Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

Snapper, Clifford M.; Paul, William E.

doi:10.1126/science.3107127

Cited by 1,818 publications

(1,180 citation statements)

References 25 publications

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“…As HgCl 2 induces a Th2 response [1,8,9], it is perhaps not surprising that release of Th cells from inhibitory CD8 control might initially result in an exacerbation of Th2 responses (IgE at days 4-7), followed by an increase in Th1 responses (IFNat days 9-17), particularly as this matches the time that Th1 responses have been found to recover in this model [27]. Furthermore, the known inhibitory effect of IFN-on IgE production [28] may explain why the enhancement in IgE was not found after day 7. As HgCl 2 A is / T cell-dependent and Th2-associated, it is possible that an enhancement of regulatory Th1 functions (IFNat days 9-17) might have resulted in the protective effect on the arthritis.…”

Section: Anti-cd8 and Hgcl 2 -Induced Arthritismentioning

confidence: 86%

Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity

Kiely

O’Brien

Oliveira

1996

Clinical and Experimental Immunology

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SUMMARYMercuric chloride (HgCl 2 ) induces a T cell-dependent autoimmune syndrome in Brown-Norway (BN) rats characterized by a humoral response, tissue injury with an accumulation of CD8 and CD4 T cells, and an increase in tissue IL-4 mRNA and serum IgE suggesting Th2 cell activation. In other models of autoimmune disease, CD8 cells act in both anti-and pro-inflammatory capacities, suggesting that functionally distinct CD8 populations exist in vivo. The effect of treatment with OX8, a depleting anti-CD8 MoAb, on the initiation of HgCl 2 -induced autoimmunity was assessed in two experiments in a total of 20 BN rats, and compared with 20 animals treated with a control MoAb or PBS. OX8 significantly depleted peripheral blood CD8 lymphocytes, had no effect on HgCl 2 -induced anti-collagen or myeloperoxidase antibodies, nor on the incidence or severity of caecal vasculitis. The severity of HgCl 2 -induced arthritis was significantly reduced in OX8-treated animals; median peak score reduced from 7 . 5 to 3 . 0 (experiment 1) and from 7 . 0 to 4 (experiment 2) (P 0 . 009, Mann-Whitney U-test). OX8 treatment also exacerbated the early rise in HgCl 2 -induced IgE and induced a significant rise in plasma interferon-gamma (IFN-°), suggesting that CD8 cells may have a regulatory influence on Th cell populations. These data provide direct evidence that CD8 cells may act in a proinflammatory capacity in both this model of autoimmunity and the pathogenesis of inflammatory arthritis.

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Section: Anti-cd8 and Hgcl 2 -Induced Arthritismentioning

confidence: 86%

Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity

Kiely

O’Brien

Oliveira

1996

Clinical and Experimental Immunology

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“…In addition to the magnitude of humoral immune responses we also analyzed the isotype of anti-Aβ 42 antibodies, since this characteristic has previously been used as an indirect measure of the contribution of Th1 (IgG2a) and Th2 (IgG1) cytokines to the immune response [44][45][46]. Three to six injections with PADRE-Aβ 1-15 -MAP epitope vaccine formulated in Alum generated predominantly IgG1 anti-Aβ antibodies in BALB/c mice (Fig.…”

Section: Anti-aβ Antibody Responses In Balb/c and C57bl/6 Mice After mentioning

confidence: 99%

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch

Ghochikyan

Mkrtichyan

Petrushina

et al. 2006

Vaccine

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“…This effect may result from the preferential stimulation of suhsets of helper T lymphocytes whose lymphokines intluence isotype switching in antibody producing cells (6,7), The production of interferon-gamma (7-IFN)or IL-4 by subsets of helper T lymphocytes reciprocally regulates production of lgG2a and IgG 1/E in mice (8). although the situation is less clear in other species.…”

Section: Itidividualsmentioning

confidence: 99%

Influence of antigens and adjuvants on the production of gamma‐interferon and antibody by ovine lymphocytes

Emery

Rothel

Wood

1990

Immunology & Cell Biology

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SummaryThe production of gamma-interferon (y-IFN) and antigen-speeific immunoglobulin isotypes was monitored in sheep given primarj' and seeondary inocula of protein and polysaccharide antigens with or without adjuvants. In efferent lymph from prefemoral nodes draining the site of inoculation, y-IFN levels increased within 24 h after injection of adjuvants Quill A. dextran sultate (DXS) and 6 days after oil adjuvants in saline. The increased synthesis of y-lFN was prolonged by 1-2 days by the presence of adjuvanted antigen, but the major stimulus to y-IFN production was provided by the adjuvant. Alhydrogel (AH) did not initiate y-IFN synthesis. Following a second inocula of antigen in saline, increased levels of y-lFN were detected in efferent lymph after 3-4 h, and persisted for at least 2 days. Following cultivation ofleucocytes from immunized sheep with specific antigen in vitro, strong positive correlations between levels of interleukin (IL) IL-2, y-lFN, proliferative responses and antibody titres were observed. However, after analysisof the antigen-specitic isotypesof immunoglobulin (Ig) there was no correlation between the production of-y-lFN and particular Ig isotypes. Together with findings that AH did not preferentially induce IgGl or IgG2. these results suggest that the specific subpopulations of helper T lymphocytes which regulate the production of antibody isotypes by differential secretion of y-lFN or IL-4, are not as clearly defined in sheep as in mice.

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Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

Cited by 1,818 publications

References 25 publications

Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity

Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch

Influence of antigens and adjuvants on the production of gamma‐interferon and antibody by ovine lymphocytes

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