosis, and initiate a feedback loop of inflammatory cascades that can expand the region of damage. Stem cell therapy has emerged as an experimental treatment for stroke, and accumulating evidence supports the therapeutic efficacy of stem cells to abrogate stroke-induced inflammation. In this review, we investigate clinically relevant stem cell types, such as hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), very small embryonic-like stem cells (VSELs), neural stem cells (NSCs), extraembryonic stem cells, adipose tissue-derived stem cells, breast milk-derived stem cells, menstrual blood-derived stem cells, dental tissue-derived stem cells, induced pluripotent stem cells (iPSCs), teratocarcinoma-derived Ntera2/D1 neuron-like cells (NT2N), c-mycER(TAM) modified NSCs (CTX0E03), and notch-transfected mesenchymal stromal cells (SB623), comparing their potential efficacy to sequester stroke-induced neuroinflammation and their feasibility as translational clinical cell sources. To this end, we highlight that MSCs, with a proven track record of safety and efficacy as a transplantable cell for hematologic diseases, stand as an attractive cell type that confers superior anti-inflammatory effects in stroke both in vitro and in vivo. That stem cells can mount a robust anti-inflammatory action against stroke complements the regenerative processes of cell replacement and neurotrophic factor secretion conventionally ascribed to cell-based therapy in neurological disorders.

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“…In the absence of CD4 + T lymphocytes, naïve CD8 + T lymphocytes cannot activate into effector cells, whereas memory CD8 + T lymphocytes can proliferate and differentiate into effector cells [76].…”

Section: Differentiation Of Cd8 + T Lymphocytesmentioning

confidence: 99%

The Role of Subpopulations of Cd8+ T Lymphocytes in the Development of Pregnancy

Степанова¹,

Bazhenov²,

Khokhlova³

et al. 2018

Med. immunol.

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At the present time, a broad spectrum of CD8+ T lymphocyte subsets is revealed, including naïve cells, memory cells and regulatory subpopulations. Along with cells with high cytolytic activity, some subsets with marked regulatory activity were found there. Each subpopulation is characterized by a set of produced mediators, surface and intracellular markers allowing to suggest their differential in vivo functional activity. The present review article proposes a classification of CD8+ Т cells which takes into account their morphological and functional features. According to conventional view, the CD8+ Т lymphocytes is a cell population exhibiting high cytotoxic ability which is of critical significance in pregnancy, under the conditions of semi-allogenic fetal cell invasion into the endometrium. The fraction of CD8+ T cells is rather high in decidual structures. The review discusses the known mechanisms of differentiation regulation, selective migration and activity of CD8+ T cells in decidual membrane and placenta in the course of pregnancy. Perforine and granzyme are the main cytotoxicity factors of CD8+ Т cells. IL-2, IL-5, IL-13, IFNγ, IL-17, TGF-β and IL-10 cytokines are considered regulatory mediators of CD8+ cells. To induce the effector properties of CD8+ T cells, an antigenic stimulation is required, which is provided by interactions between the CD8+ Т cells and activated CD4+ Т cells or dendritic cells, cytokine effects. Specific differentiation of the CD8+ T cells is determined by differences in microenvironvent. In the course of pregnancy, accumulation of CD8+ Т cells is observed in decidual membrane, but their phenotype and functional properties differ from CD8+ Т cells in peripheral blood. At present time, the mechanisms of selective CD8+ T cell migration to decidual membrane are studied. These events are suggested to be mediated by means of CXCR3 and CCR5 chemokine receptors, IL-6 and IL-15 cytokines. The features of CD8+ Т cell activities, and production of some cytokines, e.g., CSF2, IFNγ, IL-1β, IL-2, IL-6, IL-8,IL-10, IL-12 and TNFα in decidual membrane and is of critical significance for effective invasion of trophoblast cells. In turn, the trophoblast and placental cells promote development of regulatory CD8+ Т lymphocytes in decidual membrane, being able to induce CD8+ T cell apoptosis in decidual membrane. Hence, interaction between the maternal CD8+ T cells and trophoblast in the area of uterine-placental contact is an important link during development of immunological tolerance in the maternal/fetal system.

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Interferon-γ and tumor necrosis factor-α promote the ability of human placenta–derived mesenchymal stromal cells to express programmed death ligand-2 and induce the differentiation of CD4+interleukin-10+ and CD8+interleukin-10+Treg subsets

Cited by 31 publications

References 38 publications

IL-27 Promotes Human Placenta–Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4+IL-10+IFN-γ+ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease

IL-27 Promotes Human Placenta–Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4+IL-10+IFN-γ+ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease

Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

The Role of Subpopulations of Cd8+ T Lymphocytes in the Development of Pregnancy

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