Interferon-tau and fertility in ruminants

Forde, Niamh; Lonergan, Patrick

doi:10.1530/rep-17-0432

Cited by 74 publications

(56 citation statements)

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“…Upregulation of the five candidate ISGs was only observed following exposure to blastocysts, suggesting that the response of the endometrium is most likely related to blastocyst-secreted IFNT and not simply a general inflammatory response. IFNT is the primary agent responsible for maternal recognition of pregnancy in cattle (reviewed by Bazer & Thatcher 2017, Forde & Lonergan 2017 involving suppression of the endometrial luteolytic mechanism to maintain progesterone production by the corpus luteum via upregulation of oxytocin receptors in the endometrial epithelia of the uterus, thereby preventing the production of luteolytic prostaglandin F2 alpha (PGF2α) pulses. In the endometrium, IFNT induces or upregulates a large number of classical ISGs and regulates expression of many other genes in a cell-specific manner that are likely important for conceptus elongation, implantation and establishment of pregnancy (Hansen et al 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy recognition in cattle is initiated around Day 15-16, both at the physiological and transcriptomic level. Prior to that time, strong evidence of embryo/ pregnancy-induced changes in the endometrial transcriptome is lacking (Forde et al 2011, Bauersachs et al 2012; in those two studies, differences in the transcriptome between pregnant and cyclic animals were not detected prior to Day 15-16, by which time the conceptus is secreting copious amounts of interferon-tau (IFNT), the pregnancy recognition signal (Forde & Lonergan 2017). Nonetheless, the first week of development is critical as evidenced by the fact that, at least in high-producing dairy cows, about 50% of embryos are no longer viable by Day 6-7 (Sartori et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Blastocyst-induced changes in the bovine endometrial transcriptome

et al. 2018

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The objectives of this study were (i) to determine whether blastocyst-induced responses in endometrial explants were detectable after 6- or 24-h co-culture ; (ii) to test if direct contact is required between embryos and the endometrial surface in order to stimulate endometrial gene expression; (iii) to establish the number of blastocysts required to elicit a detectable endometrial response; (iv) to investigate if upregulation of five interferon-stimulated genes (ISGs) in the endometrium was specific to the blastocyst stage and (v) to test if alterations in endometrial gene expression can be induced by blastocyst-conditioned medium. Exposure of endometrial explants to Day 8 blastocysts for 6 or 24 h induced the expression of ISGs (, ,, ,); expression of ,, ,, ,, ,, ,, , and was not affected. Culture of explants in the presence of more than five blastocysts was sufficient to induce the effect, with maximum expression of ISGs occurring in the presence of 20 blastocysts. This effect was exclusive to blastocyst stage embryos; oocytes, 2-cell embryos or Day 5 morulae did not alter the relative abundance of any of the transcripts examined. Direct contact between blastocysts and the endometrial surface was not required in order to alter the abundance of these transcripts and blastocyst-conditioned medium alone was sufficient to stimulate a response. Results support the notion that local embryo-maternal interaction may occur as early as Day 8 of pregnancy in cattle.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blastocyst-induced changes in the bovine endometrial transcriptome

et al. 2018

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“…Low concentrations of progesterone may reduce the growth of the embryo (Lonergan, 2011). A poorly developed embryo may fail to signal the mother within the required window for maternal recognition of pregnancy (approximately 14 to 18 d after breeding; Forde and Lonergan, 2017). Failure to signal leads to early embryonic death because the uterus does not recognize the pregnancy (Wiltbank et al, 2016).…”

Section: Steroid Concentrations During the Estrous Cyclementioning

confidence: 99%

Symposium review: Selection for fertility in the modern dairy cow—Current status and future direction for genetic selection

Lucy

2019

Journal of Dairy Science

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The establishment of pregnancy following insemination is the primary definition of fertility in most dairy systems. Highly fertile cows establish pregnancy sooner after calving and require fewer inseminations than lower-fertility cows. Pregnancy occurs through a series of individual events in sequence. In postpartum cows, for example, the uterus involutes, estrous cycles are re-established, estrus is expressed and detected, sperm are deposited in the reproductive tract and capacitate, ovulation occurs and is followed by fertilization, and the corpus luteum forms and produces sufficient progesterone to maintain pregnancy. The oviduct supports early cleavage and the uterus establishes a receptive environment for the developing pregnancy. Each individual event is theoretically heritable and these events collectively contribute to the phenotype of pregnancy after insemination. Across most dairy systems, genetic selection for fertility in cows is primarily based on reduced days from calving to pregnancy (i.e., days open). Dairy systems differ with respect to reproductive management applied to cows, which may affect the relative importance of individual components to the overall fertility of the cow. In some systems, cows are inseminated after detected estrus with minimal intervention. In these systems, days open effectively captures the summation of the individual components of fertility. More intensive systems use hormonal treatments (e.g., PGF 2α , GnRH) followed by timed artificial insemination (AI). Timed AI does not invalidate days open but the individual components that contribute to days open may be more or less important. Selection of cows for days open within populations that are managed differently may place different pressures on the individual components of fertility. Ensuring uniform performance of future cows across a variety of reproductive management systems may require a greater understanding of the underlying genetics of the individual components of fertility.

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“…al., 2006;Spencer et al, 2007;Forde and Lonergan, 2017). Therefore, we did not proceed further 307with the differential gene expression comparisons of endometrium samples.…”

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confidence: 99%

Gene expression profiling ofcorpus luteumreveals the importance of immune system during early pregnancy in domestic sheep

Pokharel

Peippo²,

Weldenegodguad

et al. 2019

Preprint

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17The majority of pregnancy loss in ruminants occurs during the preimplantation stage, which is thus 18 the most critical period determining reproductive success. While ovulation rate is the major 19 determinant of litter size in sheep, interactions among the conceptus, corpus luteum and endometrium 20 are essential for pregnancy success. To evaluate the role of reproductive tract function in sheep 21 fertility, we performed a comparative transcriptome study by sequencing total RNA (mRNA and 22 miRNA) from corpus luteum (CL) and endometrium tissues collected during the preimplantation 23 stage of pregnancy in Finnsheep, Texel and F1 crosses. A total of 21,287 genes and 599 miRNAs 24were expressed in our dataset. Ten out of the top 25 most highly expressed genes were shared across 25 tissues, indicating the complementary functions of the CL and endometrium. Moreover, highly 26 expressed autosomal genes in the endometrium and CL were associated with biological processes 27 such as progesterone formation (STAR and HSD3B1) in the CL and facilitation of maternal 28 recognition of pregnancy, trophoblast elongation and implantation (LGALS15, CST3, CST6, and 29 EEF1A1) in the endometrium. In the CL, a group of sialic acid-binding immunoglobulin (Ig)-like 30 lectins (Siglecs), solute carriers (SLC13A5, SLC15A2, SLC44A5) and chemokines (CCL5, CXCL13, 31 CXCL9) were upregulated in Finnsheep, while several multidrug resistance-associated proteins 32(MRPs) were upregulated in Texel ewes. We also identified a novel ERV gene located in a reduced 33FecL locus that is associated with sheep prolificacy and is upregulated in prolific Finnsheep. 34Moreover, we report, for the first time in any species, several genes that are active in the CL during 35 early pregnancy (including SIGLEC13, SIGLEC14, SIGLEC6, MRP4, and CA5A). Importantly, 36 functional analysis of differentially expressed genes suggested that Finnsheep have a better immune 37

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Interferon-tau and fertility in ruminants

Cited by 74 publications

References 104 publications

Blastocyst-induced changes in the bovine endometrial transcriptome

Blastocyst-induced changes in the bovine endometrial transcriptome

Symposium review: Selection for fertility in the modern dairy cow—Current status and future direction for genetic selection

Gene expression profiling ofcorpus luteumreveals the importance of immune system during early pregnancy in domestic sheep

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