Interferon β-induced acute pancreatitis: About two cases with literature review

Aouinti, Imen; Hamza, Imen; Charfi, Ons; Lakhoua, Ghozlane; Aidli, Sihem El; Daghfous, Riadh; Zaiem, Ahmed; Kastalli, Sarrah

doi:10.1016/j.therap.2018.12.006

Cited by 2 publications

(2 citation statements)

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“…The pathogenesis of AP induced by an imbalanced internal environment usually results from drug mistakes. Among these drugs, there are some case reports that IFN could result in AP ( 12 ). Additionally, IFN-γ has been reported to act as a promoter in a rat model of AP ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

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Novel insight on marker genes and pathogenic peripheral neutrophil subtypes in acute pancreatitis

Zhang¹,

Wang²,

Zhang³

et al. 2022

Front. Immunol.

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Acute pancreatitis is a common critical and acute gastrointestinal disease worldwide, with an increasing percentage of morbidity. However, the gene expression pattern in peripheral blood has not been fully analyzed. In addition, the mechanism of coronavirus disease 2019 (COVID-19)-induced acute pancreatitis has not been investigated. Here, after bioinformatic analysis with machine-learning methods of the expression data of peripheral blood cells and validation in local patients, two functional gene modules in peripheral blood cells of acute pancreatitis were identified, and S100A6, S100A9, and S100A12 were validated as predictors of severe pancreatitis. Additionally, through a combination analysis of bulk sequencing and single-cell sequencing data of COVID-19 patients, a pivotal subtype of neutrophils with strong activation of the interferon-related pathway was identified as a pivotal peripheral blood cell subtype for COVID-19-induced acute pancreatitis. These results could facilitate the prognostic prediction of acute pancreatitis and research on COVID-19-induced acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

“…Some case reports have shown that IFN has a strong relationship with AP ( 12 ). Additionally, IFN-γ could promote AP in a rat model ( 13 ).…”

Section: Introductionmentioning

confidence: 99%