Interferon-α in treatment of intraepithelial neoplasia of the lower genital tract: a case report

Slotman, Ben J.; Helmerhorst, Theo J.M.; Wijermans, P. W.; Calame, J.J.

doi:10.1016/0028-2243(88)90046-9

Cited by 13 publications

(5 citation statements)

References 21 publications

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“…IFN-a can be administered systemically, intralesionally or topically, and has resulted in high response rates (biopsy-proven), with low morbidity. [74][75][76] In 1998, a high failure rate of interferon in combination with isotretinoin in HPV-related VIN III was reported. Despite clinical regression, histologic features of VIN III were still present.…”

Section: Medical Therapymentioning

confidence: 99%

Squamous Vulvar Intraepithelial Neoplasia

Preti¹,

Seters²,

Sideri³

et al. 2005

Clinical Obstetrics and Gynecology

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Section: Medical Therapymentioning

confidence: 99%

Squamous Vulvar Intraepithelial Neoplasia

Preti¹,

Seters²,

Sideri³

et al. 2005

Clinical Obstetrics and Gynecology

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“…Slotman et al utilizing subcutaneous IFN-α-2b in a patient with intraepithelial neoplasia in the vulva, vagina and uterine cervix, showed that the lesion became reduced at all sites, and the uterine cervix cases presented complete remission of the disease (Slotman BJ et al 1988).…”

Section: Lower Genital Tractmentioning

confidence: 99%

“…Studies involving IFN-γ for treating CIN cases have presented therapeutic success (Iwasaka T et al 1990) but the long-term result has been inferior to surgical treatment (Sikorski M and Zrubek H, 2003). Slotman et al utilizing subcutaneous IFN-α-2b in a patient with intraepithelial neoplasia in the vulva, vagina and uterine cervix, showed that the lesion became reduced at all sites, and the uterine cervix cases presented complete remission of the disease (Slotman BJ et al 1988).…”

Section: Lower Genital Tractmentioning

confidence: 99%

Utilization of Interferon in Gynecologic and Breast Cancer

Nomelini

Mardegan

Murta

2007

Clinical medicine. Oncology

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Abstract:The usual treatment of gynecologic cancer has been surgery, chemotherapy and radiotherapy. New therapies are being developed to improve efficacy of treatment. Interferons are inducible secretory glycoproteins that have immunomodulatory, antiviral, anti-angiogenic and anti-proliferative effects. Their potential antitumor effect has been demonstrated in many studies. Some patients obtain benefi cial effects; in other patients the treatment failure can occur. IFNs can modulate the immune response and inhibition of tumor angiogenesis. When any alteration in gene expression occurs, there is modulation of the receptors of other cytokines and enzymes that control cell function. These alterations can infl uence the differentiation, cell proliferation rate and apoptosis. The molecular mechanisms that control apoptotic cell death can be improved through cancer management using IFN in single, combination or adjuvant treatment. Malignant cells generally present defects in programmed cell death and apoptosis. Immunomodulation and angiogenesis inhibition are indirect antitumor mechanisms mediated by apoptosis. With regard to immunomodulation, IFNs can have antitumor effects through increases in cytotoxic T cells, natural killer cells and dendritic cells. Angiogenesis inhibition can result from endothelial cell apoptosis. This factor is important in inhibiting tumor genesis and forming metastases. The aim of this review is to discuss the role of Interferon in the treatment of gynecologic malignancies/breast cancer and mechanisms of action.

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“…Schon früh hat De Bersaques [4], über eine solche adjuvante lokale Behandlung mit Retinoiden berichtet. Heute wird in der Regel eine adjuvante Therapie mit Interferon bevorzugt [6,21,25], das von zahlreichen Arbeitsgruppen auch in der Primärtherapie von HPV-assoziierten Veränderungen des Genitaltraktes der Frau eingesetzt wird [5,7,8]. Die adjuvante Interferonbehandlung intraepithelialer Neoplasien des unteren Genitaltraktes ist allerdings bis heute von untergeordneter Bedeutung geblieben.…”

Section: Adjuvante Therapieunclassified

Treatment of pre-neoplasia of the vulva and vagina

Küppers

2001

Der Gynäkologe

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Interferon-α in treatment of intraepithelial neoplasia of the lower genital tract: a case report

Cited by 13 publications

References 21 publications

Squamous Vulvar Intraepithelial Neoplasia

Squamous Vulvar Intraepithelial Neoplasia

Utilization of Interferon in Gynecologic and Breast Cancer

Treatment of pre-neoplasia of the vulva and vagina

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